Search Results - "KOTA, Poojitha"

High prevalence of GPRC5A germline mutations in BRCA1‐mutant breast cancer patients by Sokolenko, Anna P., Bulanova, Daria R., Iyevleva, Aglaya G., Aleksakhina, Svetlana N., Preobrazhenskaya, Elena V., Ivantsov, Alexandr O., Kuligina, Ekatherina Sh, Mitiushkina, Natalia V., Suspitsin, Evgeny N., Yanus, Grigoriy A., Zaitseva, Olga A., Yatsuk, Olga S., Togo, Alexandr V., Kota, Poojitha, Dixon, J. Michael, Larionov, Alexey A., Kuznetsov, Sergey G., Imyanitov, Evgeny N.

“…In a search for new breast cancer (BC) predisposing genes, we performed a whole exome sequencing analysis using six patient samples of familial BC and…”
Get full text

High prevalence of GPRC5A germline mutations in BRCA1 -mutant breast cancer patients: GPRC5A as a modifier of BRCA1 penetrance by Sokolenko, Anna P., Bulanova, Daria R., Iyevleva, Aglaya G., Aleksakhina, Svetlana N., Preobrazhenskaya, Elena V., Ivantsov, Alexandr O., Kuligina, Ekatherina Sh, Mitiushkina, Natalia V., Suspitsin, Evgeny N., Yanus, Grigoriy A., Zaitseva, Olga A., Yatsuk, Olga S., Togo, Alexandr V., Kota, Poojitha, Dixon, J. Michael, Larionov, Alexey A., Kuznetsov, Sergey G., Imyanitov, Evgeny N.

Get full text

High-Throughput Ex Vivo Drug Sensitivity and Resistance Testing (DSRT) Integrated with Deep Genomic and Molecular Profiling Reveal New Therapy Options with Targeted Drugs in Subgroups of Relapsed Chemorefractory AML by Heckman, Caroline A, Kontro, Mika, Pemovska, Tea, Eldfors, Samuli, Edgren, Henrik, Kulesskiy, Evgeny, Majumder, Muntasir Mamun, Karjalainen, Riikka, Yadav, Bhagwan, Szwajda, Agnieszka, Venkata, Naga Poojitha Kota, Murumägi, Astrid, Malani, Disha, Parsons, Alun, Hintsanen, Petteri, Almusa, Henrikki, Martí, Jesús María López, Ellonen, Pekka, Mattila, Pirkko, Lepistö, Maija, Lagström, Sonja, Suvela, Minna, Mustjoki, Satu, Saarela, Janna, Aittokallio, Tero, Kallioniemi, Olli, Wennerberg, Krister, Porkka, Kimmo

“…Abstract 288 Recent genomic analyses of acute myeloid leukemia (AML) patients have provided new information on mutations contributing to the disease onset and…”
Get full text

Abstract 4580: Personalized treatment selection for therapy-resistant AML by integrating ex-vivo drug sensitivity and resistance testing (DSRT) as well as serial genomic, transcriptomic and phosphoproteomic profiling by Venkata, Naga Poojitha Kota, Kontro, Mika, Edgren, Henrik, Eldfors, Samuli, Pemovska, Tea, Kulesskiy, Evgeny, Majumder, Muntasir Mamun, Murumägi, Astrid, Nicorici, Daniel, Almusa, Henrikki, Mattila, Pirkko, Ellonen, Pekka, Lepistö, Maija, Mpindi, John Patrick, Karjalainen, Riikka, Parsons, Alun, Knowles, Jonathan K.C, Saarela, Janna, Wolf, Maija, Wennerberg, Krister, Heckman, Caroline A., Porkka, Kimmo, Kallioniemi, Olli

“…Abstract Samples from recurrent, treatment-refractory cancers are rarely available, but would be valuable in understanding the molecular drivers of drug…”
Get full text

Abstract 895: Quantitative drug sensitivity and resistance testing (DSRT) of primary ex vivo AML blasts highlights mTOR and MEK as potential key molecular driver signals of therapeutic significance by Pemovska, Tea, Kylesskiy, Evgeny, Kontro, Mika, Szwajda, Agnieszka, Karjalainen, Riikka, Majumder, Muntasir M., Malani, Disha, Bespalov, Maxim M., Eldfors, Samuli, Elonen, Erkki, Knowles, Jonathan, Murumägi, Astrid, Mpindi, John P., Edgren, Henrik, Venkata, Naga Poojitha Kota, Turunen, Laura, Mustjoki, Satu, Wolf, Maija, Yadav, Bhagwan, Aittokallio, Tero, Heckman, Caroline A., Porkka, Kimmo, Kallioniemi, Olli, Wennerberg, Krister

“…Abstract Identification of signaling pathways that are required for the growth and differentiation block of cells from adult acute myeloid leukemia (AML) is…”
Get full text

Abstract 5067: Exome sequencing reveals both DNA sequence and copy number changes in AML: Potential driver changes and mechanisms of drug resistance revealed from serial samples from the same patients by Karjalainen, Riikka, Eldfors, Samuli, Edgren, Henrik, Venkata, Naga Poojitha Kota, Kontro, Mika, Majumder, Muntasir Mamun, Murumägi, Astrid, Parsons, Alun, Almusa, Henrikki, Ellonen, Pekka, Lepistö, Maija, Mattila, Pirkko, Hannula, Sari, Lagström, Sonja, Suvela, Minna, Wolf, Maija, Wennerberg, Krister, Knowles, Jonathan KC, Mustjoki, Satu, Saarela, Janna, Porkka, Kimmo, Kallioniemi, Olli, Heckman, Caroline A.

“…Abstract Despite significant advances in characterizing the molecular genetics of AML, the clonal evolution of leukemic cells and the dynamic impact of genomic…”
Get full text

Abstract 3188: Development of a cancer pharmacopeia-wide ex-vivo drug sensitivity and resistance testing (DSRT) platform for AML: Towards individually optimized therapy and improved understanding of drug resistance patterns by Malani, Disha, Pemovska, Tea, Kontro, Mika, Murumägi, Astrid, Kulesskiy, Evgeny, Yadav, Bhagwan, Bespalov, Maxim, Eldfors, Samuli, Elonen, Erkki, Karjalainen, Riikka, Knowles, Jonathan KC, Majumder, Muntasir Mamun, Mpindi, John Patrick, Edgren, Henrik, Szwajda, Agnieszka, Venkata, Naga Poojitha Kota, Turunen, Laura, Mustjoki, Satu, Wolf, Maija, Aittokallio, Tero, Heckman, Caroline A., Porkka, Kimmo, Wennerberg, Krister, Kallioniemi, Olli

“…Abstract In order to discover unexpected anti-cancer efficacies of approved and emerging drugs, we established a diagnostic ex vivo drug sensitivity and…”
Get full text

Enhanced Malware Detection using Convolutional Neural Network with Robust Ensemble Algorithm-"LIGHTGBM" by Kanumalli, Satya Sandeep, Dalavayi, Neha, Veernapu, Varsha, Kota, Poojitha, Katari, Ratna Priya

“…This In the past few years use of the Internet to transfer data has increased rapidly. It is becoming the target of malware that exploits the vulnerabilities…”
Get full text

High prevalence of GPRC5A germline mutations in BRCA1-mutant breast cancer patients by SOKOLENKO, Anna P, BULANOVA, Daria R, ZAITSEVA, Olga A, YATSUK, Olga S, TOGO, Alexandr V, KOTA, Poojitha, DIXON, J. Michael, LARIONOV, Alexey A, KUZNETSOV, Sergey G, IMYANITOV, Evgeny N, IYEVLEVA, Aglaya G, ALEKSAKHINA, Svetlana N, PREOBRAZHENSKAYA, Elena V, IVANTSOV, Alexandr O, KULIGINA, Ekatherina Sh, MITIUSHKINA, Natalia V, SUSPITSIN, Evgeny N, YANUS, Grigoriy A

Get full text

Abstract 65: Comprehensive ex vivo drug sensitivity testing combined with in depth molecular profiling of AML patients cells provides individualized treatment strategies and reveals mechanisms of drug resistance by Wennerberg, Krister, Pemovska, Tea, Kontro, Mika, Yadav, Bhagwan, Kulesskiy, Evgeny, Edgren, Henrik, Eldfors, Samuli, Karjalainen, Riikka, Kota Venkata, Naga Poojitha, Lehto, Anna, Majumder, Muntasir Mamun, Malani, Disha, Murumägi, Astrid, Turunen, Laura, Knowles, Jonathan, Aittokallio, Tero, Heckman, Caroline, Porkka, Kimmo, Kallioniemi, Olli

“…Abstract Acute myeloid leukemia (AML) is an aggressive, heterogeneous disease with few options for targeted therapy. Here, we describe a novel translational…”
Get full text