Search Results - "KOSUTOVA, P."

Vagal cardiac control in rats with LPS-induced lung injury by Zila, I., Kolomaznik, M., Mikolka, P., Kosutova, P., Czippelova, B., Javorka, M., Calkovska, A.

“…Heart rate variability (HRV) as an index of cardiac autonomic control in acute lung injury (ALI) has been evaluated in anaesthetized rats intratracheally…”
Get full text

Reduction of lung inflammation, oxidative stress and apoptosis by the PDE4 inhibitor roflumilast in experimental model of acute lung injury by Kosutova, P, Mikolka, P, Kolomaznik, M, Balentova, S, Adamkov, M, Calkovska, A, Mokra, D

“…Damage of alveolar-capillary barrier, inflammation, oxidative injury, and lung cell apoptosis represent the key features of acute lung injury (ALI). This study…”
Get full text

Effect of Different Dosages of Dexamethasone Therapy on Lung Function and Inflammation in an Early Phase of Acute Respiratory Distress Syndrome Model by MIKOLKA, P., KOSUTOVA, P., KOLOMAZNIK, M., TOPERCEROVA, J., KOPINCOVA, J., CALKOVSKA, A., MOKRA, D.

“…Inflammation associated with acute respiratory distress syndrome (ARDS) can damage the alveolar epithelium and surfactant and worsen the respiratory failure…”
Get full text

Effects of Nitric Oxide Donor on the Lung Functions in a Saline Lavage-Induced Model of ARDS by KOSUTOVA, P., MIKOLKA, P., BALENTOVA, S., ADAMKOV, M., MOKRA, D.

“…Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia, neutrophil-mediated inflammation, and lung edema formation. Whereas lung damage…”
Get full text

Lung inflammatory and oxidative alterations after exogenous surfactant therapy fortified with budesonide in rabbit model of meconium aspiration syndrome by Mikolka, P, Kopincová, J, Košútová, P, Čierny, D, Čalkovská, A, Mokrá, D

“…Meconium aspiration syndrome (MAS) triggers inflammatory and oxidative pathways which can inactivate both pulmonary surfactant and therapeutically given…”
Get full text

Effects of roflumilast, a phosphodiesterase-4 inhibitor, on the lung functions in a saline lavage-induced model of acute lung injury by Kosutova, P, Mikolka, P, Kolomaznik, M, Rezakova, S, Calkovska, A, Mokra, D

“…Acute lung injury (ALI) is associated with deterioration of alveolar-capillary lining and transmigration and activation of inflammatory cells. Whereas a…”
Get full text

Effects of budesonide on the lung functions, inflammation and apoptosis in a saline-lavage model of acute lung injury by Mokra, D, Kosutova, P, Balentova, S, Adamkov, M, Mikolka, P, Mokry, J, Antosova, M, Calkovska, A

“…Diffuse alveolar injury, edema, and inflammation are fundamental signs of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Whereas the…”
Get more information

Experimental Models of Acute Lung Injury: their Advantages and Limitations by Mokra, D, Mikolka, P, Kosutova, P, Calkovska, A.

“…Acute damage to the lung may originate from various direct and indirect reasons. Direct lung injury may be caused by pneumonia, near-drowning, aspiration,…”
Get full text

Effects of S-Nitroso-N-Acetyl-Penicillamine (SNAP) on Inflammation, Lung Tissue Apoptosis and iNOS Activity in a Rabbit Model of Acute Lung Injury by Kosutova, P, Mikolka, P, Kolomaznik, M, Balentova, S, Calkovska, A, Mokra, D

“…Acute lung injury is characterized by lung edema, surfactant dysfunction, and inflammation. The main goal of our study was to evaluate effects of…”
Get more information

Effects of surfactant/budesonide therapy on oxidative modifications in the lung in experimental meconium-induced lung injury by Mikolka, P, Kopincova, J, Tomcikova Mikusiakova, L, Kosutova, P, Antosova, M, Calkovska, A, Mokra, D

“…Meconium aspiration syndrome (MAS) is a serious condition, which can be treated with exogenous surfactant and mechanical ventilation. However, meconium-induced…”
Get more information

Selective Inhibition of NF-κB and Surfactant Therapy in Experimental Meconium-Induced Lung Injury by KOPINCOVA, J., MIKOLKA, P., KOLOMAZNIK, M., KOSUTOVA, P., CALKOVSKA, A., MOKRA, D.

“…Meconium aspiration syndrome (MAS) in newborns is characterized mainly by respiratory failure due to surfactant dysfunction and inflammation. Previous…”
Get full text

Intravenous dexamethasone attenuated inflammation and influenced apoptosis of lung cells in an experimental model of acute lung injury by Kosutova, P, Mikolka, P, Balentova, S, Adamkov, M, Kolomaznik, M, Calkovska, A, Mokra, D

“…Acute lung injury (ALI) is characterized by diffuse alveolar damage, inflammation, and transmigration and activation of inflammatory cells. This study…”
Get full text

Nasal nitric oxide in healthy adults - reference values and affecting factors by Antosova, M, Mokra, D, Tonhajzerova, I, Mikolka, P, Kosutova, P, Mestanik, M, Pepucha, L, Plevkova, J, Buday, T, Calkovsky, V, Bencova, A

“…Nitric oxide (NO) is an important endogenous mediator with significant role in the respiratory system. Many endogenous and exogenous factors influence the…”
Get full text

High-Frequency Jet Ventilation against Small-Volume Conventional Mechanical Ventilation in the Rabbit Models of Neonatal Acute Lung Injury by Mokra, D, Mikusiakova, L Tomcikova, Mikolka, P, Kosutova, P, Jurcek, M, Kolomaznik, M, Calkovska, A

“…Patients with acute lung injury are ventilated by conventional mechanical ventilation (CMV) rather than high-frequency jet ventilation (HFJV). This study…”
Get more information

The effect of selective antagonist of H4 receptor JNJ7777120 on nasal symptoms, cough, airway reactivity and inflammation in guinea pigs by Kovacova-Hanuskova, E, Gavliakova, S, Buday, T, Kosutova, P, Mokra, D, Urbanova-Fulmekova, A, Mokry, J, Plevkova, J

“…Highlights • Allergic rhinitis induced in experimental conditions up-regulates coughing and airway responsiveness via inflammation and neural mechanisms. •…”
Get full text

Effects on Lung Function of Small-Volume Conventional Ventilation and High-Frequency Oscillatory Ventilation in a Model of Meconium Aspiration Syndrome by Mikusiakova, L Tomcikova, Pistekova, H, Kosutova, P, Mikolka, P, Calkovska, A, Mokra, D

“…For treatment of severe neonatal meconium aspiration syndrome (MAS), lung-protective mechanical ventilation is essential. This study compared short-term…”
Get more information

Antiinflammatory Effect of N-Acetylcysteine Combined with Exogenous Surfactant in Meconium-Induced Lung Injury by Mikolka, P, Kopincova, J, Mikusiakova, L Tomcikova, Kosutova, P, Calkovska, A, Mokra, D

“…Neonatal meconium aspiration syndrome (MAS) can be treated by exogenous surfactant (S). However, aspirated meconium initiates local inflammation and oxidation…”
Get more information

Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs by Mokrý, J, Urbanová, A, Medvedová, I, Kertys, M, Mikolka, P, Kosutová, P, Mokrá, D

“…Phosphodiesterases (PDEs) are enzymes involved in the degradation of cAMP and cGMP. Selective PDE4 inhibitors (e.g., roflumilast) are effective in therapy of…”
Get more information

Bronchodilator and Anti-Inflammatory Action of Theophylline in a Model of Ovalbumin-Induced Allergic Inflammation by Urbanova, A, Kertys, M, Simekova, M, Mikolka, P, Kosutova, P, Mokra, D, Mokry, J

“…Phosphodiesterases (PDEs) represent a super-family of 11 enzymes hydrolyzing cyclic nucleotides into inactive 5' monophosphates. Inhibition of PDEs leads to a…”
Get more information

Aspiration syndromes and associated lung injury: incidence, pathophysiology and management by Košutova, P, Mikolka, P

“…Aspiration is a common condition affecting healthy or sick patients which could create an acute or chronic inflammatory reaction in the lungs. Aspiration…”
Get full text