Search Results - "KOSTER, Joseph C"

Kir6.2 Variant E23K Increases ATP-Sensitive K+ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance by VILLAREAL, Dennis T, KOSTER, Joseph C, ROBERTSON, Heather, AKROUH, Alejandro, MIYAKE, Kazuaki, BELL, Graeme I, PATTERSON, Bruce W, NICHOLS, Colin G, POLONSKY, Kenneth S

“…Kir6.2 Variant E23K Increases ATP-Sensitive K + Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults…”
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The ATP-sensitive K +-channel (K ATP) controls early left–right patterning in Xenopus and chick embryos by Aw, Sherry, Koster, Joseph C., Pearson, Wade, Nichols, Colin G., Shi, Nian-Qing, Carneiro, Katia, Levin, Michael

“…Consistent left–right asymmetry requires specific ion currents. We characterize a novel laterality determinant in Xenopus laevis: the ATP-sensitive K +-channel…”
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An ATP-Binding Mutation (G334D) in KCNJ11 Is Associated With a Sulfonylurea-Insensitive Form of Developmental Delay, Epilepsy, and Neonatal Diabetes by MASIA, Ricard, KOSTER, Joseph C, TUMINI, Stefano, CHIARELLI, Francesco, COLOMBO, Carlo, NICHOLS, Colin G, BARBETTI, Fabrizio

“…An ATP-Binding Mutation (G334D) in KCNJ11 Is Associated With a Sulfonylurea-Insensitive Form of Developmental Delay, Epilepsy, and Neonatal Diabetes Ricard…”
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Critical role of gap junction coupled KATP channel activity for regulated insulin secretion by Rocheleau, Jonathan V, Remedi, Maria S, Granada, Butch, Head, W Steven, Koster, Joseph C, Nichols, Colin G, Piston, David W

“…Pancreatic beta-cells secrete insulin in response to closure of ATP-sensitive K+ (KATP) channels, which causes membrane depolarization and a concomitant rise…”
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Muscle KATP channels: recent insights to energy sensing and myoprotection by Flagg, Thomas P, Enkvetchakul, Decha, Koster, Joseph C, Nichols, Colin G

“…ATP-sensitive potassium (K(ATP)) channels are present in the surface and internal membranes of cardiac, skeletal, and smooth muscle cells and provide a unique…”
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HIV Protease Inhibitors Acutely Impair Glucose-Stimulated Insulin Release by KOSTER, Joseph C, REMEDI, Maria S, HAIJUN QIU, NICHOLS, Colin G, HRUZ, Paul W

“…HIV Protease Inhibitors Acutely Impair Glucose-Stimulated Insulin Release Joseph C. Koster 1 , Maria S. Remedi 1 , Haijun Qiu 2 , Colin G. Nichols 1 and Paul…”
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Expression of ATP-Insensitive KATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes by KOSTER, Joseph C, REMEDI, Maria S, MASIA, Ricard, PATTON, Brian, TONG, Ailing, NICHOLS, Colin G

“…Expression of ATP-Insensitive K ATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes Joseph C. Koster , Maria S. Remedi , Ricard…”
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Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K+ Channels by REMEDI, Maria S, KOSTER, Joseph C, MARKOVA, Kamelia, SEINO, Susumu, MIKI, Takashi, PATTON, Brian L, MCDANIEL, Michael L, NICHOLS, Colin G

“…Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K + Channels Maria S. Remedi 1 2 , Joseph. C. Koster 1 , Kamelia Markova 1 ,…”
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The G53D Mutation in Kir6.2 (KCNJ11) Is Associated with Neonatal Diabetes and Motor Dysfunction in Adulthood that Is Improved with Sulfonylurea Therapy by Koster, Joseph C., Cadario, Francesco, Peruzzi, Cinzia, Colombo, Carlo, Nichols, Colin G., Barbetti, Fabrizio

“…Context: Mutations in the Kir6.2 subunit (KCNJ11) of the ATP-sensitive potassium channel (KATP) underlie neonatal diabetes mellitus. In severe cases, Kir6.2…”
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Effects of the HIV Protease Inhibitor Ritonavir on GLUT4 Knock-out Mice by Vyas, Arpita Kalla, Koster, Joseph C., Tzekov, Anatoly, Hruz, Paul W.

“…HIV protease inhibitors acutely block glucose transporters (GLUTs) in vitro, and this may contribute to altered glucose homeostasis in vivo. However, several…”
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KATP channelopathies in the pancreas by Remedi, Maria S., Koster, Joseph C.

“…Adenosine-triphosphate-sensitive potassium channels (K ATP ) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical…”
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ATP-Sensitive K+ Channel Signaling in Glucokinase-Deficient Diabetes by REMEDI, Maria S, KOSTER, Joseph C, PATTON, Brian L, NICHOLS, Colin G

“…ATP-Sensitive K + Channel Signaling in Glucokinase-Deficient Diabetes Maria S. Remedi , Joseph C. Koster , Brian L. Patton and Colin G. Nichols From the…”
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Diabetes and insulin secretion : The ATP-sensitive K+ channel (KATP) connection by KOSTER, Joseph C, PERMUTT, M. Alan, NICHOLS, Colin G

“…The ATP-sensitive K+ channel (K ATP channel) senses metabolic changes in the pancreatic beta-cell, thereby coupling metabolism to electrical activity and…”
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Hypotension Due to Kir6.1 Gain‐of‐Function in Vascular Smooth Muscle by Li, Anlong, Knutsen, Russell H., Zhang, Haixia, Osei‐Owusu, Patrick, Moreno‐Dominguez, Alex, Harter, Theresa M., Uchida, Keita, Remedi, Maria S., Dietrich, Hans H., Bernal‐Mizrachi, Carlos, Blumer, Kendall J., Mecham, Robert P., Koster, Joseph C., Nichols, Colin G.

“…Background KATP channels, assembled from pore‐forming (Kir6.1 or Kir6.2) and regulatory (SUR1 or SUR2) subunits, link metabolism to excitability. Loss of…”
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ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes : Implications for pharmacogenomic therapy by KOSTER, Joseph C, REMEDI, Maria S, DAO, Crystal, NICHOLS, Colin G

“…The prediction that overactivity of the pancreatic ATP-sensitive K(+) channel (K(ATP) channel) underlies reduced insulin secretion and causes a diabetic…”
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DEND mutation in Kir6.2 (KCNJ11) reveals a flexible N-terminal region critical for ATP-sensing of the KATP channel by Koster, Joseph C, Kurata, Harley T, Enkvetchakul, Decha, Nichols, Colin G

“…ATP-sensitive K(+)-channels link metabolism and excitability in neurons, myocytes, and pancreatic islets. Mutations in the pore-forming subunit (Kir6.2;…”
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Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation by Wambach, Jennifer A, Marshall, Bess A, Koster, Joseph C, White, Neil H, Nichols, Colin G

“…Wambach JA, Marshall BA, Koster JC, White NH, Nichols CG. Successful sulfonylurea treatment of an insulin‐naïve neonate with diabetes mellitus due to a KCNJ11…”
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Congenital Hyperinsulinism and Glucose Hypersensitivity in Homozygous and Heterozygous Carriers of Kir6.2 ( KCNJ11 ) Mutation V290M Mutation by Loechner, Karen J., Akrouh, Alejandro, Kurata, Harley T., Dionisi-Vici, Carlo, Maiorana, Arianna, Pizzoferro, Milena, Rufini, Vittoria, de Ville de Goyet, Jean, Colombo, Carlo, Barbetti, Fabrizio, Koster, Joseph C., Nichols, Colin G.

“…OBJECTIVE The ATP-sensitive K+ channel (KATP) controls insulin secretion from the islet. Gain- or loss-of-function mutations in channel subunits underlie human…”
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Tolerance for ATP-Insensitive KATP Channels in Transgenic Mice by Koster, Joseph C, Knopp, Andreas, Flagg, Thomas P, Markova, Kamelia P, Sha, Qun, Enkvetchakul, Decha, Betsuyaku, Tetsuo, Yamada, Kathryn A, Nichols, Colin G

“…To examine the role of sarcolemmal KATP channels in cardiac function, we generated transgenic mice expressing GFP-tagged Kir6.2 subunits with reduced ATP…”
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Diabetes and Insulin Secretion by Koster, Joseph C., Permutt, M. Alan, Nichols, Colin G.

“…Diabetes and Insulin Secretion The ATP-Sensitive K + Channel (K ATP ) Connection Joseph C. Koster , M. Alan Permutt and Colin G. Nichols Department of Cell…”
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