A possible mosaic form of delayed centromere separation and aneuploidy

A possible mosaic form of delayed centromere separation and aneuploidy

On average, a "normal" centromere separation sequence was seen in 3 neonates with trisomy 18 and in their parents. When evaluating individual mitoses, unusually late separating chromosomes 18 were found in a few cells of one of the parents in each family. A possible germline mosaicism of d...

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Bibliographic Details
Published in:Human genetics Vol. 88; no. 4; pp. 477 - 478
Main Authors: MEHES, K, KOSZTALANYI, G
Format: Journal Article
Language:English
Published: Heidelberg Springer 01-02-1992
Berlin
New York, NY
Subjects:
Aneuploidy
Biological and medical sciences
Centromere - physiology
centromeres
chromosome 18
Chromosome aberrations
Chromosome Banding
Chromosomes, Human, Pair 18
Female
Humans
Infant, Newborn
Karyotyping
Male
Medical genetics
Medical sciences
mitosis
Mosaicism
Reference Values
Trisomy
Chromosomal aberration
Human
Trisomy
Separation
Centromere
E18-Chromosome
Family study
Germ line
Aneuploidy
Mosaicism
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Summary:On average, a "normal" centromere separation sequence was seen in 3 neonates with trisomy 18 and in their parents. When evaluating individual mitoses, unusually late separating chromosomes 18 were found in a few cells of one of the parents in each family. A possible germline mosaicism of delayed separation in the parent may account for trisomy in the offspring.
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ISSN:0340-6717
1432-1203
DOI:10.1007/BF00215686