Search Results - "KOSAKA, Kunio"

Carnosic acid (CA) prevents lipid accumulation in hepatocytes through the EGFR/MAPK pathway by Wang, Ting, Takikawa, Yasuhiro, Tabuchi, Takahito, Satoh, Takumi, Kosaka, Kunio, Suzuki, Kazuyuki

“…Background Carnosic acid (CA), found in rosemary, has been reported to have antioxidant and anti-adipogenic properties. We recently demonstrated that CA…”
Get full text

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models by Lipton, Stuart A, Rezaie, Tayebeh, Nutter, Anthony, Lopez, Kevin M, Parker, James, Kosaka, Kunio, Satoh, Takumi, McKercher, Scott R, Masliah, Eliezer, Nakanishi, Nobuki

“…Alzheimer’s disease (AD) is characterized by synaptic and neuronal loss, which occurs at least partially through oxidative stress induced by oligomeric…”
Get full text

Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism by Takahashi, Toshiyuki, Tabuchi, Takahito, Tamaki, Yosei, Kosaka, Kunio, Takikawa, Yasuhiro, Satoh, Takumi

“…In the previous studies, we reported that carnosic acid (CA) and carnosol (CS) originating from rosemary protected cortical neurons by activating the…”
Get full text

Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis by Shimojo, Yosuke, Kosaka, Kunio, Noda, Yoshihiro, Shimizu, Takahiko, Shirasawa, Takuji

“…Amyotrophic lateral sclerosis (ALS) is a late‐onset progressive neurodegenerative disease affecting motor neurons. About 2% of patients with the disease are…”
Get full text

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes by Mimura, Junsei, Inose-Maruyama, Atsushi, Taniuchi, Shusuke, Kosaka, Kunio, Yoshida, Hidemi, Yamazaki, Hiromi, Kasai, Shuya, Harada, Nobuhiko, Kaufman, Randal J, Oyadomari, Seiichi, Itoh, Ken

“…Carnosic acid (CA) is a phytochemical found in some dietary herbs, such as L., and possesses antioxidative and anti-microbial properties. We previously…”
Get full text

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells by Kosaka, Kunio, Mimura, Junsei, Itoh, Ken, Satoh, Takumi, Shimojo, Yosuke, Kitajima, Chieko, Maruyama, Atsushi, Yamamoto, Masayuki, Shirasawa, Takuji

“…Neurotrophins such as NGF promote neuronal survival and differentiation via the cell surface TrkA neurotrophin receptor. Compounds with neurotrophic actions…”
Get full text

Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration by Rezaie, Tayebeh, McKercher, Scott R, Kosaka, Kunio, Seki, Masaaki, Wheeler, Larry, Viswanath, Veena, Chun, Teresa, Joshi, Rabina, Valencia, Marcos, Sasaki, Shunsuke, Tozawa, Terumasa, Satoh, Takumi, Lipton, Stuart A

“…The herb rosemary has been reported to have antioxidant and anti-inflammatory activity. We have previously shown that carnosic acid (CA), present in rosemary…”
Get full text

Carnosic acid attenuates apoptosis induced by amyloid-β 1–42 or 1–43 in SH-SY5Y human neuroblastoma cells by Meng, Pengfei, Yoshida, Hidemi, Tanji, Kunikazu, Matsumiya, Tomoh, Xing, Fei, Hayakari, Ryo, Wang, Liang, Tsuruga, Kazushi, Tanaka, Hiroshi, Mimura, Junsei, Kosaka, Kunio, Itoh, Ken, Takahashi, Ippei, Kawaguchi, Shogo, Imaizumi, Tadaatsu

“…•Aβ42 and Aβ43 induced apoptosis in cultured human neuroblastoma cells.•Carnosic acid (CA, 10μM) attenuated the Aβ42/43-induced apoptosis.•CA suppressed the…”
Get full text

Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice by Wang, Ting, Takikawa, Yasuhiro, Satoh, Takumi, Yoshioka, Yoshichika, Kosaka, Kunio, Tatemichi, Yoshinori, Suzuki, Kazuyuki

“…Aim:  Carnosic acid (CA) inhibits adipogenesis in vitro. The present study evaluated the therapeutic effects of CA in ob/ob mice. Methods:  The experimental…”
Get full text

Activated glutathione metabolism participates in protective effects of carnosic acid against oxidative stress in neuronal HT22 cells by Tamaki, Yosei, Tabuchi, Takahito, Takahashi, Toshiyuki, Kosaka, Kunio, Satoh, Takumi

“…In our previous studies, we have reported that carnosic acid (CA) and carnosol (CS) originating from rosemary protects cortical neurons by inducing phase 2…”
Get more information

Carnosic acid suppresses the production of amyloid-β 1-42 and 1-43 by inducing an α-secretase TACE/ADAM17 in U373MG human astrocytoma cells by Yoshida, Hidemi, Meng, Pengfei, Matsumiya, Tomoh, Tanji, Kunikazu, Hayakari, Ryo, Xing, Fei, Wang, Liang, Tsuruga, Kazushi, Tanaka, Hiroshi, Mimura, Junsei, Kosaka, Kunio, Itoh, Ken, Takahashi, Ippei, Imaizumi, Tadaatsu

“…Amyloid beta (Aβ) peptides are key molecules in the pathogenesis of Alzheimer's disease (AD). The sequential cleavage of amyloid precursor protein (APP) by the…”
Get full text

Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes by Mimura, Junsei, Kosaka, Kunio, Maruyama, Atsushi, Satoh, Takumi, Harada, Nobuhiko, Yoshida, Hidemi, Satoh, Kei, Yamamoto, Masayuki, Itoh, Ken

“…Nerve growth factor (NGF) is a neurotrophic factor that plays an important role in neuronal cell development and survival. Carnosic acid (CA), a hydrophobic…”
Get full text

Carnosic acid suppresses the production of amyloid-β 1–42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells by Meng, Pengfei, Yoshida, Hidemi, Matsumiya, Tomoh, Imaizumi, Tadaatsu, Tanji, Kunikazu, Xing, Fei, Hayakari, Ryo, Dempoya, Junichi, Tatsuta, Tetsuya, Aizawa-Yashiro, Tomomi, Mimura, Junsei, Kosaka, Kunio, Itoh, Ken, Satoh, Kei

“…► Carnosic acid (CA) lowered Aβ42 production in cultured human neuroblastoma cells. ► CA enhanced the expression of α-secretase TACE without inducing…”
Get full text

Carnosic acid protects neuronal HT22 Cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners by Satoh, Takumi, Izumi, Masanori, Inukai, Yuki, Tsutsumi, Yasutaka, Nakayama, Naoto, Kosaka, Kunio, Shimojo, Yosuke, Kitajima, Chieko, Itoh, Ken, Yokoi, Toshio, Shirasawa, Takuji

“…In a previous study, we found that carnosic acid (CA) protected cortical neurons by activating the Keap1/Nrf2 pathway, which activation was initiated by…”
Get full text

Carnosic Acid, a Component of Rosemary (Rosmarinus officinalis L.), Promotes Synthesis of Nerve Growth Factor in T98G Human Glioblastoma Cells by Kosaka, Kunio, Yokoi, Toshio

“…Nerve growth factor (NGF) is a factor vital for the growth and functional maintenance of nerve tissue. The authors found that a rosemary (Rosmarinus…”
Get full text

Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation by Yoshida, Hidemi, Mimura, Junsei, Imaizumi, Tadaatsu, Matsumiya, Tomoh, Ishikawa, Akira, Metoki, Norifumi, Tanji, Kunikazu, Ota, Ken, Hayakari, Ryo, Kosaka, Kunio, Itoh, Ken, Satoh, Kei

“…▶ Edaravone and carnosic acid significantly enhance NGF expression in human astrocytes. ▶ This effect is observed during hypoxia/reoxygenation as well as under…”
Get full text

Byelyankacin: a novel melanogenesis inhibitor produced by Enterobacter sp. B20 by Takahashi, Senji, Iwai, Hiroki, Kosaka, Kunio, Miyazaki, Toshitsugu, Osanai, Yuko, Arao, Nakako, Tanaka, Kouichi, Nagai, Koji, Nakagawa, Akira

“…A novel melanogenesis inhibitor, byelyankacin (1), was isolated from the fermentation broth of a bacterial strain. The producing organism, designated B20, was…”
Get full text

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1 by Satoh, Takumi, Kosaka, Kunio, Itoh, Ken, Kobayashi, Akira, Yamamoto, Masayuki, Shimojo, Yosuke, Kitajima, Chieko, Cui, Jiankun, Kamins, Joshua, Okamoto, Shu-ichi, Izumi, Masanori, Shirasawa, Takuji, Lipton, Stuart A

“…Electrophilic compounds are a newly recognized class of redox-active neuroprotective compounds with electron deficient, electrophilic carbon centers that react…”
Get full text

DEVELOPMENT OF A NOVEL NEUROPROTECTIVE STRATEGY BY THE COOPERATIVE TRANSCRIPTIONAL NETWORK CENTERED ON Nrf2 by Itoh, Ken, Mimura, Junsei, Ye, Peng, Yoshida, Hidemi, Kosaka, Kunio

Get full text

P10 - DEVELOPMENT OF A NOVEL NEUROPROTECTIVE STRATEGY BY THE COOPERATIVE TRANSCRIPTIONAL NETWORK CENTERED ON Nrf2 by Itoh, Ken, Mimura, Junsei, Ye, Peng, Yoshida, Hidemi, Kosaka, Kunio

Get full text