Search Results - "KORN, Klaus"

SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene by Ziegler, Katharina, Steininger, Philipp, Ziegler, Renate, Steinmann, Jörg, Korn, Klaus, Ensser, Armin

“…We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient…”
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Analysis of SARS-CoV-2 Spike Protein Variants with Recombinant Reporter Viruses Created from a Bacmid System by Cordsmeier, Arne, Jungnickl, Doris, Herrmann, Alexandra, Korn, Klaus, Ensser, Armin

“…SARS-CoV-2, the causative agent of COVID-19, has spread around the world with more than 700 million cases and 6.8 million deaths. Various variants of concern…”
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Results of Tick-Borne Encephalitis Virus (TBEV) Diagnostics in an Endemic Area in Southern Germany, 2007 to 2022 by Steininger, Philipp, Ensser, Armin, Knöll, Antje, Korn, Klaus

“…Tick-borne encephalitis virus (TBEV) is the most important tick-transmitted neurotropic flavivirus in Europe and Asia. Our analysis aimed to investigate the…”
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A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations by Hutterer, Corina, Eickhoff, Jan, Milbradt, Jens, Korn, Klaus, Zeitträger, Isabel, Bahsi, Hanife, Wagner, Sabrina, Zischinsky, Gunther, Wolf, Alexander, Degenhart, Carsten, Unger, Anke, Baumann, Matthias, Klebl, Bert, Marschall, Manfred

“…Protein kinases represent central and multifunctional regulators of a balanced virus-host interaction. Cyclin-dependent protein kinase 7 (CDK7) plays crucial…”
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Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay by Nagel, Angela, Dimitrakopoulou, Emmanouela, Teig, Norbert, Kern, Peter, Lücke, Thomas, Michna, Dariusz, Korn, Klaus, Steininger, Philipp, Shahada, Khalid, Neumann, Katrin, Überla, Klaus

“…The majority of congenital cytomegalovirus (cCMV) infections are asymptomatic at birth and therefore not diagnosed. Approximately 10-15% of these infants…”
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Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2 by Lapuente, Dennis, Maier, Clara, Irrgang, Pascal, Hübner, Julian, Peter, Antonia Sophia, Hoffmann, Markus, Ensser, Armin, Ziegler, Katharina, Winkler, Thomas H., Birkholz, Torsten, Kremer, Andreas E., Steininger, Philipp, Korn, Klaus, Neipel, Frank, Überla, Klaus, Tenbusch, Matthias

“…SARS-CoV-2 has emerged as a previously unknown zoonotic coronavirus that spread worldwide causing a serious pandemic. While reliable nucleic acid–based…”
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Transmission of Drug-Resistant HIV-1 Is Stabilizing in Europe by Vercauteren, Jurgen, Wensing, Annemarie M. J., van de Vijver, David A. M. C., Albert, Jan, Balotta, Claudia, Hamouda, Osamah, Kücherer, Claudia, Struck, Daniel, Schmit, Jean-Claude, Åsjö, Birgitta, Bruckova, Marie, Camacho, Ricardo J., Clotet, Bonaventura, Coughlan, Suzie, Grossman, Zehava, Horban, Andrzej, Korn, Klaus, Kostrikis, Leondios, Nielsen, Claus, Paraskevis, Dimitrios, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Riva, Chiara, Ruiz, Lidia, Salminen, Mika, Schuurman, Rob, Sonnerborg, Anders, Stanekova, Danica, Stanojevic, Maja, Vandamme, Anne-Mieke, Boucher, Charles A. B.

“…The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793…”
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Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018 by Elling, Roland, Böttcher, Sindy, du Bois, Florian, Müller, Alexandra, Prifert, Christiane, Weissbrich, Benedikt, Hofmann, Jörg, Korn, Klaus, Eis-Hübinger, Anna-Maria, Hufnagel, Markus, Panning, Marcus

“…In 2018, a cluster of pediatric human parechovirus (HPeV) infections in 2 neighboring German hospitals was detected. Viral protein 1 sequence analysis…”
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Definition of a New HLA B52-Restricted Rev CTL Epitope Targeted by an HIV-1-Infected Controller by El Kenz, Boutaina, Schmidt, Katja G, Ogungbemi-Alt, Victoria K, Bergmann, Silke, Steininger, Philipp, Korn, Klaus, Spriewald, Bernd, Harrer, Ellen G, Nganou-Makamdop, Krystelle, Harrer, Thomas

“…The analysis of T-cell responses in HIV-1-infected controllers may contribute to a better understanding of the protective components of the immune system…”
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Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020 by Wagner, Ralf, Peterhoff, David, Beileke, Stephanie, Günther, Felix, Berr, Melanie, Einhauser, Sebastian, Schütz, Anja, Niller, Hans Helmut, Steininger, Philipp, Knöll, Antje, Tenbusch, Matthias, Maier, Clara, Korn, Klaus, Stark, Klaus J., Gessner, André, Burkhardt, Ralph, Kabesch, Michael, Schedl, Holger, Küchenhoff, Helmut, Pfahlberg, Annette B., Heid, Iris M., Gefeller, Olaf, Überla, Klaus

“…SARS-CoV-2 infection fatality ratios (IFR) remain controversially discussed with implications for political measures. The German county of Tirschenreuth…”
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HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics by Abecasis, Ana B, Wensing, Annemarie M J, Paraskevis, Dimitris, Vercauteren, Jurgen, Theys, Kristof, Van de Vijver, David A M C, Albert, Jan, Asjö, Birgitta, Balotta, Claudia, Beshkov, Danail, Camacho, Ricardo J, Clotet, Bonaventura, De Gascun, Cillian, Griskevicius, Algis, Grossman, Zehava, Hamouda, Osamah, Horban, Andrzej, Kolupajeva, Tatjana, Korn, Klaus, Kostrikis, Leon G, Kücherer, Claudia, Liitsola, Kirsi, Linka, Marek, Nielsen, Claus, Otelea, Dan, Paredes, Roger, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Schmit, Jean-Claude, Sönnerborg, Anders, Stanekova, Danika, Stanojevic, Maja, Struck, Daniel, Boucher, Charles A B, Vandamme, Anne-Mieke

“…Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug…”
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Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing by Bartenhagen, Christoph, Fischer, Ute, Korn, Klaus, Pfister, Stefan M, Gombert, Michael, Chen, Cai, Okpanyi, Vera, Hauer, Julia, Rinaldi, Anna, Bourquin, Jean-Pierre, Eckert, Cornelia, Hu, Jianda, Ensser, Armin, Dugas, Martin, Borkhardt, Arndt

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Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County-Results from a Population-Based Longitudinal Study in Germany by Einhauser, Sebastian, Peterhoff, David, Beileke, Stephanie, Günther, Felix, Niller, Hans-Helmut, Steininger, Philipp, Knöll, Antje, Korn, Klaus, Berr, Melanie, Schütz, Anja, Wiegrebe, Simon, Stark, Klaus J, Gessner, André, Burkhardt, Ralph, Kabesch, Michael, Schedl, Holger, Küchenhoff, Helmut, Pfahlberg, Annette B, Heid, Iris M, Gefeller, Olaf, Überla, Klaus, Wagner, Ralf

“…Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which…”
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The N-Terminus of the HIV-1 p6 Gag Protein Regulates Susceptibility to Degradation by IDE by Schmalen, Adrian, Karius-Fischer, Julia, Rauch, Pia, Setz, Christian, Korn, Klaus, Henklein, Petra, Fossen, Torgils, Schubert, Ulrich

“…As part of the Pr55 polyprotein, p6 fulfills an essential role in the late steps of the replication cycle. However, almost nothing is known about the functions…”
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Patterns of transmitted HIV drug resistance in Europe vary by risk group by Frentz, Dineke, van de Vijver, David, Abecasis, Ana, Albert, Jan, Hamouda, Osamah, Jørgensen, Louise, Kücherer, Claudia, Struck, Daniel, Schmit, Jean-Claude, Vercauteren, Jurgen, Asjö, Birgitta, Balotta, Claudia, Bergin, Colm, Beshkov, Danail, Camacho, Ricardo, Clotet, Bonaventura, Griskevicius, Algirdas, Grossman, Zehava, Horban, Andrzej, Kolupajeva, Tatjana, Korn, Klaus, Kostrikis, Leondios, Linka, Kirsi Liitsola Marek, Nielsen, Claus, Otelea, Dan, Paraskevis, Dimitrios, Paredes, Roger, Poljak, Mario, Puchhammer-Stöckl, Elisabeth, Sönnerborg, Anders, Stanekova, Danica, Stanojevic, Maja, Vandamme, Anne-Mieke, Boucher, Charles, Wensing, Annemarie

“…In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted…”
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Single-Point Mutations Causing More than 100-Fold Underestimation of Human Immunodeficiency Virus Type 1 (HIV-1) Load with the Cobas TaqMan HIV-1 Real-Time PCR Assay by Korn, Klaus, Weissbrich, Benedikt, Henke-Gendo, Cornelia, Heim, Albert, Jauer, Christin Mariel, Taylor, Ninon, Eberle, Josef

“…Systematic sequence analysis of human immunodeficiency virus type 1 (HIV-1) variants with RNA levels underestimated by the Cobas TaqMan HIV-1 assay…”
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Fatal Puumala Hantavirus Infection in a Patient with Common Variable Immunodeficiency (CVID) by Steininger, Philipp, Herbst, Larissa, Bihlmaier, Karl, Willam, Carsten, Körper, Sixten, Schrezenmeier, Hubert, Klüter, Harald, Pfister, Frederick, Amann, Kerstin, Weiss, Sabrina, Krüger, Detlev H, Zimmermann, Robert, Korn, Klaus, Hofmann, Jörg, Harrer, Thomas

“…Puumala hantavirus (PUUV) infections usually show a mild or moderate clinical course, but may sometimes also lead to life-threatening disease. Here, we report…”
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Diversity and Complexity of HIV-1 Drug Resistance: A Bioinformatics Approach to Predicting Phenotype from Genotype by Beerenwinkel, Niko, Schmidt, Barbara, Walter, Hauke, Kaiser, Rolf, Lengauer, Thomas, Hoffmann, Daniel, Korn, Klaus, Selbig, Joachim

“…Drug resistance testing has been shown to be beneficial for clinical management of HIV type 1 infected patients. Whereas phenotypic assays directly measure…”
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Prevalence of key resistance mutations K65R, K103N, and M184V as minority HIV-1 variants in chronically HIV-1 infected, treatment-naïve patients by Metzner, Karin J, Rauch, Pia, Braun, Patrick, Knechten, Heribert, Ehret, Robert, Korn, Klaus, Kaiser, Rolf, Sichtig, Nadine, Ranneberg, Britta, van Lunzen, Jan, Walter, Hauke

“…Abstract Background and objectives Minority drug-resistant HIV-1 variants, undetected by conventional genotyping, may impair the outcome of antiretroviral…”
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Variability of high risk HPV genotypes among HIV infected women in Mwanza, Tanzania- the need for evaluation of current vaccine effectiveness in developing countries by Mujuni, Fridolin, Mirambo, Mariam M, Rambau, Peter, Klaus, Korn, Andreas, Muller, Matovelo, Dismas, Majigo, Mtebe, Kasang, Christa, Mshana, Stephen E

“…High risk (HR) human papilloma Virus (HPV) genotypes have been associated with cervical cancer. In Tanzania there is a limited data on the epidemiology of HPV…”
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