Search Results - "KORPOS, Eva"
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Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes
Published in Diabetologia (01-07-2021)“…Aims/hypothesis We and others previously reported the presence of tertiary lymphoid organs (TLOs) in the pancreas of NOD mice, where they play a role in the…”
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Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration
Published in Cell reports (Cambridge) (24-02-2015)“…Although chemokines are sufficient for chemotaxis of various cells, increasing evidence exists for their fine-tuning by selective proteolytic processing. Using…”
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The Voltage-Gated Hv1 H + Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells
Published in International journal of molecular sciences (25-03-2023)“…Myeloid-derived suppressor cells (MDSCs) are key determinants of the immunosuppressive microenvironment in tumors. As ion channels play key roles in the…”
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CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice
Published in Diabetes (New York, N.Y.) (01-10-2019)“…Tumors induce tolerance toward their antigens by producing the chemokine CCL21, leading to the formation of tertiary lymphoid organs (TLOs). Ins2-CCL21…”
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Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues
Published in Neural regeneration research (01-06-2015)“…The extracellular matrix (ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration,…”
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Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus
Published in Journal of neuroinflammation (22-08-2018)“…Very late antigen 4 (VLA-4; integrin α4β1) is critical for transmigration of T helper (T ) 1 cells into the central nervous system (CNS) under inflammatory…”
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Brain endothelial TAK1 and NEMO safeguard the neurovascular unit
Published in The Journal of experimental medicine (21-09-2015)“…Inactivating mutations of the NF-κB essential modulator (NEMO), a key component of NF-κB signaling, cause the genetic disease incontinentia pigmenti (IP). This…”
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Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts
Published in International journal of medical microbiology (01-10-2018)“…Staphylococcus aureus is the most frequent pathogen causing diabetic foot infections. Here, we investigated the degree of bacterial virulence required to…”
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5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human HV1 Channel
Published in Pharmaceuticals (Basel, Switzerland) (27-04-2023)“…5-chloro-2-guanidinobenzimidazole (ClGBI), a small-molecule guanidine derivative, is a known effective inhibitor of the voltage-gated proton (H+) channel (HV1,…”
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CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes
Published in The Journal of immunology (1950) (01-04-2012)“…Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic β cells. CD1d-restricted NKT lymphocytes have…”
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Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration
Published in Journal of cell science (01-08-2014)“…Here, we identify a role for the matrilin-2 (Matn2) extracellular matrix protein in controlling the early stages of myogenic differentiation. We observed Matn2…”
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The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
Published in Diabetes (New York, N.Y.) (01-02-2013)“…We provide the first comprehensive analysis of the extracellular matrix (ECM) composition of peri-islet capsules, composed of the peri-islet basement membrane…”
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Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus
Published in Molecular genetics and genomics : MGG (01-03-2007)“…Understanding the molecular mechanisms underlying bone development is a fundamental and fascinating problem in developmental biology, with significant medical…”
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Expression of matrilin-2 in oval cells during rat liver regeneration
Published in Matrix biology (01-09-2007)“…The matrilins represent a new family of oligomeric proteins that are assumed to act as adapter molecules connecting other proteins and proteoglycans in the…”
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Expression of Matrilin-2 in Liver Cirrhosis and Hepatocellular Carcinoma
Published in Pathology oncology research (01-03-2008)“…The recently described matrilin protein family is part of the extracellular matrix, their pathophysiological role as well as distribution in liver diseases,…”
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Expression of immunoregulatory tumor necrosis factor-like molecule TL1A in chicken chondrocyte differentiation
Published in Canadian journal of veterinary research (2009)“…The proinflammatory cytokine tumor necrosis factor (TNF) alpha is not encoded in the chicken genome. However, 1 member of the TNF family, TNF-like molecule 1A…”
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Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
Published in Science translational medicine (09-11-2016)“…The enzymes gelatinase A/matrix metalloproteinase-2 (MMP-2) and gelatinase B/MMP-9 are essential for induction of neuroinflammatory symptoms in experimental…”
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Identification of a Novel Structural Class of H V 1 Inhibitors by Structure-Based Virtual Screening
Published in Journal of chemical information and modeling (24-06-2024)“…The human voltage-gated proton channel, hH 1, is highly expressed in various cell types including macrophages, B lymphocytes, microglia, sperm cells and also…”
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Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow
Published in Matrix biology (01-04-2018)“…Hematopoietic stem and progenitor cell (HSPC) functions are regulated by a specialized microenvironment in the bone marrow - the hematopoietic stem cell niche…”
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