Search Results - "KOSKI, K. M"

Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene by MALKINSON, A. M, KOSKI, K. M, EVANS, W. A, FESTING, M. F. W

“…Chronic butylated hydroxytoluene (BHT) treatment after a single administration of a carcinogen increases lung tumor multiplicity in some inbred strains of…”
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Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone) by MALKINSON, A. M, KOSKI, K. M, DWYER-NIELD, L. D, RICE, P. L, RIOUX, N, CASTONGUAY, A, AHNEN, D. J, THOMPSON, H, PAMUKCU, R, PIAZZA, G. A

“…The sulfone derivative of the non-steroidal anti-inflammatory drug (NSAID), sulindac, has been reported to inhibit mammary and colon tumor formation in rodent…”
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Mutational Spectrum of d-Bifunctional Protein Deficiency and Structure-Based Genotype-Phenotype Analysis by Ferdinandusse, Sacha, Ylianttila, Mari S., Gloerich, Jolein, Koski, M. Kristian, Oostheim, Wendy, Waterham, Hans R., Hiltunen, J. Kalervo, Wanders, Ronald J.A., Glumoff, Tuomo

“…d-bifunctional protein (DBP) deficiency is an autosomal recessive inborn error of peroxisomal fatty acid oxidation. The clinical presentation of DBP deficiency…”
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A Two-domain Structure of One Subunit Explains Unique Features of Eukaryotic Hydratase 2 by Koski, M Kristian, Haapalainen, Antti M, Hiltunen, J Kalervo, Glumoff, Tuomo

“…2-Enoyl-CoA hydratase 2, a part from multifunctional enzyme type 2, hydrates trans -2-enoyl-CoA to 3-hydroxyacyl-CoA in the (3 R )-hydroxy-dependent route of…”
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Human peroxisomal multifunctional enzyme type 2. Site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity by Qin, Y M, Haapalainen, A M, Kilpeläinen, S H, Marttila, M S, Koski, M K, Glumoff, T, Novikov, D K, Hiltunen, J K

“…Beta-oxidation of acyl-CoAs in mammalian peroxisomes can occur via either multifunctional enzyme type 1 (MFE-1) or type 2 (MFE-2), both of which catalyze the…”
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Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells by Rice, Pamela L., Porter, Stephanie E., Koski, Kelli M., Ramakrishna, Gayatri, Chen, Aaron, Schrump, David, Kazlauskas, Andrius, Malkinson, Alvin M.

“…The roles of growth factors in mouse lung neoplasia were investigated by examining receptors for platelet‐derived growth factor (PDGF) and epidermal growth…”
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Crystal Structure of 2-Enoyl-CoA Hydratase 2 from Human Peroxisomal Multifunctional Enzyme Type 2 by Kristian Koski, M., Haapalainen, Antti M., Hiltunen, J. Kalervo, Glumoff, Tuomo

“…2-Enoyl-CoA hydratase 2 is the middle part of the mammalian peroxisomal multifunctional enzyme type 2 (MFE-2), which is known to be important in the…”
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Structural biology of the thioester-dependent degradation and synthesis of fatty acids by Bhaumik, Prasenjit, Koski, M Kristian, Glumoff, Tuomo, Hiltunen, J Kalervo, Wierenga, Rik K

“…The fatty acid degradation and synthesis pathways consist of the same four chemical transformations. These transformations are facilitated by conjugating the…”
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Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2 by Koski, M. Kristian, Haapalainen, Antti M., Hiltunen, J. Kalervo, Glumoff, Tuomo

“…In yeast, the second and the third reaction of the fatty‐acid β‐­oxidation spiral are catalysed by peroxisomal multifunctional enzyme type 2 (Mfe2p/Fox2p)…”
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