Search Results - "KOTEVA, Kalinka"

A diverse intrinsic antibiotic resistome from a cave bacterium by Pawlowski, Andrew C., Wang, Wenliang, Koteva, Kalinka, Barton, Hazel A., McArthur, Andrew G., Wright, Gerard D.

“…Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural…”
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The Comprehensive Antibiotic Resistance Database by MCARTHUR, Andrew G, WAGLECHNER, Nicholas, KALAN, Lindsay, KING, Andrew M, KOTEVA, Kalinka, MORAR, Mariya, MULVEY, Michael R, O'BRIEN, Jonathan S, PAWLOWSKI, Andrew C, PIDDOCK, Laura J. V, SPANOGIANNOPOULOS, Peter, SUTHERLAND, Arlene D, NIZAM, Fazmin, TANG, Irene, TAYLOR, Patricia L, THAKER, Maulik, WENLIANG WANG, YAN, Marie, YU, Tennison, WRIGHT, Gerard D, YAN, Austin, AZAD, Marisa A, BAYLAY, Alison J, BHULLAR, Kirandeep, CANOVA, Marc J, DE PASCALE, Gianfranco, EJIM, Linda

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Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes by Sychantha, David, Chen, Xuefei, Koteva, Kalinka, Prehna, Gerd, Wright, Gerard D.

“…Microbial Ni 2+ homeostasis underpins the virulence of several clinical pathogens. Ni 2+ is an essential cofactor in urease and [NiFe]-hydrogenases involved in…”
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Antibiotic resistance is prevalent in an isolated cave microbiome by Bhullar, Kirandeep, Waglechner, Nicholas, Pawlowski, Andrew, Koteva, Kalinka, Banks, Eric D, Johnston, Michael D, Barton, Hazel A, Wright, Gerard D

“…Antibiotic resistance is a global challenge that impacts all pharmaceutically used antibiotics. The origin of the genes associated with this resistance is of…”
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A Common Platform for Antibiotic Dereplication and Adjuvant Discovery by Cox, Georgina, Sieron, Arthur, King, Andrew M, De Pascale, Gianfranco, Pawlowski, Andrew C, Koteva, Kalinka, Wright, Gerard D

“…Solving the antibiotic resistance crisis requires the discovery of new antimicrobial drugs and the preservation of existing ones. The discovery of inhibitors…”
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rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria by Spanogiannopoulos, Peter, Waglechner, Nicholas, Koteva, Kalinka, Wright, Gerard D.

“…Many environmental bacteria are multidrug-resistant and represent a reservoir of ancient antibiotic resistance determinants, which have been linked to genes…”
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The evolution of substrate discrimination in macrolide antibiotic resistance enzymes by Pawlowski, Andrew C., Stogios, Peter J., Koteva, Kalinka, Skarina, Tatiana, Evdokimova, Elena, Savchenko, Alexei, Wright, Gerard D.

“…The production of antibiotics by microbes in the environment and their use in medicine and agriculture select for existing and emerging resistance. To address…”
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ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin by Bordeleau, Emily, Stogios, Peter J, Evdokimova, Elena, Koteva, Kalinka, Savchenko, Alexei, Wright, Gerard D

“…Apramycin is an aminoglycoside antibiotic with the potential to be developed to combat multidrug-resistant pathogens. Its unique structure evades the…”
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Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes by Cox, Georgina, Ejim, Linda, Stogios, Peter J., Koteva, Kalinka, Bordeleau, Emily, Evdokimova, Elena, Sieron, Arthur O., Savchenko, Alexei, Serio, Alisa W., Krause, Kevin M., Wright, Gerard D.

“…Plazomicin is a next-generation, semisynthetic aminoglycoside antibiotic currently under development for the treatment of infections due to multidrug-resistant…”
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Rifampin phosphotransferase is an unusual antibiotic resistance kinase by Stogios, Peter J., Cox, Georgina, Spanogiannopoulos, Peter, Pillon, Monica C., Waglechner, Nicholas, Skarina, Tatiana, Koteva, Kalinka, Guarné, Alba, Savchenko, Alexei, Wright, Gerard D.

“…Rifampin (RIF) phosphotransferase (RPH) confers antibiotic resistance by conversion of RIF and ATP, to inactive phospho-RIF, AMP and P i . Here we present the…”
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TetX Is a Flavin-dependent Monooxygenase Conferring Resistance to Tetracycline Antibiotics by Yang, Wangrong, Moore, Ian F, Koteva, Kalinka P, Bareich, David C, Hughes, Donald W, Wright, Gerard D

“…The tetracycline antibiotics block microbial translation and constitute an important group of antimicrobial agents that find broad clinical utility. Resistance…”
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Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes by SPANOGIANNOPOULOS, Peter, THAKER, Maulik, KOTEVA, Kalinka, WAGLECHNER, Nicholas, WRIGHT, Gerard D

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A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor by Wright, Gerard D, Koteva, Kalinka, Hong, Hee-Jeon, Wang, Xiao Dong, Nazi, Ishac, Hughes, Donald, Naldrett, Mike J, Buttner, Mark J

“…Inducible resistance to the glycopeptide antibiotic vancomycin requires expression of vanH, vanA and vanX, controlled by a two-component regulatory system…”
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Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr by Baysarowich, Jennifer, Koteva, Kalinka, Hughes, Donald W, Ejim, Linda, Griffiths, Emma, Zhang, Kun, Junop, Murray, Wright, Gerard D

“…The rifamycin antibiotic rifampin is important for the treatment of tuberculosis and infections caused by multidrug-resistant Staphylococcus aureus. Recent…”
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Glycopeptide Sulfation Evades Resistance by Kalan, Lindsay, Perry, Julie, Koteva, Kalinka, Thaker, Maulik, Wright, Gerard

“…The incidence of antibiotic resistance among pathogenic microorganisms is increasing at an alarming rate. Resistance against front-line therapeutics such as…”
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Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity by Yarlagadda, Venkateswarlu, Medina, Ricardo, Johnson, Timothy A, Koteva, Kalinka P, Cox, Georgina, Thaker, Maulik N, Wright, Gerard D

“…The rise of bacterial antibiotic resistance coupled with a diminished antibiotic drug pipeline underlines the importance of developing rational strategies to…”
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Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1 by McKenzie, Nancy L, Thaker, Maulik, Koteva, Kalinka, Hughes, Donald W, Wright, Gerard D, Nodwell, Justin R

“…The bacterial genus Streptomyces is endowed with a remarkable secondary metabolism that generates an enormous number of bioactive small molecules. Many of…”
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Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms by D'Costa, Vanessa M, Mukhtar, Tariq A, Patel, Tejal, Koteva, Kalinka, Waglechner, Nicholas, Hughes, Donald W, Wright, Gerard D, De Pascale, Gianfranco

“…The lipopeptide daptomycin is a member of the newest FDA-approved antimicrobial class, exhibiting potency against a broad range of Gram-positive pathogens with…”
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Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A by Koteva, Kalinka, Sychantha, David, Rotondo, Caitlyn M, Hobson, Christian, Britten, James F, Wright, Gerard D

“…The aminopolycarboxylic acid aspergillomarasmine A (AMA) is a natural Zn2+ metallophore and inhibitor of metallo-β-lactamases (MBLs) which reverses β-lactam…”
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Small-Molecule Modulators of Listeria monocytogenes Biofilm Development by NGUYEN, Uyen T, WENDERSKA, Iwona B, CHONG, Matthew A, KOTEVA, Kalinka, WRIGHT, Gerard D, BURROWS, Lori L

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