Search Results - "KOTSCH, Katja"

Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients by Sattler, Arne, Schrezenmeier, Eva, Weber, Ulrike A, Potekhin, Alexander, Bachmann, Friederike, Straub-Hohenbleicher, Henriette, Budde, Klemens, Storz, Elena, Pross, Vanessa, Bergmann, Yasmin, Thole, Linda M.L, Tizian, Caroline, Holsken, Oliver, Diefenbach, Andreas, Schrezenmeier, Hubert, Jahrsdorfer, Bernd, Zemojtel, Tomasz, Jechow, Katharina, Conrad, Christian, Lukassen, Soren, Stauch, Diana, Lachmann, Nils, Choi, Mira, Halleck, Fabian, Kotsch, Katja

“…Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2, with BNT162b2 (trade name: Comirnaty)…”
Get full text

Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells by Pascual-Reguant, Anna, Köhler, Ralf, Mothes, Ronja, Bauherr, Sandy, Hernández, Daniela C., Uecker, Ralf, Holzwarth, Karolin, Kotsch, Katja, Seidl, Maximilian, Philipsen, Lars, Müller, Werner, Romagnani, Chiara, Niesner, Raluca, Hauser, Anja E.

“…Innate lymphoid cells (ILCs) emerge in the last few years as important regulators of immune responses and biological processes. Although ILCs are mainly known…”
Get full text

The Role of Natural Killer Cells in Humoral Rejection by Resch, Thomas, Fabritius, Cornelia, Ebner, Susanne, Ritschl, Paul, Kotsch, Katja

“…ABSTRACTAntibody-mediated rejection (AMR) has been identified among the most important factors limiting long-term outcome in cardiac and renal transplantation…”
Get full text

Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis by Schrezenmeier, Eva, Bergfeld, Leon, Hillus, David, Lippert, Joerg-Detlev, Weber, Ulrike, Tober-Lau, Pinkus, Landgraf, Irmgard, Schwarz, Tatjana, Kappert, Kai, Stefanski, Ana-Luisa, Sattler, Arne, Kotsch, Katja, Dörner, Thomas, Sander, Leif Erik, Budde, Klemens, Halleck, Fabian, Kurth, Florian, Corman, Victor Max, Choi, Mira

“…Patients with kidney failure have notoriously weak responses to common vaccines. Thus, immunogenicity of novel SARS-CoV-2 vaccines might be impaired in this…”
Get full text

Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients by Schrezenmeier, Eva, Rincon-Arevalo, Hector, Jens, Annika, Stefanski, Ana-Luisa, Hammett, Charlotte, Osmanodja, Bilgin, Koch, Nadine, Zukunft, Bianca, Beck, Julia, Oellerich, Michael, Proß, Vanessa, Stahl, Carolin, Choi, Mira, Bachmann, Friederike, Liefeldt, Lutz, Glander, Petra, Schütz, Ekkehard, Bornemann-Kolatzki, Kirsten, López Del Moral, Covadonga, Schrezenmeier, Hubert, Ludwig, Carolin, Jahrsdörfer, Bernd, Eckardt, Kai-Uwe, Lachmann, Nils, Kotsch, Katja, Dörner, Thomas, Halleck, Fabian, Sattler, Arne, Budde, Klemens

“…Transplant recipients exhibit an impaired protective immunity after SARS-CoV-2 vaccination, potentially caused by mycophenolate (MPA) immunosuppression. Recent…”
Get full text

ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses by Topczewska, Patrycja M, Rompe, Zoe A, Jakob, Manuel O, Stamm, Anton, Leclère, Pierre S, Preußer, Alexandra, Duerr, Claudia U, Thole, Linda Marie Laura, Kotsch, Katja, Artis, David, Klose, Christoph S N

“…The initiation of type 2 immune responses at mucosal barriers is regulated by rapidly secreted cytokines called alarmins. The alarmins IL-33, IL-25 and TSLP…”
Get full text

Impact of a booster dose on SARS-CoV2 mRNA vaccine-specific humoral-, B- and T cell immunity in pediatric stem cell transplant recipients by Thole, Linda Marie Laura, Tóth, Laura, Proß, Vanessa, Siegle, Janine, Stahl, Carolin, Hermsdorf, Georg, Knabe, Annette, Winkler, Annika, Schrezenmeier, Eva, Ludwig, Carolin, Eckert, Cornelia, Eggert, Angelika, Schrezenmeier, Hubert, Sattler, Arne, Schulte, Johannes H, Kotsch, Katja

“…Stem cell transplant recipients (SCTR) are imperiled to increased risks after SARS-CoV2 infection, supporting the need for effective vaccination strategies for…”
Get full text

Expression of MICA in Zero Hour Biopsies Predicts Graft Survival After Liver Transplantation by Resch, Thomas, Hackl, Hubert, Esser, Hannah, Günther, Julia, Schwelberger, Hubert, Ritschl, Paul Viktor, Ebner, Susanne, Maglione, Manuel, Mellitzer, Vanessa, Biebl, Matthias, Öllinger, Robert, Zoller, Heinz, Schneeberger, Stefan, Kotsch, Katja

“…In search for novel biomarkers to assess graft quality, we investigated whether defined candidate genes are predictive for outcome after liver transplantation…”
Get full text

Natural Killer Cells Promote Kidney Graft Rejection Independently of Cyclosporine A Therapy by Ashraf, Muhammad Imtiaz, Sarwar, Attia, Kühl, Anja A, Hunger, Elena, Sattler, Arne, Aigner, Felix, Regele, Heinz, Sauter, Martina, Klingel, Karin, Schneeberger, Stefan, Resch, Thomas, Kotsch, Katja

“…Natural Killer (NK) cells have recently been recognized as key players in antibody-mediated chronic allograft failure, thus requiring a comprehensive…”
Get full text

Reduced mitochondrial respiration in T cells of patients with major depressive disorder by Gamradt, Stefanie, Hasselmann, Helge, Taenzer, Aline, Brasanac, Jelena, Stiglbauer, Victoria, Sattler, Arne, Sajitz-Hermstein, Max, Kierszniowska, Sylwia, Ramien, Caren, Nowacki, Jan, Mascarell-Maricic, Lea, Wingenfeld, Katja, Piber, Dominique, Ströhle, Andreas, Kotsch, Katja, Paul, Friedemann, Otte, Christian, Gold, Stefan M.

“…Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the…”
Get full text

Synergistic effects of prolonged warm ischemia and donor age on the immune response following donation after cardiac death kidney transplantation by Denecke, Christian, MD, Yuan, Xiaodong, MD, Ge, Xupeng, MD, Kim, Irene K., MD, Bedi, Daman, MD, Boenisch, Olaf, MD, Weiland, Anne, Jurisch, Anke, Kotsch, Katja, PhD, Pratschke, Johann, MD, PhD, Reutzel-Selke, Anja, PhD, Tullius, Stefan G., MD, PhD

“…Background Organs from DCD (donation after cardiac death) donors are increasingly used for transplantation. The impact of advanced donor age and warm ischemia…”
Get full text

The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy by Klingel, Karin, Fabritius, Cornelia, Sauter, Martina, Göldner, Katrin, Stauch, Diana, Kandolf, Reinhard, Ettischer, Nicole, Gahlen, Sabine, Schönberger, Tanja, Ebner, Susanne, Makrigiannis, Andrew P, Bélanger, Simon, Diefenbach, Andreas, Polić, Bojan, Pratschke, Johann, Kotsch, Katja

“…In enterovirus‐induced cardiomyopathy, information regarding the detailed impact of natural killer (NK) cells on the outcome of the disease is limited. We…”
Get full text

Prevention of Cardiac Dysfunction in Acute Coxsackievirus B3 Cardiomyopathy by Inducible Expression of a Soluble Coxsackievirus-Adenovirus Receptor by PINKERT, Sandra, WESTERMANN, Dirk, KOTSCH, Katja, WEITMANN, Kerstin, HOFFMANN, Wolfgang, SCHULTHEISS, Heinz-Peter, BRAD SPILLER, O, POLLER, Wolfgang, FECHNER, Henry, XIAOMIN WANG, KLINGEL, Karin, DÖRNER, Andrea, SAVVATIS, Konstantinos, GRÖSSL, Tobias, KROHN, Stefanie, TSCHÖPE, Carsten, ZEICHHARDT, Heinz

“…Group B coxsackieviruses (CVBs) are the prototypical agents of acute myocarditis and chronic dilated cardiomyopathy, but an effective targeted therapy is still…”
Get full text

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice by Tepeköylü, Can, Lobenwein, Daniela, Blunder, Stefan, Kozaryn, Radoslaw, Dietl, Marion, Ritschl, Paul, Pechriggl, Elisabeth J., Blumer, Michael J.F., Bitsche, Mario, Schistek, Roland, Kotsch, Katja, Fritsch, Helga, Grimm, Michael, Holfeld, Johannes

“…OBJECTIVES Tissue-engineered xenografts represent a promising treatment option in heart valve disease. However, inflammatory response leading to graft failure…”
Get full text

Graft Pre-conditioning by Peri-Operative Perfusion of Kidney Allografts With Rabbit Anti-human T-lymphocyte Globulin Results in Improved Kidney Graft Function in the Early Post-transplantation Period-a Prospective, Randomized Placebo-Controlled Trial by Ritschl, Paul V, Günther, Julia, Hofhansel, Lena, Kühl, Anja A, Sattler, Arne, Ernst, Stefanie, Friedersdorff, Frank, Ebner, Susanne, Weiss, Sascha, Bösmüller, Claudia, Weissenbacher, Annemarie, Oberhuber, Rupert, Cardini, Benno, Öllinger, Robert, Schneeberger, Stefan, Biebl, Matthias, Denecke, Christian, Margreiter, Christian, Resch, Thomas, Aigner, Felix, Maglione, Manuel, Pratschke, Johann, Kotsch, Katja

“…Although prone to a higher degree of ischemia reperfusion injury (IRI), the use of extended criteria donor (ECD) organs has become reality in transplantation…”
Get full text

Targeting of natural killer cells by rabbit antithymocyte globulin and campath-1H: similar effects independent of specificity by Stauch, Diana, Dernier, Annelie, Sarmiento Marchese, Elizabeth, Kunert, Kristina, Volk, Hans-Dieter, Pratschke, Johann, Kotsch, Katja

“…T cell depleting strategies are an integral part of immunosuppressive regimens widely used in the hematological and solid organ transplant setting. Although it…”
Get full text

Inhibition of Dendritic Cell Maturation and Function Is Independent of Heme Oxygenase 1 but Requires the Activation of STAT3 by Mashreghi, Mir-Farzin, Klemz, Roman, Knosalla, Isabela Schmitt, Gerstmayer, Bernhard, Janssen, Uwe, Buelow, Roland, Jozkowicz, Alicja, Dulak, Jozef, Volk, Hans-Dieter, Kotsch, Katja

“…The induction of heme oxygenase 1 (HO-1) by a single treatment with cobalt protoporphyrin (CoPPIX) protects against inflammatory liver failure and ischemia…”
Get full text

NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy by Streitz, Mathias, Noutsias, Michel, Volkmer, Rudolf, Rohde, Maria, Brestrich, Gordon, Block, Andrea, Klippert, Katrin, Kotsch, Katja, Ay, Bernhard, Hummel, Michael, Kühl, Uwe, Lassner, Dirk, Schultheiss, Heinz-Peter, Volk, Hans-Dieter, Kern, Florian

“…Parvovirus B19 (B19V) is the most commonly detected virus in endomyocardial biopsies (EMBs) from patients with inflammatory cardiomyopathy (DCMi). Despite the…”
Get full text

Amplifying the fluorescence of bilirubin enables the real-time detection of heme oxygenase activity by Klemz, Roman, Mashreghi, Mir-Farzin, Spies, Claudia, Volk, Hans-Dieter, Kotsch, Katja

“…Heme oxygenases (HO) are the rate-limiting enzymes in the degradation of heme to equimolar amounts of antioxidant bile pigments, the signaling molecule carbon…”
Get full text

Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction by NEY AGUIAR MARTINS, Paulo, REUTZEI-SEIKE, Anja, TULLIUS, Stefan G, JURISCH, Anke, DENECKE, Christian, ATTROT, Kirstin, PASCHER, Andreas, KOTSCH, Katja, PRATSCHKE, Johann, NEUHAUS, Peter, VOLK, Hans-Dieter

“…Nonspecific inflammatory damages occurring prior to organ transplantation reduce long-term graft survival. Here, we tested the beneficial effects of carbon…”
Get full text