Search Results - "KORIAZOVA, Lilia"

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism by Ptacin, Jerod L., Caffaro, Carolina E., Ma, Lina, San Jose Gall, Kristine M., Aerni, Hans R., Acuff, Nicole V., Herman, Rob W., Pavlova, Yelena, Pena, Michael J., Chen, David B., Koriazova, Lilia K., Shawver, Laura K., Joseph, Ingrid B., Milla, Marcos E.

“…The implementation of applied engineering principles to create synthetic biological systems promises to revolutionize medicine, but application of…”
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Translocation of botulinum neurotoxin light chain protease through the heavy chain channel by Montal, Mauricio, Koriazova, Lilia K

“…Clostridial botulinum neurotoxins (BoNTs) abort the process of neurotransmitter release at presynaptic motor nerve terminals, causing muscle paralysis. An…”
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Vaccinia Virus Extracellular Enveloped Virion Neutralization In Vitro and Protection In Vivo Depend on Complement by MOHAMMED RAFII-EL-IDRISSI BENHNIA, MCCAUSLAND, Megan M, MOYRON, Juan, LAUDENSLAGER, John, GRANGER, Steven, RICKERT, Sandra, KORIAZOVA, Lilia, KUBO, Ralph, KATO, Shinichiro, CROTTY, Shane

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A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism by Ptacin, Jerod L., Ma, Lina, Caffaro, Carolina E., Acuff, Nicole V., Germar, Kristine, Severy, Peter, Qu, Yanyan, Vela, Jose-Luis, Cai, Xinming, San Jose, Kristine M., Aerni, Hans R., Chen, David B., Esche, Ean, Ismaili, Taylor K., Herman, Rob, Pavlova, Yelena, Pena, Michael J., Nguyen, Jasmine, Koriazova, Lilia K., Shawver, Laura K., Joseph, Ingrid B., Mooney, Jill, Peakman, Mark, Milla, Marcos E.

“…Background Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK)…”
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Protection of rabbits and immunodeficient mice against lethal poxvirus infections by human monoclonal antibodies by Crickard, Lindsay, Babas, Tahar, Seth, Sidharth, Silvera, Peter, Koriazova, Lilia, Crotty, Shane

“…Smallpox (variola virus) is a bioweapon concern. Monkeypox is a growing zoonotic poxvirus threat. These problems have resulted in extensive efforts to develop…”
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Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae by Kristian, Sascha A, Ota, Takayuki, Bubeck, Sarah S, Cho, Rebecca, Groff, Brian C, Kubota, Tsuguo, Destito, Giuseppe, Martin, Cécile, Laudenslager, John, Koriazova, Lilia, Tahara, Tomoyuki, Kanda, Yutaka

“…A proof-of-concept study evaluating the potential of Streptococcus pneumoniae Pneumococcal Surface Protein A (PspA) as a passive immunization target was…”
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A Precision Engineered Interleukin-2 for Bolstering CD8+ T- and NK-cell Activity without Eosinophilia and Vascular Leak Syndrome in Nonhuman Primates by Ma, Lina, Acuff, Nicole V., Joseph, Ingrid B., Ptacin, Jerod L., Caffaro, Carolina E., San Jose, Kristine M., Aerni, Hans R., Carrio, Roberto, Byers, Anthony M., Herman, Rob W., Pavlova, Yelena, Pena, Michael J., Chen, David B., Buetz, Christen, Ismaili, Taylor K., Pham, Helene V., Cucchetti, Margot, Sassoon, Ingrid, Koriazova, Lilia K., Leveque, Joseph A., Shawver, Laura K., Mooney, Jill M., Milla, Marcos E.

“…We have created a precisely pegylated IL-2 [SAR-444245 (SAR'245) or pegenzileukin, previously THOR-707] designed for proliferation of target CD8+ T and NK…”
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Correction: Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae by Kristian, Sascha A, Ota, Takayuki, Bubeck, Sarah S, Cho, Rebecca, Groff, Brian C, Kubota, Tsuguo, Destito, Giuseppe, Martin, Cécile, Laudenslager, John, Koriazova, Lilia, Tahara, Tomoyuki, Kanda, Yutaka

“…[This corrects the article DOI: 10.1371/journal.pone.0154616.]…”
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Unusual Features of Vaccinia Virus Extracellular Virion Form Neutralization Resistance Revealed in Human Antibody Responses to the Smallpox Vaccine by Benhnia, Mohammed Rafii-El-Idrissi, Maybeno, Matthew, Blum, David, Aguilar-Sino, Rowena, Matho, Michael, Meng, Xiangzhi, Head, Steven, Felgner, Philip L, Zajonc, Dirk M, Koriazova, Lilia, Kato, Shinichiro, Burton, Dennis R, Xiang, Yan, Crowe, Jr, James E, Peters, Bjoern, Crotty, Shane

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Heavily Isotype-Dependent Protective Activities of Human Antibodies against Vaccinia Virus Extracellular Virion Antigen B5 by RAFII-EL-IDRISSI BENHNIA, Mohammed, MCCAUSLAND, Megan M, LAUDENSLAGER, John, GRANGER, Steven W, RICKERT, Sandra, KORIAZOVA, Lilia, TAHARA, Tomoyuki, KUBO, Ralph T, KATO, Shinichiro, CROTTY, Shane

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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THOR-707: Using synthetic biology to reprogram the therapeutic activity of interleukin-2 (IL-2) by Milla, Marcos E, Ptacin, Jerod, Caffaro, Carolina E., Aerni, Hans R., Ma, Lina, Koriazova, Lilia, Joseph, Ingrid B., Shawver, Laura K.

“…Abstract only 2603 Background: Recombinant interleukin-2 (rIL-2; aldesleukin) is an approved immunotherapy in melanoma and renal cell carcinoma based on…”
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Abstract 3258: THOR-707, a novel not-alpha IL-2, elicits durable pharmacodynamic responses in non-human primates and efficacy as single agent and in combination with anti PD-1 in multiple syngeneic mouse models by Joseph, Ingrid B., Ma, Lina, Ptacin, Jerod L., Caffaro, Carolina E., Aerni, Hans R., Jose, Kristine M. San, Pena, Michael J., Herman, Robert W., Pavlova, Yelena, Chen, David B., Bragstad, Ken, Li, Shukuan, Nguyen, Jasmine, Shawver, Laura K., Koriazova, Lilia K., Milla, Marcos E.

“…Aldesleukin is a recombinant form of IL-2 approved for metastatic melanoma and renal cell carcinoma that induced complete, durable remissions in certain…”
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A precision engineered interleukin-2 (IL-2) for bolstering CD8+ T- and NK-cell activity without eosinophilia and vascular leak syndrome in non-human primates by Ma, Lina, Acuff, Nicole V, Joseph, Ingrid B, Ptacin, Jerod L, Caffaro, Carolina E, San Jose, Kristine M, Aerni, Hans R, Carrio, Roberto, Byers, Anthony M, Herman, Rob W, Pavlova, Yelena, Pena, Michael J, Chen, David B, Buetz, Christen, Ismaili, Taylor K, Pham, Helene V, Cucchetti, Margot, Sassoon, Ingrid, Koriazova, Lilia K, Leveque, Joseph A, Shawver, Laura K, Mooney, Jill M, Milla, Marcos E

“…We have created a precisely pegylated IL-2 [SAR-444245 (SAR'245) or pegenzileukin, previously THOR- 707] designed for proliferation of target CD8+ T and NK…”
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Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein by Wang, Rongfang, Song, Aihua, Levin, James, Dennis, Dawna, Zhang, Noelle J., Yoshida, Hitoshi, Koriazova, Lilia, Madura, Lydia, Shapiro, Laura, Matsumoto, Atsushi, Yoshida, Hideaki, Mikayama, Toshifumi, Kubo, Ralph T., Sarawar, Sally, Cheroutre, Hilde, Kato, Shinichiro

“…Influenza is one of the most prevalent viral diseases in humans. For some high-risk human populations, including the infant, the elderly, and the…”
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Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model by McCausland, Megan M, Benhnia, Mohammed Rafii-El-Idrissi, Crickard, Lindsay, Laudenslager, John, Granger, Steven W, Tahara, Tomoyuki, Kubo, Ralph, Koriazova, Lilia, Kato, Shinichiro, Crotty, Shane

“…Treatment of rare severe side effects of vaccinia virus (VACV) immunization in humans is currently very challenging. VACV possesses two immunologically…”
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Protective murine and human monoclonal antibodies against eczema vaccinatum by Tomimori, Yoshiaki, Kawakami, Yuko, McCausland, Megan M, Ando, Tomoaki, Koriazova, Lilia, Kato, Shinichiro, Kawakami, Toshiaki, Crotty, Shane

“…Eczema vaccinatum is the most common severe pathology associated with smallpox vaccination (vaccinia virus), occurring at high rates among individuals with a…”
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Tight correlation between inhibition of DNA repair in vitro and transcription factor IIIA binding in a 5S ribosomal RNA gene by Conconi, Antonio, Liu, Xiaoqi, Koriazova, Lilia, Ackerman, Eric J., Smerdon, Michael J.

“…UV‐induced photoproducts (cyclobutane pyrimidine dimers, CPDs) in DNA are removed by nucleotide excision repair (NER), and the presence of transcription…”
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Tight correlation between inhibition of DNA repair in vitroand transcription factor IIIA binding in a 5S ribosomal RNA gene by Conconi, Antonio, Liu, Xiaoqi, Koriazova, Lilia, Ackerman, Eric J, Smerdon, Michael J

“…UV-induced photoproducts (cyclobutane pyrimidine dimers, CPDs) in DNA are removed by nucleotide excision repair (NER), and the presence of transcription…”
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