Search Results - "KOSTMAN, Jay"

Listen to Your Heart by Kostman, Jay R

Get full text

Access to Costly New Hepatitis C Drugs: Medicine, Money, and Advocacy by Trooskin, Stacey B., Reynolds, Helen, Kostman, Jay R.

“…Hepatitis C affects >3 million people in the United States, and often leads to end-stage liver disease or death. In 2014, several new drugs to treat hepatitic…”
Get full text

Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV by Giron, Leila B., Palmer, Clovis S., Liu, Qin, Yin, Xiangfan, Papasavvas, Emmanouil, Sharaf, Radwa, Etemad, Behzad, Damra, Mohammad, Goldman, Aaron R., Tang, Hsin-Yao, Johnston, Rowena, Mounzer, Karam, Kostman, Jay R., Tebas, Pablo, Landay, Alan, Montaner, Luis J., Jacobson, Jeffrey M., Li, Jonathan Z., Abdel-Mohsen, Mohamed

“…Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety…”
Get full text

Cloning and Functional Characterization of Novel Human Neutralizing Anti-IFN-α and Anti-IFN-β Antibodies by Papasavvas, Emmanouil, Lu, Lily, Fair, Matthew, Oliva, Isabela, Cassel, Joel, Majumdar, Sonali, Mounzer, Karam, Kostman, Jay R, Tebas, Pablo, Bar-Or, Amit, Muthumani, Kar, Montaner, Luis J

“…Type I IFNs play a pivotal role in immune response modulation, yet dysregulation is implicated in various disorders. Therefore, it is crucial to develop tools…”
Get full text

Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study by Lo Re, 3rd, Vincent, Kallan, Michael J, Tate, Janet P, Localio, A Russell, Lim, Joseph K, Goetz, Matthew Bidwell, Klein, Marina B, Rimland, David, Rodriguez-Barradas, Maria C, Butt, Adeel A, Gibert, Cynthia L, Brown, Sheldon T, Park, Lesley, Dubrow, Robert, Reddy, K Rajender, Kostman, Jay R, Strom, Brian L, Justice, Amy C

“…The incidence and determinants of hepatic decompensation have been incompletely examined among patients co-infected with HIV and hepatitis C virus (HCV) in the…”
Get full text

Disparities in Absolute Denial of Modern Hepatitis C Therapy by Type of Insurance by Lo Re, Vincent, Gowda, Charitha, Urick, Paul N, Halladay, Joshua T, Binkley, Amanda, Carbonari, Dena M, Battista, Kathryn, Peleckis, Cassandra, Gilmore, Jody, Roy, Jason A, Doshi, Jalpa A, Reese, Peter P, Reddy, K. Rajender, Kostman, Jay R

“…Background & Aims The high costs of direct-acting antiviral (DAA) agents to treat chronic hepatitis C virus (HCV) infection have resulted in denials of…”
Get full text

Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration by Azzoni, Livio, Foulkes, Andrea S., Papasavvas, Emmanouil, Mexas, Angela M., Lynn, Kenneth M., Mounzer, Karam, Tebas, Pablo, Jacobson, Jeffrey M., Frank, Ian, Busch, Michael P., Deeks, Steven G., Carrington, Mary, O'Doherty, Una, Kostman, Jay, Montaner, Luis J.

“…Background. Antiretroviral therapy (ART)-mediated immune reconstitution fails to restore the capacity of the immune system to spontaneously control human…”
Get full text

Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint by Giron, Leila B., Papasavvas, Emmanouil, Azzoni, Livio, Yin, Xiangfan, Anzurez, Alitzel, Damra, Mohammad, Mounzer, Karam, Kostman, Jay R., Sanne, Ian, Firnhaber, Cynthia S., Tateno, Hiroaki, Liu, Qin, Montaner, Luis J., Abdel-Mohsen, Mohamed

“…OBJECTIVE:HIV cure research urgently needs to identify pre-analytic treatment interruption (ATI) biomarkers of time-to-viral-rebound and viral setpoint to…”
Get full text

Risk of HCC With Hepatitis B Viremia Among HIV/HBV‐Coinfected Persons in North America by Kim, H. Nina, Newcomb, Craig W., Carbonari, Dena M., Roy, Jason A., Torgersen, Jessie, Althoff, Keri N., Kitahata, Mari M., Reddy, K. Rajender, Lim, Joseph K., Silverberg, Michael J., Mayor, Angel M., Horberg, Michael A., Cachay, Edward R., Kirk, Gregory D., Sun, Jing, Hull, Mark, Gill, M. John, Sterling, Timothy R., Kostman, Jay R., Peters, Marion G., Moore, Richard D., Klein, Marina B., Lo Re, Vincent

“…Background and Aims Chronic HBV is the predominant cause of HCC worldwide. Although HBV coinfection is common in HIV, the determinants of HCC in HIV/HBV…”
Get full text

Susceptibility to 3BNC117 and 10-1074 in ART suppressed chronically infected persons by Tebas, Pablo, Lynn, Kenn, Azzoni, Livio, Cocchella, Giorgio, Papasavvas, Emmanouil, Fair, Matthew, Karanam, Brijesh, Sharma, Paridhima, Reeves, Jacqueline D., Petropoulos, Christos J., Lalley-Chareczko, Linden, Kostman, Jay R., Short, Willian, Mounzer, Karam, Montaner, Luis J.

“…The aim of this study was to assess the susceptibility of HIV to two HIV monoclonal antibodies (bnAbs), 3BNC117 and 10-1074, in individuals with chronically…”
Get full text

Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients by DallaPiazza, Michelle, Amorosa, Valerianna K, Localio, Russell, Kostman, Jay R, Lo Re, 3rd, Vincent

“…HIV-monoinfected patients may be at risk for significant liver fibrosis, but its prevalence and determinants in these patients are unknown. Since…”
Get full text

Comparable HIV suppression by pegylated-IFN-α2a or pegylated-IFN-α2b during a 4-week analytical treatment interruption by Papasavvas, Emmanouil, Azzoni, Livio, Ross, Brian N., Fair, Matthew, Howell, Bonnie J., Hazuda, Daria J., Mounzer, Karam, Kostman, Jay R., Tebas, Pablo, Montaner, Luis J.

“…We report on the post-hoc analysis of three clinical studies (NCT01935089, NCT00594880 and NCT00051818) with chronically HIV-infected, immune-reconstituted…”
Get full text

Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy by Papasavvas, Emmanouil, Azzoni, Livio, Ross, Brian N, Fair, Matthew, Yuan, Zhe, Gyampoh, Kwasi, Mackiewicz, Agnieszka, Sciorillo, Amanda C, Pagliuzza, Amelie, Lada, Steven M, Wu, Guoxin, Goh, Shih Lin, Bahnck-Teets, Carolyn, Holder, Daniel J, Zuck, Paul D, Damra, Mohammad, Lynn, Kenneth M, Tebas, Pablo, Mounzer, Karam, Kostman, Jay R, Abdel-Mohsen, Mohamed, Richman, Douglas, Chomont, Nicolas, Howell, Bonnie J, Montaner, Luis J

“…Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral…”
Get full text

Absolute Insurer Denial of Direct-Acting Antiviral Therapy for Hepatitis C: A National Specialty Pharmacy Cohort Study by Gowda, Charitha, Lott, Stephen, Grigorian, Matthew, Carbonari, Dena M, Saine, M Elle, Trooskin, Stacey, Roy, Jason A, Kostman, Jay R, Urick, Paul, Lo Re, Vincent

“…Abstract Background Despite the availability of new direct-acting antiviral (DAA) regimens, changes in DAA reimbursement criteria, and a public health focus on…”
Get full text

A correlate of HIV-1 control consisting of both innate and adaptive immune parameters best predicts viral load by multivariable analysis in HIV-1 infected viremic controllers and chronically-infected non-controllers by Tomescu, Costin, Liu, Qin, Ross, Brian N, Yin, Xiangfan, Lynn, Kenneth, Mounzer, Karam C, Kostman, Jay R, Montaner, Luis J

“…HIV-1 infected viremic controllers maintain durable viral suppression below 2000 copies viral RNA/ml without anti-retroviral therapy (ART), and the…”
Get full text

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption by Giron, Leila B, Papasavvas, Emmanouil, Yin, Xiangfan, Goldman, Aaron R, Tang, Hsin-Yao, Palmer, Clovis S, Landay, Alan L, Li, Jonathan Z, Koethe, John R, Mounzer, Karam, Kostman, Jay R, Liu, Qin, Montaner, Luis J, Abdel-Mohsen, Mohamed

“…Lipids are biologically active molecules involved in a variety of cellular processes and immunological functions, including inflammation. It was recently shown…”
Get full text

NK Response Correlates with HIV Decrease in Pegylated IFN-α2a-Treated Antiretroviral Therapy-Suppressed Subjects by Papasavvas, Emmanouil, Azzoni, Livio, Kossenkov, Andrew V, Dawany, Noor, Morales, Knashawn H, Fair, Matthew, Ross, Brian N, Lynn, Kenneth, Mackiewicz, Agnieszka, Mounzer, Karam, Tebas, Pablo, Jacobson, Jeffrey M, Kostman, Jay R, Showe, Louise, Montaner, Luis J

“…We previously reported that pegylated IFN-α2a (Peg-IFN-α2a) added to antiretroviral therapy (ART)-suppressed, HIV-infected subjects resulted in plasma HIV…”
Get full text

Safety, Immune, and Antiviral Effects of Pegylated Interferon Alpha 2b Administration in Antiretroviral Therapy-Suppressed Individuals: Results of Pilot Clinical Trial by Papasavvas, Emmanouil, Azzoni, Livio, Pagliuzza, Amélie, Abdel-Mohsen, Mohamed, Ross, Brian N, Fair, Matthew, Howell, Bonnie J, Hazuda, Daria J, Chomont, Nicolas, Li, Qingsheng, Mounzer, Karam, Kostman, Jay R, Tebas, Pablo, Montaner, Luis J

“…In the pilot NCT01935089 trial, we tested whether pegylated interferon alpha2b (Peg-IFN-α2b) with antiretroviral therapy (ART) was safe and could impact HIV…”
Get more information

Analytical antiretroviral therapy interruption does not irreversibly change preinterruption levels of cellular HIV by Papasavvas, Emmanouil, Lada, Steven M, Joseph, Jocelin, Yin, Xiangfan, Liu, Qin, Azzoni, Livio, Mounzer, Karam, Kostman, Jay R, Richman, Douglas, Montaner, Luis J

“…OBJECTIVE:The impact of short-term analytical treatment interruptions (ATI) on the levels of cellular HIV and of residual activation after subsequent…”
Get full text

Hepatitis C virus modulates IgG glycosylation in HIV co-infected antiretroviral therapy suppressed individuals by Giron, Leila B., Azzoni, Livio, Yin, Xiangfan, Lynn, Kenneth M., Ross, Brian N., Fair, Matthew, Damra, Mohammad, Sciorillo, Amanda C., Liu, Qin, Jacobson, Jeffrey M., Mounzer, Karam, Kostman, Jay R., Abdel-Mohsen, Mohamed, Montaner, Luis J., Papasavvas, Emmanouil

“…Glycosylation plays a critical role in mediating several antibody (mainly immunoglobulin G; IgG) immunological functions, including antibody-dependent…”
Get full text