Search Results - "KOUCHI, Mami"

Involvement of the CYP1A1 inhibition-mediated activation of aryl hydrocarbon receptor in drug-induced hepatotoxicity by Yoda, Tomomi, Tochitani, Tomoaki, Usui, Toru, Kouchi, Mami, Inada, Hiroshi, Hosaka, Takuomi, Kanno, Yuichiro, Miyawaki, Izuru, Yoshinari, Kouichi

“…Hepatotoxicity is one of the most common toxicities observed in non-clinical safety studies of drug candidates, and it is important to understand the…”
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Spontaneous membranoproliferative glomerulonephritis in a young Crl:CD-1(ICR) mouse by Tochitani, Tomoaki, Kouchi, Mami, Fuji, Yuta, Yoshino, Yuka, Matsumoto, Izumi

“…Here, we reported a spontaneous case of membranoproliferative glomerulonephritis observed in a young ICR mouse. A 5-week-old female mouse was euthanized owing…”
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Dose- and time-dependent changes in blood and adrenal levels of multiple steroids in rats after administration of ketoconazole with or without ACTH by Tochitani, Tomoaki, Yamashita, Akihito, Matsumoto, Izumi, Kouchi, Mami, Fujii, Yuta, Miyawaki, Izuru

“…To verify simultaneous measurement of blood levels of adrenal steroids as a tool to evaluate drug effects on adrenal steroidogenesis, dose- and time-dependent…”
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Physiological and drug-induced changes in blood levels of adrenal steroids and their precursors in cynomolgus monkeys: An application of steroid profiling by LC–MS/MS for evaluation of the adrenal toxicity by Tochitani, Tomoaki, Yamashita, Akihito, Matsumoto, Izumi, Kouchi, Mami, Fujii, Yuta, Yamada, Toru, Miyawaki, Izuru

“…The adrenal gland is the most common toxicological target of drugs within the endocrine system, and inhibition of adrenal steroidogenesis can be fatal in…”
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Usefulness of Simultaneous Measurement of Plasma Steroids, Including Precursors, for the Evaluation of Drug Effects on Adrenal Steroidogenesis in Rats by Tochitani, Tomoaki, Yamashita, Akihito, Matsumoto, Izumi, Kouchi, Mami, Fujii, Yuta, Miyawaki, Izuru, Yamada, Toru, Bando, Kiyoko

“…The aim of this study was to evaluate the usefulness of simultaneous measurement of plasma steroids, including precursors, for the evaluation of drug effects…”
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Changes in plasma concentrations of corticosterone and its precursors after ketoconazole administration in rats: An application of simultaneous measurement of multiple steroids using LC–MS/MS by Tochitani, Tomoaki, Yamashita, Akihito, Kouchi, Mami, Fujii, Yuta, Matsumoto, Izumi, Miyawaki, Izuru, Yamada, Toru, Funabashi, Hitoshi

“…The adrenal gland is the most common toxicological target in the endocrine system, and inhibition of adrenal steroidogenesis by drugs can be fatal in humans…”
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Dose- and time-dependent changes in blood and adrenal levels of multiple steroids in rats after administration of ketoconazole with or without ACTH by Tochitani, Tomoaki, Yamashita, Akihito, Matsumoto, Izumi, Kouchi, Mami, Fujii, Yuta, Miyawaki, Izuru

“…To verify simultaneous measurement of blood levels of adrenal steroids as a tool to evaluate drug effects on adrenal steroidogenesis, dose- and time-dependent…”
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Histopathological characteristics of renal changes in human renin-angiotensinogen double transgenic rats by Tochitani, Tomoaki, Mori, Masaya, Matsuda, Koichi, Kouchi, Mami, Fujii, Yuta, Matsumoto, Izumi

“…Abstract: The human renin-angiotensinogen double transgenic rat (dTGR) is a model of hypertension. The aim of this short report was to describe the…”
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Physiological and drug-induced changes in blood levels of adrenal steroids and their precursors in cynomolgus monkeys: An application of steroid profiling by LC–MS/MS for evaluation of the adrenal toxicity by Tochitani, Tomoaki, Yamashita, Akihito, Matsumoto, Izumi, Kouchi, Mami, Fujii, Yuta, Yamada, Toru, Miyawaki, Izuru

“…The adrenal gland is the most common toxicological target of drugs within the endocrine system, and inhibition of adrenal steroidogenesis can be fatal in…”
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Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway by Piao, Xianghua, Kobayashi, Toshiyuki, Wang, Lu, Shiono, Masatoshi, Takagi, Yumiko, Sun, Guodong, Abe, Masaaki, Hagiwara, Yoshiaki, Zhang, Danqing, Okimoto, Kazuo, Kouchi, Mami, Matsumoto, Izumi, Hino, Okio

“…The Birt–Hogg–Dubé gene (BHD) encodes the tumor suppressor protein folliculin (FLCN). The function of FLCN has recently been implicated in the regulation of…”
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Histopathological characteristics of renal changes in humanrenin-angiotensinogen double transgenic rats by Tochitani, Tomoaki, Mori, Masaya, Matsuda, Koichi, Kouchi, Mami, Fujii, Yuta, Matsumoto, Izumi

“…The human renin-angiotensinogen double transgenic rat (dTGR) is a model of hypertension. The aim of this short report was to describe the histopathological…”
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Serine 62 is a phosphorylation site in folliculin, the Birt–Hogg–Dubé gene product by Wang, Lu, Kobayashi, Toshiyuki, Piao, Xianghua, Shiono, Masatoshi, Takagi, Yumiko, Mineki, Reiko, Taka, Hikari, Zhang, Danqing, Abe, Masaaki, Sun, Guodong, Hagiwara, Yoshiaki, Okimoto, Kazuo, Matsumoto, Izumi, Kouchi, Mami, Hino, Okio

“…Recently, it was reported that the product of Birt–Hogg–Dubé syndrome gene (folliculin, FLCN) is directly phosphorylated by 5′-AMP-activated protein kinase…”
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Spontaneous Rhabdomyosarcoma in a Common Marmoset (Callithrix jacchus) by TOCHITANI, Tomoaki, MATSUMOTO, Izumi, HOSHINO, Kohei, TOYOSAWA, Kaoru, KOUCHI, Mami, KOUJITANI, Takatoshi, KIMURA, Juki, FUNABASHI, Hitoshi

“…The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background…”
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The First Case of Feline Infectious Peritonitis-like Pyogranuloma in a Ferret Infected by Coronavirus in Japan by Michimae, Yoshiko, Mikami, Shin-ichi, Okimoto, Kazuo, Toyosawa, Kaoru, Matsumoto, Izumi, Kouchi, Mami, Koujitani, Takatoshi, Inoue, Tadashi, Seki, Takaki

“…A male ferret, which was purchased from abroad at 9 months of age, had shown significant weight loss starting at 13 months of age. The ferret subsequently…”
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A Novel Renal Carcinoma Predisposing Gene of the Nihon Rat Maps on Chromosome 10 by Hino, Okio, Okimoto, Kazuo, Kouchi, Mami, Sakurai, Junko

“…A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Spra‐gue‐Dawley (SD) strain in Japan, and named the “Nihon” rat in…”
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Cystic Cholangioma in the Thoracic Cavity of a Rat by Michimae, Yoshiko, Okimoto, Kazuo, Toyosawa, Kaoru, Matsumoto, Izumi, Kouchi, Mami, Tochitani, Tomoaki, Koujitani, Takatoshi, Funabashi, Hitoshi, Seki, Takaki

“…A female congenic rat produced by repeated backcrossing of Nihon rats, a model for hereditary renal cell carcinoma, to Brown Norway rats was necropsied at 24…”
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Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dubé syndrome by KOUCHI, Mami, OKIMOTO, Kazuo, MATSUMOTO, Izumi, TANAKA, Kohji, YASUBA, Masashi, HINO, Okio

“…In the Nihon rat, an established model of hereditary renal cell carcinoma (RCC), the propensity for tumor development, is inherited as an autosomal dominant…”
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Immunohistochemical and Ultrastructural Analyses of Cytoplasmic Blood Plasma Inclusions of Rat Hepatocytes by Tochitani, Tomoaki, Toyosawa, Kaoru, Matsumoto, Izumi, Kouchi, Mami, Michimae, Yoshiko, Koujitani, Takatoshi, Funabashi, Hitoshi, Seki, Takaki

“…In the present study, we investigated the histological, immunohistochemical and ultrastructural characteristics of cytoplasmic blood plasma inclusions that…”
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Ocular lesions in Watanabe heritable hyperlipidemic rabbits by Kouchi, Mami, Ueda, Yoshinaka, Horie, Hiroshi, Tanaka, Kohji

“…Hyperlipidemic ocular lesions are described for Watanabe heritable hyperlipidemic (WHHL) rabbits. Male WHHL rabbits 8 months old exhibited serum hyperlipidemia…”
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Establishment and characterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat by Matsumoto, Izumi, Kouchi, Mami, Okimoto, Kazuo, Kijima, Kazuyasu, Ueda, Tadayoshi, Hirayama, Youko, Inoue, Tadashi, Seki, Takaki, Hino, Okio

“…A germline insertion of a single nucleotide in the rat homologue of the human Birt-Hogg-Dubé (BHD) gene gives rise to dominantly inherited renal cell carcinoma…”
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