Search Results - "KOUKOURAKIS, Michael"

Tumor draining lymph nodes, immune response, and radiotherapy: Towards a revisal of therapeutic principles by Koukourakis, Michael I., Giatromanolaki, Alexandra

“…The tumor-draining lymph nodes (TDLNs) are the primary sites of the development of anti-tumor immunity. Primary tumor irradiation promotes ‘radio-vaccination’…”
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Ectonucleotidase CD73 and CD39 expression in non-small cell lung cancer relates to hypoxia and immunosuppressive pathways by Giatromanolaki, Alexandra, Kouroupi, Maria, Pouliliou, Stamatia, Mitrakas, Achilleas, Hasan, Fatma, Pappa, Aglaia, Koukourakis, Michael I.

“…Adenosine triphosphate (ATP) is released at a high concentration in the tumor microenvironment. The overexpression of ectonucleotidases in non-small-cell lung…”
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Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines by Koukourakis, Michael I, Kalamida, Dimitra, Giatromanolaki, Alexandra, Zois, Christos E, Sivridis, Efthimios, Pouliliou, Stamatia, Mitrakas, Achilleas, Gatter, Kevin C, Harris, Adrian L

“…LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have a…”
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Warburg effect, lactate dehydrogenase, and radio/chemo-therapy efficacy by Koukourakis, Michael I., Giatromanolaki, Alexandra

“…The anaerobic metabolism of glucose by cancer cells, even under well-oxygenated conditions, has been documented by Otto Warburg as early as 1927…”
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Lymphopenia and intratumoral lymphocytic balance in the era of cancer immuno-radiotherapy by Koukourakis, Michael I., Giatromanolaki, Alexandra

“…The immune response has been recognized as a major tumor-eradication component of radiotherapy. This review studies, under a clinical perspective, two…”
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Increased glucose influx and glycogenesis in lung cancer cells surviving after irradiation by Tsolou, Avgi, Koparanis, Dimitrios, Lamprou, Ioannis, Giatromanolaki, Alexandra, Koukourakis, Michael I.

“…Lung cancer is considered as one of the most frequent malignancies worldwide. Radiotherapy is the main treatment modality applied for locally advanced disease,…”
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Apalutamide radio-sensitisation of prostate cancer by Kakouratos, Christos, Kalamida, Dimitra, Lamprou, Ioannis, Xanthopoulou, Erasmia, Nanos, Christos, Giatromanolaki, Alexandra, Koukourakis, Michael I.

“…Introduction The combination of radiotherapy with bicalutamide is the standard treatment of prostate cancer patients with high-risk or locally advanced…”
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Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer by Giatromanolaki, Alexandra, Chatzipantelis, Paschalis, Contrafouris, Constantinos A., Koukourakis, Michael I.

“…We assessed the presence of 'tertiary lymphoid structures' (TLS) in a series of surgically treated non-small cell lung carcinomas (NSCLC). The TLS-density in…”
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A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer by Giatromanolaki, Alexandra, Kouroupi, Maria, Balaska, Konstantina, Koukourakis, Michael I

“…The role of senescence in defining tumor aggressiveness at a clinical level remains obscure. A novel mixed histochemical/immunohistochemical method…”
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Therapeutic interactions of autophagy with radiation and temozolomide in glioblastoma: evidence and issues to resolve by Koukourakis, Michael I, Mitrakas, Achilleas G, Giatromanolaki, Alexandra

“…Glioblastoma is a unique model of non-metastasising disease that kills the vast majority of patients through local growth, despite surgery and local…”
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Carbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+T-cell tumour stroma infiltration by Giatromanolaki, Alexandra, Harris, Adrian L., Banham, Alison H., Contrafouris, Constantinos A., Koukourakis, Michael I.

“…Background Low pH suppresses the proliferation and cytotoxic activity of CD8+ cytotoxic and natural killer lymphocytes. The hypoxia-regulated transmembrane…”
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Lipophagy-Related Protein Perilipin-3 and Resistance of Prostate Cancer to Radiation Therapy by Lamprou, Ioannis, Kakouratos, Christos, Tsolou, Avgi, Pavlidis, Pavlos, Xanthopoulou, Erasmia T., Nanos, Christos, Tsaroucha, Alexandra, Sivridis, Efthimios, Giatromanolaki, Alexandra, Koukourakis, Michael I.

“…Radiation therapy is a principal treatment modality for localized and locally advanced prostate cancer (PCa). Metabolic alterations, including lipid…”
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HLA-class-I expression loss, tumor microenvironment and breast cancer prognosis by Giatromanolaki, Alexandra, Michos, Georgios D., Xanthopoulou, Erasmia, Koukourakis, Michael I.

“…•Extensive loss HLA-class-I expression occurs 76.6% of breast carcinomas.•HLA-preservation is associated with high TIL-density and low HIF1α…”
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Immunohistochemical detection of senescence markers in human sarcomas by Giatromanolaki, Alexandra, Kouroupi, Maria, Balaska, Konstantina, Koukourakis, Michael I.

“…Senescent cells in tumors are not inert cells but exert bystander effects by developing secretory phenotypes affecting the extracellular matrix and interfering…”
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Regulatory tumor-infiltrating lymphocytes prevail in endometrial tumors with low vascular survival ability by Giatromanolaki, Alexandra, Kouroupi, Maria, Kontomanolis, Emmanuel N., Koukourakis, Michael I.

“…•Angiogenesis and vascular survival ability (VSA) vary in endomentrial caner (EC)•High tumor infiltrating lymphocyte (TIL) density is noted in tumors with low…”
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Combining the past and present to advance immuno-radiotherapy of cancer by Koukourakis, Ioannis M., Koukourakis, Michael I.

“…Since its first clinical application, 120 years ago, radiotherapy evolved into a major anti-cancer treatment modality, offering high cure rates in many human…”
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Loss of HLA-class-I expression in non-small-cell lung cancer: Association with prognosis and anaerobic metabolism by Koukourakis, Ioannis M., Giatromanolaki, Alexandra, Mitrakas, Achilleas, Koukourakis, Michael I.

“…•Extensive loss of HLA-class-I expression is noted in 64.8% of NSCLCs.•Loss of HLA-class-I is linked with poor CD8 + lymphocytic infiltration of…”
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Fever-range hyperthermia vs. hypothermia effect on cancer cell viability, proliferation and HSP90 expression by Kalamida, Dimitra, Karagounis, Ilias V, Mitrakas, Achilleas, Kalamida, Sofia, Giatromanolaki, Alexandra, Koukourakis, Michael I

“…The current study examines the effect of fever-range hyperthermia and mild hypothermia on human cancer cells focusing on cell viability, proliferation and…”
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Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research by Tsoutsou, Pelagia G, Koukourakis, Michael I

“…Radiation pneumonitis and subsequent radiation pulmonary fibrosis are the two main dose-limiting factors when irradiating the thorax that can have severe…”
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LC3A, LC3B and Beclin-1 Expression in Gastric Cancer by Giatromanolaki, Alexandra, Koukourakis, Michael I, Georgiou, Ioannis, Kouroupi, Maria, Sivridis, Efthimios

“…The current study examined the key proteins involved in autophagosome formation and their prognostic role in gastric cancer. Paraffin-embedded tissues from 121…”
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