Search Results - "KORFHAGEN, Thomas R"

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation by Rajavelu, Priya, Chen, Gang, Xu, Yan, Kitzmiller, Joseph A, Korfhagen, Thomas R, Whitsett, Jeffrey A

“…Epithelial cells that line the conducting airways provide the initial barrier and innate immune responses to the abundant particles, microbes, and allergens…”
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Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma by Le Cras, Timothy D, Acciani, Thomas H, Mushaben, Elizabeth M, Kramer, Elizabeth L, Pastura, Patricia A, Hardie, William D, Korfhagen, Thomas R, Sivaprasad, Umasundari, Ericksen, Mark, Gibson, Aaron M, Holtzman, Michael J, Whitsett, Jeffrey A, Hershey, Gurjit K Khurana

“…Increases in the epidermal growth factor receptor (EGFR) have been associated with the severity of airway thickening in chronic asthmatic subjects, and EGFR…”
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SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia by Korfhagen, Thomas R, Kitzmiller, Joseph, Chen, Gang, Sridharan, Anusha, Haitchi, Hans-Michael, Hegde, Rashmi S, Divanovic, Senad, Karp, Christopher L, Whitsett, Jeffrey A

“…Airway mucus plays a critical role in clearing inhaled toxins, particles, and pathogens. Diverse toxic, inflammatory, and infectious insults induce airway…”
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Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice by Glasser, Stephan W, Maxfield, Melissa D, Ruetschilling, Teah L, Akinbi, Henry T, Baatz, John E, Kitzmiller, Joseph A, Page, Kristen, Xu, Yan, Bao, Erik L, Korfhagen, Thomas R

“…Pulmonary surfactant protein-C (SP-C) gene-targeted mice (Sftpc(-/-)) develop progressive lung inflammation and remodeling. We hypothesized that SP-C…”
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Signaling pathways in the epithelial origins of pulmonary fibrosis by Hardie, William D., Hagood, James S., Dave, Vrushank, Perl, Anne-Karina T., Whitsett, Jeffrey A., Korfhagen, Thomas R., Glasser, Stephan

“…Pulmonary fibrosis complicates a number of disease processes and leads to substantial morbidity and mortality. Idiopathic pulmonary fibrosis (IPF) is perhaps…”
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Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis by Madala, Satish K, Edukulla, Ramakrishna, Phatak, Mukta, Schmidt, Stephanie, Davidson, Cynthia, Acciani, Thomas H, Korfhagen, Thomas R, Medvedovic, Mario, Lecras, Timothy D, Wagner, Kimberly, Hardie, William D

“…Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic lesions in the lung, which progress to impair gas exchange…”
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Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production by Deshmukh, Hitesh S, Shaver, Colleen, Case, Lisa M, Dietsch, Maggie, Wesselkamper, Scott C, Hardie, William D, Korfhagen, Thomas R, Corradi, Massimo, Nadel, Jay A, Borchers, Michael T, Leikauf, George D

“…Chronic obstructive pulmonary disease (COPD), a global public health problem, is characterized by progressive difficulty in breathing, with increased mucin…”
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Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection by Glasser, Stephan W, Witt, Teah L, Senft, Albert P, Baatz, John E, Folger, Dusti, Maxfield, Melissa D, Akinbi, Henry T, Newton, Danforth A, Prows, Daniel R, Korfhagen, Thomas R

“…Patients with mutations in the pulmonary surfactant protein C (SP-C) gene develop interstitial lung disease and pulmonary exacerbations associated with viral…”
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Macrophage Dysfunction and Susceptibility to Pulmonary Pseudomonas aeruginosa Infection in Surfactant Protein C-Deficient Mice by Glasser, Stephan W, Senft, Albert P, Whitsett, Jeffrey A, Maxfield, Melissa D, Ross, Gary F, Richardson, Theresa R, Prows, Daniel R, Xu, Yan, Korfhagen, Thomas R

“…To determine the role of surfactant protein C (SP-C) in host defense, SP-C-deficient (Sftpc-/-) mice were infected with the pulmonary pathogen Pseudomonas…”
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Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo by LeVine, Ann Marie, Whitsett, Jeffrey A, Hartshorn, Kevan L, Crouch, Erika C, Korfhagen, Thomas R

“…Mice lacking surfactant protein surfactant protein D (SP-D(-/-)) and wild-type mice (SP-D(+/+)) were infected with influenza A virus (IAV) by intranasal…”
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Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis by Madala, Satish K, Edukulla, Ramakrishna, Davis, Katy R, Schmidt, Stephanie, Davidson, Cynthia, Kitzmiller, Joseph A, Hardie, William D, Korfhagen, Thomas R

“…Background Resistin-like molecule alpha or found in inflammatory zone protein (Fizz1) is increased in pulmonary epithelial cells and also in limited amounts by…”
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Altered Stability of Pulmonary Surfactant in SP-C-Deficient Mice by Glasser, Stephan W., Burhans, Michael S., Korfhagen, Thomas R., Na, Cheng-Lun, Sly, Peter D., Ross, Gary F., Ikegami, Machiko, Whitsett, Jeffrey A.

“…The surfactant protein C (SP-C) gene encodes an extremely hydrophobic, 4-kDa peptide produced by alveolar epithelial cells in the lung. To discern the role of…”
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Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung by LeVine, Ann Marie, Whitsett, Jeffrey A, Gwozdz, Jodie A, Richardson, Theresa R, Fisher, James H, Burhans, Michael S, Korfhagen, Thomas R

“…Mice lacking surfactant protein (SP)-A (SP-A-/-) or SP-D (SP-D-/-) and wild-type mice were infected with group B streptococcus or Haemophilus influenzae by…”
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Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells by Ikegami, Machiko, Na, Cheng-Lun, Korfhagen, Thomas R, Whitsett, Jeffrey A

“…Surfactant protein D (SP-D) is a member of the collectin family of the innate host defense proteins. In the lung, SP-D is expressed primarily by type II cells…”
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Early Growth Response-1 Suppresses Epidermal Growth Factor Receptor-Mediated Airway Hyperresponsiveness and Lung Remodeling in Mice by Kramer, Elizabeth L, Mushaben, Elizabeth M, Pastura, Patricia A, Acciani, Thomas H, Deutsch, Gail H, Khurana Hershey, Gurjit K, Korfhagen, Thomas R, Hardie, William D, Whitsett, Jeffrey A, Le Cras, Timothy D

“…Transforming growth factor (TGF)-alpha and its receptor, the epidermal growth factor receptor, are induced after lung injury and are associated with remodeling…”
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Endothelial immune activation programmes cell‐fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4‐ERK‐FOXC2 signalling by Xia, Sheng, Menden, Heather L., Korfhagen, Thomas R., Kume, Tsutomu, Sampath, Venkatesh

“…Key points The mechanisms by which bacteria alter endothelial cell phenotypes and programme inflammatory angiogenesis remain unclear. In lung endothelial…”
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Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo by Borron, P, McIntosh, J C, Korfhagen, T R, Whitsett, J A, Taylor, J, Wright, J R

“…The role of surfactant-associated protein (SP) A in the mediation of pulmonary responses to bacterial lipopolysaccharide (LPS) was assessed in vivo with SP-A…”
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SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production by Chen, Gang, Korfhagen, Thomas R, Xu, Yan, Kitzmiller, Joseph, Wert, Susan E, Maeda, Yutaka, Gregorieff, Alexander, Clevers, Hans, Whitsett, Jeffrey A

“…Various acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and…”
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Surfactant Protein-D Regulates Soluble CD14 through Matrix Metalloproteinase-12 by Senft, Albert P, Korfhagen, Thomas R, Whitsett, Jeffrey A, Shapiro, Steven D, LeVine, Ann Marie

“…Surfactant protein D (SP-D) and CD14 are important innate immune defense molecules that mediate clearance of pathogens and apoptotic cells from the lung. To…”
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Foxa3 Induces Goblet Cell Metaplasia and Inhibits Innate Antiviral Immunity by GANG CHEN, KORFHAGEN, Thomas R, SENFT, Albert P, WHITSETT, Jeffrey A, KARP, Christopher L, IMPEY, Soren, YAN XU, RANDELL, Scott H, KITZMILLER, Joseph, MAEDA, Yutaka, HAITCHI, Hans Michael, SRIDHARAN, Anusha

“…Goblet cell metaplasia accompanies common pulmonary disorders that are prone to recurrent viral infections. Mechanisms regulating both goblet cell metaplasia…”
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