Search Results - "KOSTNER, Gert M"

Lipoprotein (a): a historical appraisal by Kostner, Karam M., Kostner, Gert M.

“…Initially, lipoprotein (a) [Lp(a)] was believed to be a genetic variant of lipoprotein (Lp)-B. Because its lipid moiety is almost identical to LDL, Lp(a) has…”
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Is Lp(a) ready for prime time use in the clinic? A pros-and-cons debate by Kostner, Karam M., Kostner, Gert M., Wierzbicki, Anthony S.

“…Lipoprotein (a) (Lp(a)) is a cholesterol-rich lipoprotein known since 1963. In spite of extensive research on Lp(a), there are still numerous gaps in our…”
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New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk by Klose, Gerald, Beil, Frank Ulrich, Dieplinger, Hans, von Eckardstein, Arnold, Föger, Bernhard, Gouni-Berthold, Ioanna, Heigl, Franz, Koenig, Wolfgang, Kostner, Gert M., Landmesser, Ulf, Laufs, Ulrich, Leistikow, Frank, März, Winfried, Noll, Georg, Parhofer, Klaus G., Paulweber, Bernhard, Riesen, Walter F., Schaefer, Jürgen R., Steinhagen-Thiessen, Elisabeth, Steinmetz, Armin, Toplak, Hermann, Wanner, Christoph, Windler, Eberhard

“…Summary After the publication of the new guidelines of the European Society of Cardiology and the European Atherosclerosis Society for the prevention and…”
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Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity by Strauss, Juliane G, Zimmermann, Robert, Hrzenjak, Andelko, Zhou, Yonggang, Kratky, Dagmar, Levak-Frank, Sanja, Kostner, Gert M, Zechner, Rudolf, Frank, Sasa

“…Endothelial cell-derived lipase (EDL) is a new member of the lipase gene family with high sequence homology with lipoprotein lipase (LPL). EDL is a…”
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Farnesoid X receptor represses hepatic human APOA gene expression by Chennamsetty, Indumathi, Claudel, Thierry, Kostner, Karam M, Baghdasaryan, Anna, Kratky, Dagmar, Levak-Frank, Sanja, Frank, Sasa, Gonzalez, Frank J, Trauner, Michael, Kostner, Gert M

“…High plasma concentrations of lipoprotein(a) [Lp(a), which is encoded by the APOA gene] increase an individual's risk of developing diseases, such as coronary…”
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Galactose-specific asialoglycoprotein receptor is involved in lipoprotein (a) catabolism by Hrzenjak, Andelko, Frank, Sasa, Wo, Xingde, Zhou, Yonggang, Van Berkel, Theo, Kostner, Gert M

“…Lp(a) [lipoprotein (a)] is a highly atherogenic plasma lipoprotein assembled from low-density lipoprotein and the glycoprotein apolipoprotein (a). The rate of…”
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FGF19 Signaling Cascade Suppresses APOA Gene Expression by Chennamsetty, Indumathi, Claudel, Thierry, Kostner, Karam M, Trauner, Michael, Kostner, Gert M

“…OBJECTIVE—Lipoprotein(a) is a highly atherogenic lipoprotein, whose metabolism is poorly understood. Currently no safe drugs exists that lower elevated plasma…”
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Submaximal stimulation of porcine endothelial cells causes focal Ca2+ elevation beneath the cell membrane by Graier, W F, Paltauf-Doburzynska, J, Hill, B J, Fleischhacker, E, Hoebel, B G, Kostner, G M, Sturek, M

“…Endothelial cell activation is correlated with increased cytosolic Ca 2+ concentration, often monitored with cytoplasmic Ca 2+ dyes, such as fura-2 and Calcium…”
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Angiotensinogen Polymorphism M235T, Carotid Atherosclerosis, and Small-Vessel Disease-Related Cerebral Abnormalities by Schmidt, Reinhold, Schmidt, Helena, Fazekas, Franz, Launer, Lenore J, Niederkorn, Kurt, Kapeller, Peter, Lechner, Anita, Kostner, Gert M

“…The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease. We studied the role of this polymorphism as a risk factor…”
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Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis by Wagner, Elke M., Kratky, Dagmar, Haemmerle, Guenter, Hrzenjak, Andelko, Kostner, Gert M., Steyrer, Ernst, Zechner, Rudolf

“…Lipoprotein lipase (LPL) is the only known enzyme in the capillary endothelium of peripheral tissues that hydrolizes plasma triglycerides and provides fatty…”
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Preparation of a stable fresh frozen primary lipoprotein[a] (Lp[a]) standard by Kostner, G M, Ibovnik, A, Holzer, H, Grillhofer, H

“…LP[a] is one of the most atherogenic lipoproteins consisting of an LDL-like core particle and a covalently linked glycoprotein of variable size. Due to its…”
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Factors affecting plasma lipoprotein(a) levels: role of hormones and other nongenetic factors by Kostner, Karam M, Kostner, Gert M

“…Lp(a) appears to be one of the most atherogenic lipoproteins. It consists of an low-density lipoprotein core in addition to a covalently bound glycoprotein,…”
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Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis by Caplice, Noel M., Panetta, Carmelo, Peterson, Timothy E., Kleppe, Laurel S., Mueske, Cheryl S., Kostner, Gert M., Broze, George J., Simari, Robert D.

“…Lipoprotein (a) [Lp(a)] has been associated with both anti-fibrinolytic and atherogenic effects. However, no direct link currently exists between this…”
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Urinary excretion of apolipoprotein(a): relation to other plasma proteins by Kostner, Karam, Spitzauer, Susanne, Rumpold, Helmut, Maurer, Gerald, Knipping, Gabriele, Hrzenjak, Andelko, Frank, Sasa, Kostner, Gert M.

“…The atherogenic lipoprotein Lp(a) consists of an LDL-like core and apo(a), linked to apoB via a thiol bridge. Apo(a) fragments ranging in size from 60 to 220…”
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A Third Major Locus for Autosomal Dominant Hypercholesterolemia Maps to 1p34.1-p32 by Varret, Mathilde, Rabès, Jean-Pierre, Saint-Jore, Bruno, Cenarro, Ana, Marinoni, Jean-Christophe, Civeira, Fernando, Devillers, Martine, Krempf, Michel, Coulon, Monique, Thiart, Rochelle, Kotze, Maritha J., Schmidt, Helena, Buzzi, Jean-Claude, Kostner, Gert M., Bertolini, Stephano, Pocovi, Miguel, Rosa, Alberto, Farnier, Michel, Martinez, Maria, Junien, Claudine, Boileau, Catherine

“…Autosomal dominant hypercholesterolemia (ADH), one of the most frequent hereditary disorders, is characterized by an isolated elevation of LDL particles that…”
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Paraoxonase PON1 polymorphism Leu-Met54 is associated with carotid atherosclerosis : Results of the Austrian stroke prevention study by SCHMIDT, H, SCHMIDT, R, NIEDERKORN, K, GRADERT, A, SCHUMACHER, M, WATZINGER, N, HARTUNG, H.-P, KOSTNER, G. M

“…Genetic polymorphism at the paraoxonase locus is associated with serum concentration and activity of paraoxonase and with increased risk for coronary heart…”
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MRI Cerebral White Matter Lesions and Paraoxonase PON1 Polymorphisms: Three-Year Follow-Up of the Austrian Stroke Prevention Study by Schmidt, Reinhold, Schmidt, Helena, Fazekas, NA, Kapeller, Peter, Roob, Gudrun, Lechner, Anita, Kostner, Gert M, Hartung, Hans-Peter

“…White matter lesions (WMLs) on magnetic resonance imaging (MRI) scans of older persons are thought to be caused by cerebral small-vessel disease. As they…”
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Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: Results of the Austrian Stroke Prevention Study by SCHMIDT, Helena, FAZEKAS, Franz, KOSTNER, Gert M, VAN DUIJN, Cornelia M, SCHMIDT, Reinhold

“…Microangiopathy-related cerebral damage (MARCD) is a common finding in the elderly. It may lead to cognitive impairment and gait disturbances. Arterial…”
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Enhanced Association of Platelet-activating Factor Acetylhydrolase with Lipoprotein (a) in Comparison with Low Density Lipoprotein (∗) by Blencowe, Christopher, Hermetter, Albin, Kostner, Gert M., Deigner, Hans P.

“…Paired samples of human Lipoprotein (a) (Lp(a)) and low density lipoprotein (LDL) were assayed for their platelet-activating factor (PAF) acetylhydrolase…”
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Beta-Fibrinogen Gene Polymorphism (C148 [right arrow] T) Is Associated With Carotid Atherosclerosis: Results of the Austrian Stroke Prevention Study by Schmidt, Helena, Schmidt, Reinhold, Niederkorn, Kurt, Horner, Susanne, Becsagh, Peter, Reinhart, Birgit, Schumacher, Martin, Weinrauch, Viktor, Kostner, Gert M

“…Polymorphisms at the beta-fibrinogen locus have been shown to be associated with plasma concentration of fibrinogen and coronary heart disease. The effect of…”
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