Search Results - "KOTECKA, Barbara"

First Assessment in Humans of the Safety, Tolerability, Pharmacokinetics, and Ex Vivo Pharmacodynamic Antimalarial Activity of the New Artemisinin Derivative Artemisone by NAGELSCHMITZ, Johannes, VOITH, Barbara, WENSING, Georg, ROEMER, Axel, FUGMANN, Burkhard, HAYNES, Richard K, KOTECKA, Barbara M, RIECKMANN, Karl H, EDSTEIN, Michael D

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Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class by Haynes, Richard K., Fugmann, Burkhard, Stetter, Jörg, Rieckmann, Karl, Heilmann, Hans-Dietrich, Chan, Ho-Wai, Cheung, Man-Ki, Lam, Wai-Lun, Wong, Ho-Ning, Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Peters, Wallace, Robinson, Brian L., Edstein, Michael D., Kotecka, Barbara, Kyle, Dennis E., Beckermann, Bernhard, Gerisch, Michael, Radtke, Martin, Schmuck, Gabriele, Steinke, Wolfram, Wollborn, Ute, Schmeer, Karl, Römer, Axel

“…Artemisinin—the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin “gold…”
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Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum by OBALDIA, Nicanor, KOTECKA, Barbara M, EDSTEIN, Michael D, HAYNES, Richard K, FUGMANN, Burkhard, KYLE, Dennis E, RIECKMANN, Karl H

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Simple In Vitro Assay for Determining the Sensitivity of Plasmodium vivax Isolates from Fresh Human Blood to Antimalarials in Areas where P. vivax Is Endemic by RUSSELL, Bruce M, UDOMSANGPETCH, Rachanee, RIECKMANN, Karl H, KOTECKA, Barbara M, COLEMAN, Russell E, SATTABONGKOT, Jetsumon

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Phenoxypropoxybiguanides, Prodrugs of DHFR−Inhibiting Diaminotriazine Antimalarials by Jensen, Norman P, Ager, Arba L, Bliss, Robert A, Canfield, Craig J, Kotecka, Barbara M, Rieckmann, Karl H, Terpinski, Jacek, Jacobus, David P

“…A total of 34 analogues of the biguanide PS-15 (5s), a prodrug of the diaminotriazine WR-99210 (8s), have been prepared. Several of them, such as 5b (PS-33)…”
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Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate—JPC2056—in cynomolgus monkeys using an in vivo–in vitro model by Edstein, Michael D., Kotecka, Barbara M., Ager, Arba L., Smith, Kirsten S., DiTusa, Charles A., Diaz, Damaris S., Kyle, Dennis E., Schiehser, Guy A., Jacobus, David P., Rieckmann, Karl H., O'Neil, Michael T.

“…Objectives To assess the antimalarial pharmacodynamics and pharmacokinetics of the novel dihydrofolate reductase (DHFR) inhibitor, JPC2056 and its principal…”
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Mutations in Plasmodium falciparumCytochrome b That Are Associated with Atovaquone Resistance Are Located at a Putative Drug-Binding Site by Korsinczky, Michael, Chen, Nanhua, Kotecka, Barbara, Saul, Allan, Rieckmann, Karl, Cheng, Qin

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Inhibition of taurocholate and ouabain transport in isolated rat hepatocytes by cyclosporin A by Stacey, N H, Kotecka, B

“…The use of cyclosporin A in transplantation procedures has been reported to cause hepatotoxicity as evidenced by elevated serum bilirubin and bile salt levels…”
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Mutations in Plasmodium falciparum cytochrome b that are associated with Atovaquone resistance are located at a putative drug-binding site by KORSINCZKY, M, NANHUA CHEN, KOTECKA, B, SAUL, A, RIECKMANN, K, QIN CHENG

“…Atovaquone is the major active component of the new antimalarial drug Malarone. Considerable evidence suggests that malaria parasites become resistant to…”
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Chloroquine bioassay using malaria microcultures by Kotecka, B M, Rieckmann, K H

“…The in vitro microculture technique was used to develop a relatively simple bioassay for estimating chloroquine (CQ) in plasma or serum. Chloroquine…”
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Plasma chloroquine concentrations in young and older malaria patients treated with chloroquine by Maitland, Kathryn, Williams, Thomas N, Kotecka, Barbara M, Edstein, Michael D, Rieckmann, Karl H

“…Plasma chloroquine (CQ) concentrations were measured by bioassay in young (0–4 years, n=9) and older (5–60 years, n=21) patients from Vanuatu infected with…”
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Substrate transport and cyclosporin A in isolated rat hepatocytes by Kukongviriyapan, V, Kotecka, B, Stacey, N H

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Sequence Polymorphisms in pfcrt Are Strongly Associated with Chloroquine Resistance in Plasmodium falciparum by Chen, Nanhua, Russell, Bruce, Staley, John, Kotecka, Barbara, Nasveld, Peter, Cheng, Qin

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Lack of in vitro effect of ivermectin on Plasmodium falciparum by NASVELD, Peter, RUSSELL, Bruce, KOTECKA, Barbara, RIECKMANN, Karl

“…The in vitro activity of ivermectin was assessed against the K1 isolate of Plasmodium falciparum. The mean IC50 and IC90 of ivermectin were 8.0 and 35.0…”
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Cover Picture: Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. Int. Ed. 13/2006) by Haynes, Richard K., Fugmann, Burkhard, Stetter, Jörg, Rieckmann, Karl, Heilmann, Hans-Dietrich, Chan, Ho-Wai, Cheung, Man-Ki, Lam, Wai-Lun, Wong, Ho-Ning, Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Peters, Wallace, Robinson, Brian L., Edstein, Michael D., Kotecka, Barbara, Kyle, Dennis E., Beckermann, Bernhard, Gerisch, Michael, Radtke, Martin, Schmuck, Gabriele, Steinke, Wolfram, Wollborn, Ute, Schmeer, Karl, Römer, Axel

“…Qing hao su, or artemisinin, is the active compound isolated from the herb Artemisia annua (qīng hāo) shown in the cover picture. The Chinese text shown…”
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New quinoline di-Mannich base compounds with greater antimalarial activity than chloroquine, amodiaquine, or pyronaridine by Kotecka, B M, Barlin, G B, Edstein, M D, Rieckmann, K H

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Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides by Strekowski, Lucjan, Zegrocka, Oliwia, Henary, Maged, Say, Martial, Mokrosz, Maria J., Kotecka, Barbara M., Manzel, Lori, Macfarlane, Donald E.

“…On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the…”
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Titelbild: Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. 13/2006) by Haynes, Richard K., Fugmann, Burkhard, Stetter, Jörg, Rieckmann, Karl, Heilmann, Hans‐Dietrich, Chan, Ho‐Wai, Cheung, Man‐Ki, Lam, Wai‐Lun, Wong, Ho‐Ning, Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Peters, Wallace, Robinson, Brian L., Edstein, Michael D., Kotecka, Barbara, Kyle, Dennis E., Beckermann, Bernhard, Gerisch, Michael, Radtke, Martin, Schmuck, Gabriele, Steinke, Wolfram, Wollborn, Ute, Schmeer, Karl, Römer, Axel

“…Qing hao su, oder Artemisinin, ist die aktive Verbindung aus der auf dem Titelbild gezeigten Beifußart Artemisia annua (qīng hāo). Der chinesische Text aus der…”
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Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class by Haynes, Richard K., Fugmann, Burkhard, Stetter, Jörg, Rieckmann, Karl, Heilmann, Hans-Dietrich, Chan, Ho-Wai, Cheung, Man-Ki, Lam, Wai-Lun, Wong, Ho-Ning, Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Peters, Wallace, Robinson, Brian L., Edstein, Michael D., Kotecka, Barbara, Kyle, Dennis E., Beckermann, Bernhard, Gerisch, Michael, Radtke, Martin, Schmuck, Gabriele, Steinke, Wolfram, Wollborn, Ute, Schmeer, Karl, Römer, Axel

“…Artemisinin – die nächste Generation: Artemisone ist gegen den Malariaparasiten erheblich wirksamer als der derzeitige Artemisinin‐„Goldstandard“, Artesunat…”
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Chloroquine bioassay of plasma specimens obtained from soldiers on chloroquine plus doxycycline for malaria prophylaxis by Kotecka, Barbara M., Edstein, Michael D., Rieckmann, Karl H.

“…In this study we describe the application of a bioassay for measuring chloroquine equivalent concentrations in plasma samples obtained from soldiers on…”
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