Search Results - "KOTAKA, Masayo"

Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer by Cheung, Yee-Wai, Kwok, Jane, Law, Alan W. L., Watt, Rory M., Kotaka, Masayo, Tanner, Julian A.

“…DNA aptamers have significant potential as diagnostic and therapeutic agents, but the paucity of DNA aptamer-target structures limits understanding of their…”
Get full text

Insights from the Structure of an Active Form of Bacillus thuringiensis Cry5B by Li, Jiaxin, Wang, Lin, Kotaka, Masayo, Lee, Marianne M, Chan, Michael K

“…The crystal protein Cry5B, a pore-forming protein produced by the soil bacterium , has been demonstrated to have excellent anthelmintic activity. While a…”
Get full text

Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage by YI WANG, DUTTA, Sujit, KARLBERG, Helen, DEVIGNOT, Stephanie, WEBER, Friedemann, QUAN HAO, YEE JOO TAN, MIRAZIMI, Ali, KOTAKA, Masayo

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Functional Role of a Conserved Loop in EAL Domain-Based Cyclic di-GMP-Specific Phosphodiesterase by FENG RAO, YANING QI, HUI SHAN CHONG, KOTAKA, Masayo, BIN LI, JINMING LI, LESCAR, Julien, KAI TANG, LIANG, Zhao-Xun

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38 by Graeff, Richard, Liu, Qun, Kriksunov, Irina A., Kotaka, Masayo, Oppenheimer, Norman, Hao, Quan, Lee, Hon Cheung

“…Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes that catalyze the synthesis and hydrolysis of cyclic…”
Get full text

Structural Insights into the Regulatory Mechanism of the Response Regulator RocR from Pseudomonas aeruginosa in Cyclic Di-GMP Signaling by Chen, Ming Wei, Kotaka, Masayo, Vonrhein, Clemens, Bricogne, Gérard, Rao, Feng, Chuah, Mary Lay Cheng, Svergun, Dmitri, Schneider, Gunter, Liang, Zhao-Xun, Lescar, Julien

“…The nucleotide messenger cyclic di-GMP (c-di-GMP) plays a central role in the regulation of motility, virulence, and biofilm formation in many pathogenic…”
Get full text

Structural basis of FliG–FliM interaction in Helicobacter pylori by Lam, Kwok‐Ho, Lam, Wendy Wai Ling, Wong, Jase Yan‐Kit, Chan, Ling‐Chim, Kotaka, Masayo, Ling, Thomas Kin‐Wah, Jin, Dong‐Yan, Ottemann, Karen M., Au, Shannon Wing‐Ngor

“…Summary FliG and FliM are switch proteins that regulate the rotation and switching of the flagellar motor. Several assembly models for FliG and FliM have…”
Get full text

Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase by Gover, Sheila, Kotaka, Masayo, Au, Shannon W. N., Lam, Veronica M. S., Vandeputte-Rutten, Lucy, Adams, Margaret J.

“…Human glucose‐6‐phosphate dehydrogenase (G6PD) is NADP+‐dependent and catalyses the first and rate‐limiting step of the pentose phosphate shunt. Binary…”
Get full text

Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis by Kotaka, Masayo, Kong, Rong, Qureshi, Insaf, Ho, Qin Shi, Sun, Huihua, Liew, Chong Wai, Goh, Lan Pei, Cheung, Peter, Mu, Yuguang, Lescar, Julien, Liang, Zhao-Xun

“…The biosynthesis of the enediyne moiety of the antitumor natural product calicheamicin involves an iterative polyketide synthase (CalE8) and other ancillary…”
Get full text

GTP Cyclohydrolase II Structure and Mechanism by Ren, Jingshan, Kotaka, Masayo, Lockyer, Michael, Lamb, Heather K., Hawkins, Alastair R., Stammers, David K.

“…GTP cyclohydrolase II converts GTP to 2,5-diamino-6-β-ribosyl-4(3H)-pyrimidinone 5′-phosphate, formate and pyrophosphate, the first step in riboflavin…”
Get full text

C-Terminal Segment of the Cysteine-Rich Interdomain of Plasmodium falciparum Erythrocyte Membrane Protein 1 Determines CD36 Binding and Elicits Antibodies That Inhibit Adhesion of Parasite-Infected Erythrocytes by Mo, Min, Lee, Hooi Chen, Kotaka, Masayo, Niang, Makhtar, Gao, Xiaohong, Iyer, Jayasree Kaveri, Lescar, Julien, Preiser, Peter

“…Attachment of erythrocytes infected by Plasmodium falciparum to receptors of the microvasculature is a major contributor to the pathology and morbidity…”
Get full text

Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics by Yoon, Ho Sup, Alag, Reema, Kang, Congbao, Ye, Hong, Kotaka, Masayo, Qureshi, Insaf A, Bharatham, Nagakumar, Shin, Joon, Bozdech, Zbynek, Preiser, Peter, Lescar, Julien

“…Clinical background The immunosuppressive drug FK506 reveals an antimalarial activity. The mechanism of the drug action involves the molecular interaction with…”
Get full text

Crystal structures of human dihydroxyacetone kinase by Kwok, Jane, Kotaka, Masayo

“…Abstract only Dihydroxyacetone (Dha), also known as glycerone, is a metabolically active carbohydrate. Dha kinase (DAK) is highly conserved enzyme that…”
Get full text

Structural studies of Plasmodium falciparum GTP:AMP phosphotransferase by Ko, Reamonn, Kotaka, Masayo

“…Abstract only Malaria is a global health concern accounting for approximately 219 million cases and an estimated 660 000 deaths in 2010[1]. The most fatal…”
Get full text

Insights from the Structure of an Active Form of IBacillus thuringiensis/I Cry5B by Li, Jiaxin, Wang, Lin, Kotaka, Masayo, Lee, Marianne M, Chan, Michael K

“…The crystal protein Cry5B, a pore-forming protein produced by the soil bacterium Bacillus thuringiensis, has been demonstrated to have excellent anthelmintic…”
Get full text

Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications by Luo, Dahai, Wei, Na, Doan, Danny N., Paradkar, Prasad N., Chong, Yuwen, Davidson, Andrew D., Kotaka, Masayo, Lescar, Julien, Vasudevan, Subhash G.

“…The dengue virus (DENV) NS3 protein is essential for viral polyprotein processing and RNA replication. It contains an N-terminal serine protease region…”
Get full text

Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1 by Lee, Simon Ming Yuen, Li, Hoi Yeung, Ng, Enders Kai On, Or, Simon Man Wai, Chan, Kwok Keung, Kotaka, Masayo, Chim, Stephen Sui Chung, Tsui, Stephen Kwok Wing, Waye, Mary Miu Yee, Fung, Kwok Pui, Lee, Cheuk Yu

“…We have amplified and sequenced a novel, alternatively spliced variant of a human gene coding for the f our-and-a- h alf L IM domain protein 1 (FHL1). This…”
Get full text

Cutting edge: granulocyte-macrophage colony-stimulating factor is the major CD8+ T cell-derived licensing factor for dendritic cell activation by Min, Lin, Mohammad Isa, Siti Aminah Bte, Shuai, Wang, Piang, Cher Boon, Nih, Fam Wee, Kotaka, Masayo, Ruedl, Christiane

“…During priming, CD8(+) T lymphocytes can induce robust maturation of dendritic cells (DCs) in a CD40-independent manner by secreting licensing factor(s). In…”
Get full text

Porcine CD 38 exhibits prominent secondary NAD + cyclase activity by Ting, Kai Yiu, Leung, Christina F. P., Graeff, Richard M., Lee, Hon Cheung, Hao, Quan, Kotaka, Masayo

“…Cyclic ADP‐ribose (cADPR) mobilizes intracellular Ca 2+ stores and activates Ca 2+ influx to regulate a wide range of physiological processes. It is one of the…”
Get full text

Porcine CD38 exhibits prominent secondary NAD+ cyclase activity by Ting, Kai Yiu, Leung, Christina F. P., Graeff, Richard M., Lee, Hon Cheung, Hao, Quan, Kotaka, Masayo

“…Cyclic ADP‐ribose (cADPR) mobilizes intracellular Ca2+ stores and activates Ca2+ influx to regulate a wide range of physiological processes. It is one of the…”
Get full text