Search Results - "KOTAS, Maya E"

Homeostasis, Inflammation, and Disease Susceptibility by Kotas, Maya E., Medzhitov, Ruslan

“…While modernization has dramatically increased lifespan, it has also witnessed the increasing prevalence of diseases such as obesity, hypertension, and type 2…”
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Central Serotonergic Neurons Activate and Recruit Thermogenic Brown and Beige Fat and Regulate Glucose and Lipid Homeostasis by McGlashon, Jacob M., Gorecki, Michelle C., Kozlowski, Amanda E., Thirnbeck, Caitlin K., Markan, Kathleen R., Leslie, Kirstie L., Kotas, Maya E., Potthoff, Matthew J., Richerson, George B., Gillum, Matthew P.

“…Thermogenic brown and beige adipocytes convert chemical energy to heat by metabolizing glucose and lipids. Serotonin (5-HT) neurons in the CNS are essential…”
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SirT1 Regulates Adipose Tissue Inflammation by GILLUM, Matthew P, KOTAS, Maya E, BANKS, Alexander S, LI QIANG, BHANOT, Sanjay, OLEFSKY, Jerrold M, SEARS, Dorothy D, CAPRIO, Sonia, SHULMAN, Gerald I, ERION, Derek M, KURSAWE, Romy, CHATTERJEE, Paula, NEAD, Kevin T, MUISE, Eric S, HSIAO, Jennifer J, FREDERICK, David W, YONEMITSU, Shin

“…Macrophage recruitment to adipose tissue is a reproducible feature of obesity. However, the events that result in chemokine production and macrophage…”
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Innate type 2 immunity controls hair follicle commensalism by Demodex mites by Ricardo-Gonzalez, Roberto R., Kotas, Maya E., O’Leary, Claire E., Singh, Katelyn, Damsky, William, Liao, Chang, Arouge, Elizabeth, Tenvooren, Iliana, Marquez, Diana M., Schroeder, Andrew W., Cohen, Jarish N., Fassett, Marlys S., Lee, Jinwoo, Daniel, Scott G., Bittinger, Kyle, Díaz, Roberto Efraín, Fraser, James S., Ali, Niwa, Ansel, K. Mark, Spitzer, Matthew H., Liang, Hong-Erh, Locksley, Richard M.

“…Demodex mites are commensal parasites of hair follicles (HFs). Normally asymptomatic, inflammatory outgrowth of mites can accompany malnutrition, immune…”
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CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone by Kotas, Maya E., Mroz, Nicholas M., Koga, Satoshi, Liang, Hong-Erh, Schroeder, Andrew W., Ricardo-Gonzalez, Roberto R., Schneider, Christoph, Locksley, Richard M.

“…Innate lymphoid cells (ILCs) are tissue-resident effectors poised to activate rapidly in response to local signals such as cytokines. To preserve homeostasis,…”
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Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair by Barr, Justinn, Gentile, Maria Elena, Lee, Sunyoung, Kotas, Maya E, Fernanda de Mello Costa, Maria, Holcomb, Nicolas P, Jaquish, Abigail, Palashikar, Gargi, Soewignjo, Marcella, McDaniel, Margaret, Matsumoto, Ichiro, Margolskee, Robert, Von Moltke, Jakob, Cohen, Noam A, Sun, Xin, Vaughan, Andrew E

“…While the lung bears significant regenerative capacity, severe viral pneumonia can chronically impair lung function by triggering dysplastic remodeling. The…”
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Role of caspase-1 in regulation of triglyceride metabolism by Kotas, Maya E., Jurczak, Michael J., Annicelli, Charles, Gillum, Matthew P., Cline, Gary W., Shulman, Gerald I., Medzhitov, Ruslan

“…Caspase-1 is a cysteine protease that can be activated by both endogenous and exogenous inflammatory stimuli and has been shown to have important functions in…”
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Impact of CD1d deficiency on metabolism by Kotas, Maya E, Lee, Hui-Young, Gillum, Matthew P, Annicelli, Charles, Guigni, Blas A, Shulman, Gerald I, Medzhitov, Ruslan

“…Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like…”
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IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function by Kotas, Maya E, Moore, Camille M, Gurrola, 2nd, Jose G, Pletcher, Steven D, Goldberg, Andrew N, Alvarez, Raquel, Yamato, Sheyla, Bratcher, Preston E, Shaughnessy, Ciaran A, Zeitlin, Pamela L, Zhang, Irene H, Li, Yingchun, Montgomery, Michael T, Lee, Keehoon, Cope, Emily K, Locksley, Richard M, Seibold, Max A, Gordon, Erin D

“…Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are…”
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A role for IL-33-activated ILC2s in eosinophilic vasculitis by Kotas, Maya E, Dion, Jérémie, Van Dyken, Steven, Ricardo-Gonzalez, Roberto R, Danel, Claire J, Taillé, Camille, Mouthon, Luc, Locksley, Richard M, Terrier, Benjamin

“…Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare but serious disease with poorly understood mechanisms. Here, we report that patients with EGPA…”
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Why Innate Lymphoid Cells? by Kotas, Maya E., Locksley, Richard M.

“…Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express receptors responsive to their organ microenvironments, and perform…”
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Quantifying behavioural interactions between humans and mosquitoes: evaluating the protective efficacy of insecticidal nets against malaria transmission in rural Tanzania by Killeen, Gerry F, Kihonda, Japhet, Lyimo, Edith, Oketch, Fred R, Kotas, Maya E, Mathenge, Evan, Schellenberg, Joanna A, Lengeler, Christian, Smith, Thomas A, Drakeley, Chris J

“…African malaria vectors bite predominantly indoors at night so sleeping under an Insecticide-Treated Net (ITN) can greatly reduce malaria risk. Behavioural…”
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cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 2 (CRTC2) Promotes Glucagon Clearance and Hepatic Amino Acid Catabolism to Regulate Glucose Homeostasis by Erion, Derek M., Kotas, Maya E., McGlashon, Jacob, Yonemitsu, Shin, Hsiao, Jennifer J., Nagai, Yoshio, Iwasaki, Takanori, Murray, Susan F., Bhanot, Sanjay, Cline, Gary W., Samuel, Varman T., Shulman, Gerald I., Gillum, Matthew P.

“…cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) regulates transcription of gluconeogenic genes by specifying…”
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Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage by Kotas, Maya E, O'Leary, Claire E, Locksley, Richard M

“…Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional…”
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Mesenchymal stromal cells and macrophages in sepsis: new insights by Kotas, Maya E, Matthay, Michael A

“…Sepsis is a syndrome of acute organ dysfunction caused by the physiologic and pathophysiologic response to infection [1–3]. Although the specific clinical…”
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Toward Optimal Acute Respiratory Distress Syndrome Outcomes: Recognizing the Syndrome and Identifying Its Causes by Kotas, Maya E, Thompson, B Taylor

“…Acute respiratory distress syndrome is a common condition among critically ill patients, but remains under-recognized and undertreated. Under-recognition may…”
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IL-13–associated epithelial remodeling correlates with clinical severity in nasal polyposis by Kotas, Maya E., Patel, Neil N., Cope, Emily K., Gurrola, Jose G., Goldberg, Andrew N., Pletcher, Steven D., Seibold, Max A., Moore, Camille M., Gordon, Erin D.

“…Epithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell-type shifts and their…”
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Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior by Barron, Jerika J, Mroz, Nicholas M, Taloma, Sunrae E, Dahlgren, Madelene W, Ortiz-Carpena, Jorge F, Keefe, Matthew G, Escoubas, Caroline C, Dorman, Leah C, Vainchtein, Ilia D, Chiaranunt, Pailin, Kotas, Maya E, Nowakowski, Tomasz J, Bender, Kevin J, Molofsky, Ari B, Molofsky, Anna V

“…The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and…”
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Bile acid-sensitive tuft cells regulate biliary neutrophil influx by O'Leary, Claire E, Sbierski-Kind, Julia, Kotas, Maya E, Wagner, Johanna C, Liang, Hong-Erh, Schroeder, Andrew W, de Tenorio, Jeshua C, von Moltke, Jakob, Ricardo-Gonzalez, Roberto R, Eckalbar, Walter L, Molofsky, Ari B, Schneider, Christoph, Locksley, Richard M

“…Inflammation and dysfunction of the extrahepatic biliary tree are common causes of human pathology, including gallstones and cholangiocarcinoma. Despite this,…”
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Sirtuin-1 is a nutrient-dependent modulator of inflammation by Kotas, Maya E., Gorecki, Michelle C., Gillum, Matthew P.

“…Inflammation accompanies obesity and its comorbidities-type 2 diabetes, non-alcoholic fatty liver disease and atherosclerosis, among others-and may contribute…”
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