Search Results - "KOTLYAR, Alina"

Folate‐targeted nanoparticles show efficacy in the treatment of inflammatory arthritis by Thomas, Thommey P., Goonewardena, Sascha N., Majoros, Istvan J., Kotlyar, Alina, Cao, Zhengyi, Leroueil, Pascale R., Baker, James R.

“…Objective To investigate the uptake of a poly(amidoamine) dendrimer (generation 5 [G5]) nanoparticle covalently conjugated to polyvalent folic acid (FA) as the…”
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Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate by Choi, Seok Ki, Thomas, Thommey, Li, Ming-Hsin, Kotlyar, Alina, Desai, Ankur, Baker, Jr, James R

“…We report the synthesis and in vitro evaluation of folate receptor-targeted nanoconjugate that releases its therapeutic payload via a photochemical mechanism…”
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Cationic Poly(amidoamine) Dendrimer Induces Lysosomal Apoptotic Pathway at Therapeutically Relevant Concentrations by Thomas, Thommey P, Majoros, Istvan, Kotlyar, Alina, Mullen, Douglas, Banaszak Holl, Mark M, Baker, James R

“…Poly(amidoamine) (PAMAM) dendrimers carrying different amounts of surface amino groups were synthesized and tested for their effects on cellular cytotoxicity,…”
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Synthesis, characterization, and intracellular uptake of carboxyl-terminated poly(amidoamine) dendrimer-stabilized iron oxide nanoparticles by Shi, Xiangyang, Thomas, Thommey P, Myc, Lukasz A, Kotlyar, Alina, Baker, Jr, James R

“…We report the synthesis and characterization of a group of carboxyl-functionalized poly(amidoamine) (PAMAM) dendrimers of generation 3 (G3) that were used for…”
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Targeting and Inhibition of Cell Growth by an Engineered Dendritic Nanodevice by Thomas, Thommey P, Majoros, Istvan J, Kotlyar, Alina, Kukowska-Latallo, Jolanta F, Bielinska, Anna, Myc, Andrzej, Baker, James R

“…The cellular uptake and cytotoxicity of an engineered multifunctional dendritic nanodevice containing folic acid (FA) as the targeting molecule, methotrexate…”
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Avidity Modulation of Folate-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles by Silpe, Justin E, Sumit, Madhuresh, Thomas, Thommey P, Huang, Baohua, Kotlyar, Alina, van Dongen, Mallory A, Banaszak Holl, Mark M, Orr, Bradford G, Choi, Seok Ki

“…We investigated two types of generation 5 polyamidoamine (PAMAM) dendrimers, each conjugated stochastically with a mean number of 5 or 10 methotrexate (MTX)…”
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Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic by Thomas, Thommey P, Joice, Melvin, Sumit, Madhuresh, Silpe, Justin E, Kotlyar, Alina, Bharathi, Sophia, Kukowska-Latallo, Jolanta, Baker, James R, Choi, Seok Ki

“…Design of cancer-targeting nanotherapeutics relies on a pair of two functionally orthogonal molecules, one serving as a cancer cell-specific targeting ligand,…”
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Sustained Analgesia Achieved Through Esterase-Activated Morphine Prodrugs Complexed with PAMAM Dendrimer by Ward, Brent B., Huang, Baohua, Desai, Ankur, Cheng, Xue-Min, Vartanian, Mark, Zong, Hong, Shi, Xiangyang, Thomas, Thommey P., Kotlyar, Alina E., Van Der Spek, Abraham, Leroueil, Pascale R., Baker, James R.

“…ABSTRACT Purpose Design and evaluate the in vitro and in vivo efficacy of two extended release morphine formulations developed for IV administration by…”
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Detection and Analysis of Tumor Fluorescence Using a Two-Photon Optical Fiber Probe by Thomas, Thommey P., Myaing, Mon Thiri, Ye, Jing Yong, Candido, Kimberly, Kotlyar, Alina, Beals, James, Cao, Peter, Keszler, Balazs, Patri, Anil K., Norris, Theodore B., Baker, James R.

“…The utility of a two-photon optical fiber fluorescence probe (TPOFF) for sensing and quantifying tumor fluorescent signals was tested in vivo. Xenograft tumors…”
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Micro chromosomal deletions at the NYS7 locus and autosomal dominant nystagmus by Hecht, Idan, Weiner, Chen, Kotlyar, Alina, Shoshany, Nadav, Pras, Eran

“…Nystagmus is an ocular condition characterized by bilateral involuntary ocular oscillation which can severely affect vision. When not associated with other…”
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PSMA-Targeted Stably Linked “Dendrimer-Glutamate Urea-Methotrexate” as a Prostate Cancer Therapeutic by Huang, Baohua, Otis, James, Joice, Melvin, Kotlyar, Alina, Thomas, Thommey P

“…One of the important criteria for achieving efficient nanoparticle-based targeted drug delivery is that the drug is not prematurely released at off-target…”
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Variants in the WDR45 Gene Within the OPA-2 Locus Associate With Isolated X-Linked Optic Atrophy by Gazit, Inbal, Hecht, Idan, Weiner, Chen, Kotlyar, Alina, Almer, Zina, Bakshi, Erez, Or, Lior, Volkov, Hadas, Feldman, Barak, Maharshak, Idit, Michelson, Marina, Goldenberg-Cohen, Nitza, Pras, Eran

“…To describe clinical and molecular findings of two families with X-linked optic atrophy and present two new pathogenic variants in the WDR45 gene.PurposeTo…”
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Connective tissue activation XXXVIII: heparin/heparanase activity of human platelets resides in a high molecular weight protein, not in connective tissue activating peptide III by CASTOR, C. William, KOTLYAR, Alina, EDWARDS, Brian E

“…OBJECTIVE: Connective tissue activating protein-III (CTAP-III), with molecular weight 9278 Da and isoforms including CTAP-III des 1-15 (neutrophil activating…”
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Polyvalent Dendrimer-Methotrexate as a Folate Receptor-Targeted Cancer Therapeutic by Thomas, Thommey P, Huang, Baohua, Choi, Seok Ki, Silpe, Justin E, Kotlyar, Alina, Desai, Ankur M, Zong, Hong, Gam, Jeremy, Joice, Melvin, Baker, James R

“…Our previous studies have demonstrated that a generation 5 dendrimer (G5) conjugated with both folic acid (FA) and methotrexate (MTX) has a higher…”
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Dendrimer-Based Multivalent Vancomycin Nanoplatform for Targeting the Drug-Resistant Bacterial Surface by Choi, Seok Ki, Myc, Andrzej, Silpe, Justin Ezekiel, Sumit, Madhuresh, Wong, Pamela Tinmoi, McCarthy, Kelly, Desai, Ankur M, Thomas, Thommey P, Kotlyar, Alina, Holl, Mark M. Banaszak, Orr, Bradford G, Baker, James R

“…Vancomycin represents the preferred ligand for bacteria-targeting nanosystems. However, it is inefficient for emerging vancomycin-resistant species because of…”
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Association of Variants in TMEM45A With Keratoglobus by Weiner, Chen, Hecht, Idan, Kotlyar, Alina, Shoshany, Nadav, Zadok, David, Elbaz, Uri, Segev, Fani, Maytal, Anat, Hachmo, Yafit, Michiels, Carine, De Backer, Olivier, Shomron, Noam, Einan-Lifshitz, Adi, Pras, Eran

“…Keratoglobus is a rare corneal disorder characterized by generalized thinning and globular protrusion of the cornea. Affected individuals typically have…”
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Synthesis and Functional Evaluation of DNA-Assembled Polyamidoamine Dendrimer Clusters for Cancer Cell-Specific Targeting by Choi, Youngseon, Thomas, Thommey, Kotlyar, Alina, Islam, Mohammad T., Baker, James R.

“…We sought to produce dendrimers conjugated to different biofunctional moieties (fluorescein [FITC] and folic acid [FA]), and then link them together using…”
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Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio by Zong, Hong, Thomas, Thommey P, Lee, Kyung-Hoon, Desai, Ankur M, Li, Ming-hsin, Kotlyar, Alina, Zhang, Yuehua, Leroueil, Pascale R, Gam, Jeremy J, Banaszak Holl, Mark M, Baker, James R

“…Our group previously developed a multifunctional, targeted cancer therapeutic based on Generation 5 (G5) polyamidoamine (PAMAM) dendrimers. In those studies we…”
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Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates by Shukla, Rameshwer, Thomas, Thommey P, Peters, Jennifer, Kotlyar, Alina, Myc, Andrzej, Baker, Jr, James R

“…PAMAM dendrimer-RGD-4C peptide conjugate was synthesized and in vitro targeting efficacy to integrin receptor expressing cells was studied by flow cytometry…”
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Synthesis, Characterization, and in Vitro Testing of Superparamagnetic Iron Oxide Nanoparticles Targeted Using Folic Acid-Conjugated Dendrimers by Landmark, Kevin J, DiMaggio, Stassi, Ward, Jesse, Kelly, Christopher, Vogt, Stefan, Hong, Seungpyo, Kotlyar, Alina, Myc, Andrzej, Thomas, Thommey P, Penner-Hahn, James E, Baker, James R, Holl, Mark M. Banaszak, Orr, Bradford G

“…Organic-coated superparamagnetic iron oxide nanoparticles (OC-SPIONs) were synthesized and characterized by transmission electron microscopy and X-ray…”
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