Search Results - "KOSTEN, Therese A"

The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats by Haile, Colin N., Kosten, Therese A.

“…Fibrates are a class of medications used to treat hypercholesterolemia and dyslipidemia that target nuclear peroxisome proliferator-activated receptors…”
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Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence by Gomez, Juan L., Cunningham, Christopher L., Finn, Deborah A., Young, Emily A., Helpenstell, Lily K., Schuette, Lindsey M., Fidler, Tara L., Kosten, Therese A., Ryabinin, Andrey E.

“…An effort has been mounted to understand the mechanisms of alcohol dependence in a way that may allow for greater efficacy in treatment. It has long been…”
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Repeated Unpredictable Stress and Antidepressants Differentially Regulate Expression of the Bcl-2 Family of Apoptotic Genes in Rat Cortical, Hippocampal, and Limbic Brain Structures by KOSTEN, Therese A, GALLOWAY, Matthew P, DUMAN, Ronald S, RUSSELL, David S, D'SA, Carrol

“…Apoptosis has been proposed as a contributing cellular mechanism to the structural alterations that have been observed in stress-related mood disorders…”
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Short-Term Tropisetron Treatment and Cognitive and P50 Auditory Gating Deficits in Schizophrenia by Zhang, Xiang Yang, Liu, Lei, Liu, Shaowen, Hong, Xiaohong, Chen, Da Chun, Xiu, Mei Hong, De Yang, Fu, Zhang, Zhijun, Zhang, Xiangrong, Kosten, Therese A., Kosten, Thomas R.

“…ObjectiveThe α7 nicotinic acetylcholine receptor (nAChR) is associated with cognitive and P50 auditory gating deficits in schizophrenia, and α7 nAChR agonists…”
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A vaccine against methamphetamine attenuates its behavioral effects in mice by Shen, Xiaoyun Y, Kosten, Therese A, Lopez, Angel Y, Kinsey, Berma M, Kosten, Thomas R, Orson, Frank M

“…Abstract Background Vaccines have treatment potential for methamphetamine (MA) addiction. We tested whether a conjugate vaccine against MA…”
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Early life stress impairs fear conditioning in adult male and female rats by Kosten, Therese A., Lee, Hongjoo J., Kim, Jeansok J.

“…We demonstrated that neonatal isolation (1-h pup isolation; postnatal days 2–9) impairs context-induced fear conditioning in adult male rats and tends to…”
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Cigarette smoking and cognitive function in Chinese male schizophrenia: a case-control study by Zhang, Xiang Yang, Chen, Da Chun, Xiu, Mei Hong, Haile, Colin N, Sun, Hongqiang, Lu, Lin, Kosten, Therese A, Kosten, Thomas R

“…Schizophrenic patients have higher smoking rates than the general population. Studies show that smoking may be a form of self-medication in an attempt to…”
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Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba by Zhang, Xiang Yang, Zhang, Wu-Fang, Zhou, Dong-Feng, Chen, Da Chun, Xiu, Mei Hong, Wu, Hao-Ran, Haile, Colin N, Kosten, Therese A, Kosten, Thomas R

“…Background Tardive dyskinesia (TD) has no well-accepted treatments or known pathophysiology, but low brain-derived neurotrophic factor (BDNF) may play an…”
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An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats by Haile, Colin N, Baker, Miah D, Sanchez, Sergio A, Lopez Arteaga, Carlos A, Duddupudi, Anantha L, Cuny, Gregory D, Norton, Elizabeth B, Kosten, Thomas R, Kosten, Therese A

“…Fentanyl (FEN) is a potent synthetic opioid associated with increasing incidence of opioid use disorder (OUD) and fatal opioid overdose. Vaccine immunotherapy…”
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Stress effects in the hippocampus: synaptic plasticity and memory by Kim, Jeansok J, Song, Eun Young, Kosten, Therese A

“…It is now well-documented that exposures to uncontrollable (inescapable and unpredictable) stress in adulthood can have profound effects on brain and behavior…”
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Immune receptor toll-like receptor 4 contributes to stress-induced affective responses in a sex-specific manner by Quave, Cana B., Nieto, Steven J., Haile, Colin N., Kosten, Therese A.

“…Stress activates innate immune Toll-like receptors (TLRs) and enhances susceptibility to depression, a condition that is more prevalent in females. The TLR4…”
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Active and Passive Immunization with an Anti-Methamphetamine Vaccine Attenuates the Behavioral and Cardiovascular Effects of Methamphetamine by Haile, Colin N, Varner, Kurt J, Huijing, Xia, Arora, Reetakshi, Orson, Frank M, Kosten, Thomas R, Kosten, Therese A

“…Background: Methamphetamine use disorder (MUD) is a growing health concern with no FDA-approved treatment. The present series of studies build upon our…”
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Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge by Stone, Addison E., Scheuermann, Sarah E., Haile, Colin N., Cuny, Gregory D., Velasquez, Marcela Lopez, Linhuber, Joshua P., Duddupudi, Anantha L., Vigliaturo, Jennifer R., Pravetoni, Marco, Kosten, Therese A., Kosten, Thomas R., Norton, Elizabeth B.

“…Fentanyl is a major contributor to the devastating increase in overdose deaths from substance use disorders (SUD). A vaccine targeting fentanyl could be a…”
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Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes by Zhang, Xiang Yang, Liang, Jun, Chen, Da Chun, Xiu, Mei Hong, He, Jincai, Cheng, Wei, Wu, Zhiwei, Yang, Fu De, Haile, Colin N, Sun, Hongqiang, Lu, Lin, Kosten, Therese A, Kosten, Thomas R

“…The high prevalence of smoking in schizophrenia of European background may be related to smoking's reducing clinical symptoms and medication side effects…”
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Immediate and enduring effects of neonatal isolation on maternal behavior in rats by Kosten, Therese A., Kehoe, Priscilla

“…Previously, we showed that neonatal isolation (1‐h isolation/day from dam, litter, and nest on PND 2–9) facilitates cocaine self‐administration and increases…”
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Dual Modulation of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Protects against Excitotoxicity by Karanian, David A, Brown, Queenie B, Makriyannis, Alexandros, Kosten, Therese A, Bahr, Ben A

“…The endocannabinoid system has been suggested to elicit signals that defend against several disease states including excitotoxic brain damage. Besides direct…”
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BDNF Val66Met variant and smoking in a Chinese population by Zhang, Xiang Yang, Chen, Da Chun, Xiu, Mei Hong, Luo, Xingguang, Zuo, Lingjun, Haile, Colin N, Kosten, Therese A, Kosten, Thomas R

“…Several recent studies have supported the hypothesis that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, might be…”
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Gender Differences in Never-Medicated First-Episode Schizophrenia and Medicated Chronic Schizophrenia Patients by XIANG YANG ZHANG, DA CHUN CHEN, MEI HONG XIU, FU DE YANG, HAILE, Colin N, KOSTEN, Therese A, KOSTEN, Thomas R

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Pharmacogenetic Treatments for Drug Addiction: Cocaine, Amphetamine and Methamphetamine by Haile, Colin N., Kosten, Thomas R., Kosten, Therese A.

“…Background: Pharmacogenetics uses genetic variation to predict individual differences in response to medications and holds much promise to improve treatment of…”
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Early life stress and the propensity to develop addictive behaviors by Walters, Hailey, Kosten, Therese A.

“…•Early life stress enhances behavioral responses to opiates and stimulants and to some extent, alcohol.•Some long-term consequences of early life stress are…”
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