Search Results - "KOUNDRIOUKOFF, Stéphane"

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells by Técher, Hervé, Koundrioukoff, Stéphane, Nicolas, Alain, Debatisse, Michelle

“…Key Points The progression of replication forks is impaired when they encounter intrinsically hard-to-replicate sequences (such as repeats and secondary…”
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Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide by Brison, Olivier, El-Hilali, Sami, Azar, Dana, Koundrioukoff, Stéphane, Schmidt, Mélanie, Nähse, Viola, Jaszczyszyn, Yan, Lachages, Anne-Marie, Dutrillaux, Bernard, Thermes, Claude, Debatisse, Michelle, Chen, Chun-Long

“…Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most…”
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Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site by Letessier, Anne, Millot, Gaël A., Koundrioukoff, Stéphane, Lachagès, Anne-Marie, Vogt, Nicolas, Hansen, R. Scott, Malfoy, Bernard, Brison, Olivier, Debatisse, Michelle

“…The origins of fragility Some chromosomal locations, known as common fragile sites, are predisposed to breakage. These sites have pathological relevance…”
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Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity by Koundrioukoff, Stéphane, Carignon, Sandra, Técher, Hervé, Letessier, Anne, Brison, Olivier, Debatisse, Michelle

“…Breaks at common fragile sites (CFS) are a recognized source of genome instability in pre-neoplastic lesions, but how such checkpoint-proficient cells escape…”
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Replication Dynamics: Biases and Robustness of DNA Fiber Analysis by Técher, Hervé, Koundrioukoff, Stéphane, Azar, Dana, Wilhelm, Therese, Carignon, Sandra, Brison, Olivier, Debatisse, Michelle, Le Tallec, Benoît

“…The factors that govern replication programs are still poorly identified in metazoans, especially in mammalian cells. Thanks to molecular combing, the dynamics…”
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Updating the mechanisms of common fragile site instability: how to reconcile the different views? by Le Tallec, Benoît, Koundrioukoff, Stéphane, Wilhelm, Therese, Letessier, Anne, Brison, Olivier, Debatisse, Michelle

“…Common fragile sites (CFSs) are large chromosomal regions long identified by conventional cytogenetics as sequences prone to breakage in cells subjected to…”
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Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner by Kim, Su-Jung, Maric, Chrystelle, Briu, Lina-Marie, Fauchereau, Fabien, Baldacci, Giuseppe, Debatisse, Michelle, Koundrioukoff, Stéphane, Cadoret, Jean-Charles

“…Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have…”
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Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage by Técher, Hervé, Koundrioukoff, Stéphane, Carignon, Sandra, Wilhelm, Therese, Millot, Gaël A., Lopez, Bernard S., Brison, Olivier, Debatisse, Michelle

“…Mammalian cells deficient in ATR or Chk1 display moderate replication fork slowing and increased initiation density, but the underlying mechanisms have…”
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The RBBP6/ZBTB38/MCM10 Axis Regulates DNA Replication and Common Fragile Site Stability by Miotto, Benoit, Chibi, Moredreck, Xie, Ping, Koundrioukoff, Stéphane, Moolman-Smook, Hanlie, Pugh, David, Debatisse, Michelle, He, Fuchu, Zhang, Lingqiang, Defossez, Pierre-Antoine

“…Faithful DNA replication is essential for the maintenance of genome integrity. Incomplete genome replication leads to DNA breaks and chromosomal…”
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Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation by HENNEKE, Ghislaine, KOUNDRIOUKOFF, Stéphane, HÜBSCHER, Ulrich

“…Cyclin-dependent kinase (Cdk) Cdk1-Cyclin A can phosphorylate Flap endonuclease 1 (Fen1), a key-enzyme of the DNA replication machinery, in late S phase…”
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Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2 by Mendez-Bermudez, Aaron, Lototska, Liudmyla, Bauwens, Serge, Giraud-Panis, Marie-Josèphe, Croce, Olivier, Jamet, Karine, Irizar, Agurtzane, Mowinckel, Macarena, Koundrioukoff, Stephane, Nottet, Nicolas, Almouzni, Genevieve, Teulade-Fichou, Mare-Paule, Schertzer, Michael, Perderiset, Mylène, Londoño-Vallejo, Arturo, Debatisse, Michelle, Gilson, Eric, Ye, Jing

“…Hard-to-replicate regions of chromosomes (e.g., pericentromeres, centromeres, and telomeres) impede replication fork progression, eventually leading, in the…”
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A Direct Interaction between Proliferating Cell Nuclear Antigen (PCNA) and Cdk2 Targets PCNA-interacting Proteins for Phosphorylation by Koundrioukoff, Stéphane, Jónsson, Zophonı́as O., Hasan, Sameez, de Jong, Rob N., van der Vliet, Peter C., Hottiger, Michael O., Hübscher, Ulrich

“…Proliferating cell nuclear antigen is best known as a DNA polymerase accessory protein but has more recently also been shown to have different functions in…”
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Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation by Brison, Olivier, Gnan, Stefano, Azar, Dana, Koundrioukoff, Stéphane, Melendez-Garcia, Rodrigo, Kim, Su-Jung, Schmidt, Mélanie, El-Hilali, Sami, Jaszczyszyn, Yan, Lachages, Anne-Marie, Thermes, Claude, Chen, Chun-Long, Debatisse, Michelle

“…Genome integrity requires replication to be completed before chromosome segregation. The DNA-replication checkpoint (DRC) contributes to this coordination by…”
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Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease by Domínguez-Kelly, Raquel, Martín, Yusé, Koundrioukoff, Stephane, Tanenbaum, Marvin E, Smits, Veronique A J, Medema, René H, Debatisse, Michelle, Freire, Raimundo

“…Correct replication of the genome and protection of its integrity are essential for cell survival. In a high-throughput screen studying H2AX phosphorylation,…”
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In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis by Matos-Rodrigues, Gabriel, Barroca, Vilma, Muhammad, Ali-Akbar, Dardillac, Elodie, Allouch, Awatef, Koundrioukoff, Stephane, Lewandowski, Daniel, Despras, Emmanuelle, Guirouilh-Barbat, Josée, Frappart, Lucien, Kannouche, Patricia, Dupaigne, Pauline, Le Cam, Eric, Perfettini, Jean-Luc, Romeo, Paul-Henri, Debatisse, Michelle, Jasin, Maria, Livera, Gabriel, Martini, Emmanuelle, Lopez, Bernard S

“…Homologous recombination (HR) is a prominent DNA repair pathway maintaining genome integrity. Mutations in many HR genes lead to cancer predisposition…”
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The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin by Bauwens, Serge, Lototska, Liudmyla, Koundrioukoff, Stephane, Debatisse, Michelle, Ye, Jing, Gilson, Eric, Mendez-Bermudez, Aaron

“…Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA…”
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A post-irradiation-induced replication stress promotes RET proto-oncogene breakage by Hecht, Fabio, Valerio, Laura, Gonçalves, Carlos Frederico Lima, Harinquet, Marylin, Ameziane El Hassani, Rabii, Carvalho, Denise P, Koundrioukoff, Stephane, Cadoret, Jean-Charles, Dupuy, Corinne

“…Ionizing radiation generates genomic instability by promoting the accumulation of chromosomal rearrangements. The oncogenic translocation RET/PTC1 is present…”
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USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication by Hernández-Pérez, Santiago, Cabrera, Elisa, Amoedo, Hugo, Rodríguez-Acebes, Sara, Koundrioukoff, Stephane, Debatisse, Michelle, Méndez, Juan, Freire, Raimundo

“…DNA replication control is a key process in maintaining genomic integrity. Monitoring DNA replication initiation is particularly important as it needs to be…”
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TIPIN depletion leads to apoptosis in breast cancer cells by Baldeyron, Céline, Brisson, Amélie, Tesson, Bruno, Némati, Fariba, Koundrioukoff, Stéphane, Saliba, Elie, De Koning, Leanne, Martel, Elise, Ye, Mengliang, Rigaill, Guillem, Meseure, Didier, Nicolas, André, Gentien, David, Decaudin, Didier, Debatisse, Michelle, Depil, Stéphane, Cruzalegui, Francisco, Pierré, Alain, Roman-Roman, Sergio, Tucker, Gordon C., Dubois, Thierry

“…Triple-negative breast cancer (TNBC) is the breast cancer subgroup with the most aggressive clinical behavior. Alternatives to conventional chemotherapy are…”
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The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen by Gérard, Annabelle, Koundrioukoff, Stéphane, Ramillon, Vincent, Sergère, Jean-Christophe, Mailand, Niels, Quivy, Jean-Pierre, Almouzni, Geneviève

“…The coordination of chromatin assembly with DNA replication, which is essential for genomic stability, requires the combined activation of histone deposition…”
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