Search Results - "KOVACS, C. M"

Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects by ALLARD, J. P, AGHDASSI, E, CHAU, J, TAM, C, KOVACS, C. M, SALIT, I. E, WALMSLEY, S. L

“…The HIV-infected population is known to be oxidatively stressed and deficient in antioxidant micronutrients. Since in vitro replication of HIV is increased…”
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Antiretroviral Activity, Pharmacokinetics, and Tolerability of MK-0518, a Novel Inhibitor of HIV-1 Integrase, Dosed As Monotherapy for 10 Days in Treatment-Naive HIV-1-Infected Individuals by Markowitz, Martin, Morales-Ramirez, Javier O, Nguyen, Bach-Yen, Kovacs, Colin M, Steigbigel, Roy T, Cooper, David A, Liporace, Ralph, Schwartz, Robert, Isaacs, Robin, Gilde, Lucinda R, Wenning, Larissa, Zhao, Jing, Teppler, Hedy

“…BACKGROUND:MK-0518 is a novel HIV-1 integrase strand transfer inhibitor with potent in vitro activity against HIV-1 (95% inhibitory concentration [IC95] = 33…”
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Improvement of HIV-specific immunity in HIV-infected twins treated with highly active antiretroviral therapy, interleukin 2, and syngeneic adoptively transferred cells by Tsoukas, C M, Turner, H M, Hatzakis, G E, Blake, G P, Goodhew, J E, Kilby, D L, Kovacs, C M, Luetkehoelter, J R, Routy, J P, Walmsley, S L, Bernard, N F

“…Five HIV-seropositive twins were treated with HAART and given cycles of treatment consisting of adoptive cellular therapy from their HIV-seronegative identical…”
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The sequelae of acute purulent meningitis in childhood by HUTCHISON, P A, KOVACS, M C

“…Of a series of 122 children suffering from acute purulent meningitis at the Children's Hospital, Winnipeg, in the years 1952-56, 12 (9.8%) succumbed, all…”
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Early Changes in T-Cell Activation Predict Antiretroviral Success in Salvage Therapy of HIV Infection by Shepard, Brett D, Loutfy, Mona R, Raboud, Janet, Mandy, Frank, Kovacs, Colin M, Diong, Christina, Bergeron, Michele, Govan, Victoria, Rizza, Stacey A, Angel, Jonathan B, Badley, Andrew D

“…OBJECTIVE:Because effective antiretroviral therapy (ART) reduces immune activation, we hypothesize that early changes in immune activation are associated with…”
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HIV-1-Specific Memory CD4 super(+) T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4 super(+) T Cells by Yue, F Y, Kovacs, C M, Dimayuga, R C, Parks, P, Ostrowski, MA

“…HIV-1-specific CD4 super(+) T cells are qualitatively dysfunctional in the majority of HIV-1-infected individuals and are thus unable to effectively control…”
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Why Can't the Immune System Control HIV-1? Defining HIV-1-Speciflc CD4 super(+) T Cell Immunity in Order to Develop Strategies to Enhance Viral Immunity by Ostrowski, MA, Yu, Q, Yue, F Y, Liu, J, Jones, B, Gu, X X, Loutfy, M, Kovacs, C M, Halpenny, R

“…Globally, at least 60 million people have been infected with the human immunodeficiency virus type 1 (HIV-1), the majority of whom will develop the acquired…”
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HIV-1-Specific Memory CD4+ T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4+ T Cells by Yue, Feng Yun, Kovacs, Colin M, Dimayuga, Rowena C, Parks, Paul, Ostrowski, Mario A

“…HIV-1-specific CD4(+) T cells are qualitatively dysfunctional in the majority of HIV-1-infected individuals and are thus unable to effectively control viral…”
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Preferential Apoptosis of HIV-1-Specific CD4+ T Cells by Yue, Feng Yun, Kovacs, Colin M, Dimayuga, Rowena C, Gu, Xiao Xiao Jenny, Parks, Paul, Kaul, Rupert, Ostrowski, Mario A

“…In contrast to other viral infections such as CMV, circulating frequencies of HIV-1-specific CD4+ T cells in peripheral blood are quantitatively diminished in…”
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OX40 Ligation of CD4+ T Cells Enhances Virus-Specific CD8+ T Cell Memory Responses Independently of IL-2 and CD4+ T Regulatory Cell Inhibition by Yu, Qigui, Yue, Feng Yun, Gu, Xiao X, Schwartz, Herbert, Kovacs, Colin M, Ostrowski, Mario A

“…We have previously shown that CD4(+) T cells are required to optimally expand viral-specific memory CD8(+) CTL responses using a human dendritic cell-T…”
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Enhancement of HIV-Specific CD8 T Cell Responses by Dual Costimulation with CD80 and CD137L by Bukczynski, Jacob, Wen, Tao, Wang, Chao, Christie, Natasha, Routy, Jean-Pierre, Boulassel, Mohamed-Rachid, Kovacs, Colin M, MacDonald, Kelly S, Ostrowski, Mario, Sekaly, Rafick-Pierre, Bernard, Nicole F, Watts, Tania H

“…HIV-specific CD8 T cell responses are defective in chronic HIV infection. In this study, we report that costimulation with either CD137L (4-1BBL) or CD80…”
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