Search Results - "KOSTNER, Karam M"

Lipoprotein (a): a historical appraisal by Kostner, Karam M., Kostner, Gert M.

“…Initially, lipoprotein (a) [Lp(a)] was believed to be a genetic variant of lipoprotein (Lp)-B. Because its lipid moiety is almost identical to LDL, Lp(a) has…”
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Lp(a) and the Risk for Cardiovascular Disease: Focus on the Lp(a) Paradox in Diabetes Mellitus by Kostner, Karam M, Kostner, Gerhard M

“…Lipoprotein(a) (Lp(a)) is one of the strongest causal risk factors of atherosclerotic disease. It is rich in cholesteryl ester and composed of apolipoprotein B…”
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Relation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to Insulin Resistance and Inflammation by Dahiya, Rachana, MBBS, Shultz, Sarah P., PhD, Dahiya, Arun, MBBS, Fu, Jinlin, PhD, Flatley, Christopher, MClinEpid, Duncan, Danusia, BSc, Cardinal, John, PhD, Kostner, Karam M., PhD, Byrne, Nuala M., PhD, Hills, Andrew P., PhD, Harris, Mark, MD, Conwell, Louise S., PhD, Leong, Gary M., PhD

“…Insulin resistance (IR) and inflammation are associated with an increased risk of cardiovascular disease and may contribute to obesity cardiomyopathy. The…”
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Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice by Chennamsetty, Indumathi, Kostner, Karam M., Claudel, Thierry, Vinod, Manjula, Frank, Sasa, Weiss, Thomas S., Trauner, Michael, Kostner, Gerhard M.

“…Elevated plasma lipoprotein(a) (LPA) levels are recognized as an independent risk factor for cardiovascular diseases. Our knowledge on LPA metabolism is…”
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Corrigendum to Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: An Australian perspective [American Journal of Preventive Cardiology 6 (2021) 100151] by Watts, Gerald F., Sullivan, David R., Hare, David L., Kostner, Karam M., Horton, Ari E., Bell, Damon A., Brett, Tom, Trent, Ronald J., Poplawski, Nicola K., Martin, Andrew C., Srinivasan, Shubha, Justo, Robert N., Chow, Clara K., Pang, Jing

“…[This corrects the article DOI: 10.1016/j.ajpc.2021.100151.]…”
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The 10 essential questions regarding lipoprotein(a) by Kostner, Karam M, Kostner, Gerhard M

“…Lp(a) is one of the most atherogenic lipoproteins, and significant progress has been made to understand its pathophysiology over the last 20 years. There are…”
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Is Lp(a) ready for prime time use in the clinic? A pros-and-cons debate by Kostner, Karam M., Kostner, Gert M., Wierzbicki, Anthony S.

“…Lipoprotein (a) (Lp(a)) is a cholesterol-rich lipoprotein known since 1963. In spite of extensive research on Lp(a), there are still numerous gaps in our…”
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When should we measure lipoprotein (a)? by Kostner, Karam M, März, Winfried, Kostner, Gerhard M

“…Recently published epidemiological and genetic studies strongly suggest a causal relationship of elevated concentrations of lipoprotein (a) [Lp(a)] with…”
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Familial Hypercholesterolaemia in 2020: A Leading Tier 1 Genomic Application by Pang, Jing, Sullivan, David R., Brett, Tom, Kostner, Karam M., Hare, David L., Watts, Gerald F.

“…Familial hypercholesterolaemia (FH) is caused by a major genetic defect in the low-density lipoprotein (LDL) clearance pathway. Characterised by…”
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Continuation of Statin Therapy in Patients with Presumed Infection: A Randomized Controlled Trial by KRUGER, Peter S, HARWARD, Meg L, JONES, Mark A, JOYCE, Christopher J, KOSTNER, Karam M, ROBERTS, Michael S, VENKATESH, Bala

“…In patients on prior statin therapy who are hospitalized for acute infections, current literature is unclear on whether statins should be continued during…”
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Farnesoid X receptor represses hepatic human APOA gene expression by Chennamsetty, Indumathi, Claudel, Thierry, Kostner, Karam M, Baghdasaryan, Anna, Kratky, Dagmar, Levak-Frank, Sanja, Frank, Sasa, Gonzalez, Frank J, Trauner, Michael, Kostner, Gert M

“…High plasma concentrations of lipoprotein(a) [Lp(a), which is encoded by the APOA gene] increase an individual's risk of developing diseases, such as coronary…”
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Integrated Guidance for Enhancing the Care of Familial Hypercholesterolaemia in Australia by Watts, Gerald F., Sullivan, David R., Hare, David L., Kostner, Karam M., Horton, Ari E., Bell, Damon A., Brett, Tom, Trent, Ronald J., Poplawski, Nicola K., Martin, Andrew C., Srinivasan, Shubha, Justo, Robert N., Chow, Clara K., Pang, Jing, Ademi, Zanfina, Ardill, Justin J., Barnett, Wendy, Bates, Timothy R., Beilin, Lawrence J., Bishop, Warrick, Black, J. Andrew, Brett, Peter, Brown, Alex, Burnett, John R., Bursill, Christina A., Colley, Alison, Clifton, Peter M., Ekinci, Elif I., Elias, Luke, Figtree, Gemma A., Forge, Brett H., Garton-Smith, Jacquie, Graham, Dorothy F., Hamilton-Craig, Ian, Hamilton-Craig, Christian R., Heal, Clare, Hespe, Charlotte M., Hooper, Amanda J., Howes, Laurence G., Ingles, Jodie, Irvin, John, Janus, Edward D., Kangaharan, Nadarajah, Keech, Anthony C., Kirke, Andrew B., Kritharides, Leonard, Kyle, Campbell V., Lacaze, Paul, Lambert, Kirsten, Li, Stephen C.H., Malan, Wynand, Maticevic, Stjepana, McQuillan, Brendan M., Mirzaee, Sam, Mori, Trevor A., Morton, Allison C., Colquhoun, David M., Moullin, Joanna C., Nestel, Paul J., Nowak, Kristen J., O'Brien, Richard C., Pachter, Nicholas, Page, Michael M., Pedrotti, Annette, Psaltis, Peter J., Radford, Jan, Reid, Nicola J., Robertson, Elizabeth N., Ryan, Jacqueline D.M., Sarkies, Mitchell N., Schultz, Carl J., Scott, Russell S., Semsarian, Christopher, Simons, Leon A., Spinks, Catherine, Tonkin, Andrew M., van Bockxmeer, Frank, Waddell-Smith, Kathryn E., Ward, Natalie C., White, Harvey D., Wilson, Andrew M., Winship, Ingrid, Woodward, Ann Marie, Nicholls, Stephen J.

“…Familial hypercholesterolaemia (FH) is a dominant and highly penetrant monogenic disorder present from birth that markedly elevates plasma low-density…”
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FGF19 Signaling Cascade Suppresses APOA Gene Expression by Chennamsetty, Indumathi, Claudel, Thierry, Kostner, Karam M, Trauner, Michael, Kostner, Gert M

“…OBJECTIVE—Lipoprotein(a) is a highly atherogenic lipoprotein, whose metabolism is poorly understood. Currently no safe drugs exists that lower elevated plasma…”
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Australian Atherosclerosis Society Position Statement on Lipoprotein(a): Clinical and Implementation Recommendations by Ward, Natalie C., Watts, Gerald F., Bishop, Warrick, Colquhoun, David, Hamilton-Craig, Christian, Hare, David L., Kangaharan, Nadarajah, Kostner, Karam M., Kritharides, Leonard, O’Brien, Richard, Mori, Trevor A., Nestel, Paul J., Nicholls, Stephen J., Psaltis, Peter J., Raffoul, Natalie, White, Harvey D., Sullivan, David R.

“…This position statement provides guidance to cardiologists and related specialists on the management of adult patients with elevated lipoprotein(a) [Lp(a)]…”
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Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians by Watts, Gerald F., Sullivan, David R., Hare, David L., Kostner, Karam M., Horton, Ari E., Bell, Damon A., Brett, Tom, Trent, Ronald J., Poplawski, Nicola K., Martin, Andrew C., Srinivasan, Shubha, Justo, Robert N., Chow, Clara K., Pang, Jing

“…Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease. New clinical practice recommendations…”
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Gaps in the Care of Familial Hypercholesterolaemia in Australia: First Report From the National Registry by Pang, Jing, Sullivan, David R., Hare, David L., Colquhoun, David M., Bates, Timothy R., Ryan, Jacqueline D.M., Bishop, Warrick, Burnett, John R., Bell, Damon A., Simons, Leon A., Mirzaee, Sam, Kostner, Karam M., Nestel, Paul J., Wilson, Andrew M., O’Brien, Richard C., Janus, Edward D., Clifton, Peter M., Ardill, Justin J., Chan, Dick C., van Bockxmeer, Frank, Watts, Gerald F.

“…Familial hypercholesterolaemia (FH) is under-diagnosed and under-treated worldwide, including Australia. National registries play a key role in identifying…”
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Molecular, Population, and Clinical Aspects of Lipoprotein(a): A Bridge Too Far? by Ward, Natalie C, Kostner, Karam M, Sullivan, David R, Nestel, Paul, Watts, Gerald F

“…There is now significant evidence to support an independent causal role for lipoprotein(a) (Lp(a)) as a risk factor for atherosclerotic cardiovascular disease…”
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Statin therapy for hypertrophic cardiomyopathy: too good to be true? by Kostner, Karam M.

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Status of PCSK9 Monoclonal Antibodies in Australia by Scherer, Daniel J, Nelson, Adam J, O’Brien, Richard, Kostner, Karam M., Hare, David L., Colquhoun, David M., Barter, Philip J., Aylward, Philip, Nicholls, Stephen J., Watts, Gerald F.

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAb) have progressed from showing marked low density lipoprotein cholesterol…”
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Acute elevation of lipids does not alter exercise hemodynamics in healthy men: A randomized controlled study by Sharman, James E, Holland, David J, Leano, Rodel, Kostner, Karam M

“…Abstract Objective Exaggerated exercise blood pressure (BP) predicts mortality. Some studies suggest this could be explained by chronic hyperlipidemia, but…”
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