Search Results - "KORTH, Michael"

Dual role of protein kinase C on BK channel regulation by Zhou, Xiao-Bo, Wulfsen, Iris, Utku, Emine, Sausbier, Ulrike, Sausbier, Matthias, Wieland, Thomas, Ruth, Peter, Korth, Michael

“…Large conductance voltage- and Ca²⁺-activated potassium channels (BK channels) are important feedback regulators in excitable cells and are potently regulated…”
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Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C by Zhou, Xiaobo, Wulfsen, Iris, Korth, Michael, McClafferty, Heather, Lukowski, Robert, Shipston, Michael J., Ruth, Peter, Dobrev, Dobromir, Wieland, Thomas

“…Large-conductance, calcium- and voltage-gated potassium (BK) channels play an important role in cellular excitability by controlling membrane potential and…”
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Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice by SAUSBIER, Matthias, AMTZ, Claudia, ABDULLAH, Usamah, KRIPPEIT-DREWS, Peter, FEIL, Robert, HOFMANN, Franz, KNAUS, Hans-Günier, KENYON, Chris, SHIPSTON, Michael J, STORM, Johan F, NEUHUBER, Winfried, KORTH, Michael, BUCURENCIU, Iancu, SCHUBERT, Rudolf, GOLLASCH, Maik, RUTH, Peter, HONG ZHAO, ZHOU, Xiao-Bo, SAUSBIER, Ulrike, FEIL, Susanne, KAMM, Simone, ESSIN, Kyrill, SAILER, Claudia A

“…Abnormally elevated blood pressure is the most prevalent risk factor for cardiovascular disease. The large-conductance, voltage- and Ca2+-dependent K+ (BK)…”
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A Molecular Switch for Specific Stimulation of the BKCa Channel by cGMP and cAMP Kinase by Zhou, X B, Arntz, C, Kamm, S, Motejlek, K, Sausbier, U, Wang, G X, Ruth, P, Korth, M

“…The cGMP and the cAMP pathways control smooth muscle tone by regulation of BK Ca (BK) channel activity. BK channels show considerable diversity and plasticity…”
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M2 Muscarinic Receptors Induce Airway Smooth Muscle Activation via a Dual, Gβγ-mediated Inhibition of Large Conductance Ca2+-activated K+ Channel Activity by Zhou, Xiao-Bo, Wulfsen, Iris, Lutz, Susanne, Utku, Emine, Sausbier, Ulrike, Ruth, Peter, Wieland, Thomas, Korth, Michael

“…Airway smooth muscle is richly endowed with muscarinic receptors of the M2 and M3 subtype. Stimulation of these receptors inhibits large conductance…”
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Oxytocin Receptors Differentially Signal via Gq and Gi Proteins in Pregnant and Nonpregnant Rat Uterine Myocytes: Implications for Myometrial Contractility by Zhou, Xiao-Bo, Lutz, Susanne, Steffens, Frank, Korth, Michael, Wieland, Thomas

“…Oxytocin (OT) receptors are important regulators of myometrial contractility. By using the activity of large conductance Ca2+-activated K+ (BKCa) channels as…”
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Protein Phosphatase 2A Is Essential for the Activation of Ca2+-activated K+ Currents by cGMP-dependent Protein Kinase in Tracheal Smooth Muscle and Chinese Hamster Ovary Cells by Zhou, Xiao-Bo, Ruth, Peter, Schlossmann, Jens, Hofmann, Franz, Korth, Michael

“…The regulation of Ca2+-activated K+ channels (KCa channels) by cGMP-dependent protein kinase (cGMP kinase) and its molecular mechanism were investigated in…”
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Effects of Doxorubicin on Excitation-Contraction Coupling in Guinea Pig Ventricular Myocardium by Wang, Yong-Xiao, Korth, Michael

“…Doxorubicin, an anticancer drug, was recently shown to release Ca sup 2 plus from cardiac sarcoplasmic reticulum (SR) by increasing the open probability of Ca…”
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Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity by Zhou, Xiao‐Bo, Wang, Ge‐Xin, Hüneke, Bernd, Wieland, Thomas, Korth, Michael

“…We used large conductance Ca 2+ -activated K + (BK Ca ) channel activity as a probe to characterize the inhibitory/stimulatory G protein (G i /G s ) signalling…”
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Effects of mitoxantrone on excitation-contraction coupling in guinea pig ventricular myocytes by Wang, G X, Zhou, X B, Korth, M

“…The mechanisms of the inotropic effect of mitoxantrone (MTO), a synthetic dihydroxyanthracenedione derivative with antineoplastic activity, was investigated in…”
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Effects of mitoxantrone on action potential and membrane currents in isolated cardiac myocytes by Wang, Ge‐Xin, Zhou, Xiao‐Bo, Eschenhagen, Thomas, Korth, Michael

“…The effects of mitoxantrone (MTO), an anticancer drug, on the membrane electrical properties of cardiac myocytes were investigated using the whole‐cell clamp…”
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Nucleoside Diphosphate Kinase B–Activated Intermediate Conductance Potassium Channels Are Critical for Neointima Formation in Mouse Carotid Arteries by Zhou, Xiao-Bo, Feng, Yu-Xi, Sun, Qiang, Lukowski, Robert, Qiu, Yi, Spiger, Katharina, Li, Zhai, Ruth, Peter, Korth, Michael, Skolnik, Edward Y, Borggrefe, Martin, Dobrev, Dobromir, Wieland, Thomas

“…OBJECTIVE—Vascular smooth muscle cells (VSMC) proliferation is a hallmark of atherosclerosis and vascular restenosis. The intermediate conductance Ca-activated…”
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Differential Class III Antiarrhythmic Effects of Ambasilide and Dofetilide at Different Extracellular Potassium and Pacing Frequencies by Gjini, Viktor, Korth, Michael, Schreieck, Jürgen, Weyerbrock, Sonja, Schömig, Albert, Schmitt, Claus

“…SUMMARYWe studied the effect of two new class III antiarrhythmics, ambasilide and dofetilide, on the action potential duration (APD) of guinea pig right…”
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Effects of several phosphodiesterase-inhibitors on guinea-pig myocardium by Korth, M

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Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ by SCHLOSSMANN, J, AMMENDOLA, A, HOFMANN, F, RUTH, P, ASHMAN, K, XIANGANG ZONG, HUBER, A, NEUBAUER, G, WANG, G.-X, ALLESCHER, H.-D, KORTH, M, WLLM, M

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Muscarinic receptors mediate negative and positive inotropic effects in mammalian ventricular myocardium: differentiation by agonists by Korth, Michael, Kühlkamp, Volker

“…1 The concentration‐dependence of the negative and positive inotropic effect of choline esters and of oxotremorine was studied in isometrically contracting…”
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Muscarinic receptor-mediated increase of intracellular Na+-ion activity and force of contraction by KORTH, M, KUHLKAMP, V

“…The aim of the present study was to determine the mechanism of the positive inotropic effect of carbachol on ventricular myocardium. Carbachol produced a…”
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Mechanisms of NO/cGMP-Dependent Vasorelaxation by Sausbier, Matthias, Schubert, Rudolf, Voigt, Viktor, Hirneiss, Christoph, Pfeifer, Alexander, Korth, Michael, Kleppisch, Thomas, Ruth, Peter, Hofmann, Franz

“…ABSTRACT—Both cGMP-dependent and -independent mechanisms have been implicated in the regulation of vascular tone by NO. We analyzed acetylcholine (ACh)- and…”
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Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1 by Wieland, Thomas, Hippe, Hans-Jörg, Ludwig, Katrin, Zhou, Xiao-Bo, Korth, Michael, Klumpp, Susanne

“…Regulation of protein phosphorylation by kinases and phosphatases is involved in many signaling pathways in mammalian cells. In contrast to prokaryotes and…”
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Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder by Sprossmann, Franz, Pankert, Patrick, Sausbier, Ulrike, Wirth, Angela, Zhou, Xiao-Bo, Madlung, Johannes, Zhao, Hong, Bucurenciu, Iancu, Jakob, Andreas, Lamkemeyer, Tobias, Neuhuber, Winfried, Offermanns, Stefan, Shipston, Michael J, Korth, Michael, Nordheim, Alfred, Ruth, Peter, Sausbier, Matthias

“…The large-conductance, voltage-dependent and Ca²⁺-dependent K⁺ (BK) channel links membrane depolarization and local increases in cytosolic free Ca²⁺ to…”
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