Search Results - "KOSTIN, Sawa"

Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells by Günther, Stefan, Kim, Johnny, Kostin, Sawa, Lepper, Christoph, Fan, Chen-Ming, Braun, Thomas

“…Skeletal muscle contains Pax7-expressing muscle stem or satellite cells, enabling muscle regeneration throughout most of adult life. Here, we demonstrate that…”
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Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation by Boonsanay, Verawan, Zhang, Ting, Georgieva, Angelina, Kostin, Sawa, Qi, Hui, Yuan, Xuejun, Zhou, Yonggang, Braun, Thomas

“…Skeletal muscle stem cells (MuSCs) are required for regeneration of adult muscle following injury, a response that demands activation of mainly quiescent…”
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Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster by Boettger, Thomas, Beetz, Nadine, Kostin, Sawa, Schneider, Johanna, Krüger, Marcus, Hein, Lutz, Braun, Thomas

“…VSMCs respond to changes in the local environment by adjusting their phenotype from contractile to synthetic, a phenomenon known as phenotypic modulation or…”
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Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice by Vakhrusheva, Olesya, Smolka, Christian, Gajawada, Praveen, Kostin, Sawa, Boettger, Thomas, Kubin, Thomas, Braun, Thomas, Bober, Eva

“…Sirt7 is a member of the mammalian sirtuin family consisting of 7 genes, Sirt1 to Sirt7, which all share a homology to the founding family member, the yeast…”
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Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling by Kubin, Thomas, Pöling, Jochen, Kostin, Sawa, Gajawada, Praveen, Hein, Stefan, Rees, Wolfgang, Wietelmann, Astrid, Tanaka, Minoru, Lörchner, Holger, Schimanski, Silvia, Szibor, Marten, Warnecke, Henning, Braun, Thomas

“…Cardiomyocyte remodeling, which includes partial dedifferentiation of cardiomyocytes, is a process that occurs during both acute and chronic disease processes…”
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Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2 by Belema-Bedada, Fikru, Uchida, Shizuka, Martire, Alessandra, Kostin, Sawa, Braun, Thomas

“…Circulating stem cells of different origin have been demonstrated to improve repair of various organs both after systemic and local application, although the…”
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Zonula occludens‐1 and connexin 43 expression in the failing human heart by Kostin, Sawa

“…Focal disorganization of gap junctional distribution and down‐regulation of the major gap junctional protein connexin 43 are typical features of myocardial…”
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The failing heart is a major source of circulating FGF23 via oncostatin M receptor activation by Richter, Manfred, MD, Lautze, Hans-Jürgen, MD, Walther, Thomas, MD, PhD, Braun, Thomas, MD, PhD, Kostin, Sawa, MD, PhD, Kubin, Thomas, PhD

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Myostatin induces interstitial fibrosis in the heart via TAK1 and p38 by Biesemann, Nadine, Mendler, Luca, Kostin, Sawa, Wietelmann, Astrid, Borchardt, Thilo, Braun, Thomas

“…Myostatin, a member of the TGF-β superfamily of secreted growth factors, is a negative regulator of skeletal muscle growth. In the heart, it is expressed at…”
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Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice by Seimetz, Michael, Parajuli, Nirmal, Pichl, Alexandra, Veit, Florian, Kwapiszewska, Grazyna, Weisel, Friederike C., Milger, Katrin, Egemnazarov, Bakytbek, Turowska, Agnieszka, Fuchs, Beate, Nikam, Sandeep, Roth, Markus, Sydykov, Akylbek, Medebach, Thomas, Klepetko, Walter, Jaksch, Peter, Dumitrascu, Rio, Garn, Holger, Voswinckel, Robert, Kostin, Sawa, Seeger, Werner, Schermuly, Ralph T., Grimminger, Friedrich, Ghofrani, Hossein A., Weissmann, Norbert

“…Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death worldwide. We report in an emphysema model of mice chronically exposed…”
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Fibrosis in endstage human heart failure: Severe changes in collagen metabolism and MMP/TIMP profiles by Polyakova, Victoria, Loeffler, Ivo, Hein, Stefan, Miyagawa, Shigeru, Piotrowska, Izabela, Dammer, Sebastian, Risteli, Juha, Schaper, Jutta, Kostin, Sawa

“…Abstract Objectives We studied fibrosis, collagen metabolism, MMPs/TIMPs and cytokine expression in various forms of human heart failure (HF) by quantitative…”
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Role of Extracellular RNA in Atherosclerotic Plaque Formation in Mice by Simsekyilmaz, Sakine, Cabrera-Fuentes, Hector A, Meiler, Svenja, Kostin, Sawa, Baumer, Yvonne, Liehn, Elisa A, Weber, Christian, Boisvert, William A, Preissner, Klaus T, Zernecke, Alma

“…BACKGROUND—Atherosclerosis and vascular remodeling after injury are driven by inflammation and mononuclear cell infiltration. Extracellular RNA (eRNA) has…”
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Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease by Kim, Hyun-Taek, Yin, Wenguang, Jin, Young-June, Panza, Paolo, Gunawan, Felix, Grohmann, Beate, Buettner, Carmen, Sokol, Anna M., Preussner, Jens, Guenther, Stefan, Kostin, Sawa, Ruppert, Clemens, Bhagwat, Aditya M., Ma, Xuefei, Graumann, Johannes, Looso, Mario, Guenther, Andreas, Adelstein, Robert S., Offermanns, Stefan, Stainier, Didier Y. R.

“…Impaired alveolar formation and maintenance are features of many pulmonary diseases that are associated with significant morbidity and mortality. In a forward…”
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Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown by Wiederstein, Janica Lea, Nolte, Hendrik, Günther, Stefan, Piller, Tanja, Baraldo, Martina, Kostin, Sawa, Bloch, Wilhelm, Schindler, Natalie, Sandri, Marco, Blaauw, Bert, Braun, Thomas, Hölper, Soraya, Krüger, Marcus

“…Protein aggregates and cytoplasmic vacuolization are major hallmarks of multisystem proteinopathies (MSPs) that lead to muscle weakness. Here, we identify…”
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Proteolysis regulates cardiomyocyte maturation and tissue integration by Fukuda, Ryuichi, Gunawan, Felix, Beisaw, Arica, Jimenez-Amilburu, Vanesa, Maischein, Hans-Martin, Kostin, Sawa, Kawakami, Koichi, Stainier, Didier Y. R.

“…Tissue integrity is critical for organ formation and function. During heart development, cardiomyocytes differentiate and integrate to form a coherent tissue…”
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Types of Cardiomyocyte Death and Clinical Outcomes in Patients With Heart Failure by Kostin, Sawa, MD, PhD

“…In addition to apoptosis (programmed cell death type I) and oncosis, accumulating evidence indicates the occurrence of a third mode of cell death (programmed…”
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Atrial fibrillation in human patients is associated with increased collagen type V and TGFbeta1 by Kostin, Sawa, Richter, Manfred, Ganceva, Natalia, Sasko, Benjamin, Giannakopoulos, Theodoros, Ritter, Oliver, Szalay, Zoltan, Pagonas, Nikolaos

“…Atrial fibrosis is an important factor in initiating and maintaining atrial fibrillation (AF). Collagen V belongs to fibrillar collagens. There are, however no…”
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BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development by Shin, Jaeyoung, Watanabe, Shuichi, Hoelper, Soraya, Krüger, Marcus, Kostin, Sawa, Pöling, Jochen, Kubin, Thomas, Braun, Thomas

“…Migration of skeletal muscle precursor cells is a key step during limb muscle development and depends on the activity of PAX3 and MET. Here, we demonstrate…”
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Soluble Adenylyl Cyclase Controls Mitochondria-dependent Apoptosis in Coronary Endothelial Cells by Kumar, Sanjeev, Kostin, Sawa, Flacke, Jan-Paul, Reusch, H. Peter, Ladilov, Yury

“…The cAMP signaling pathway plays an essential role in modulating the apoptotic response to various stress stimuli. Until now, it was attributed exclusively to…”
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Tissue-Engineered Cardiac Constructs for Cardiac Repair by Miyagawa, Shigeru, MD, PhD, Roth, Matthias, MD, Saito, Atsuhiro, PhD, Sawa, Yoshiki, MD, PhD, Kostin, Sawa, PhD

“…Several recent basic research studies have described surgical methods for cardiac repair using tissue cardiomyoplasty. This review summarizes recent advances…”
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