Search Results - "KORBMACHER, Christoph"

Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC) by Loffing, Johannes, Korbmacher, Christoph

“…The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule 2, the connecting tubule (CNT) and the collecting duct. The…”
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Effects of syntaxins 2, 3, and 4 on rat and human epithelial sodium channel (ENaC) in Xenopus laevis oocytes by Rauh, Robert, Frost, Fabian, Korbmacher, Christoph

“…Syntaxins are SNARE proteins and may play a role in epithelial sodium channel (ENaC) trafficking. The aim of the present study was to investigate the effects…”
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Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology by Pearce, David, Manis, Anna D., Nesterov, Viatcheslav, Korbmacher, Christoph

“…Regulated Na + transport in the distal nephron is of fundamental importance to fluid and electrolyte homeostasis. Further upstream, Na + is the principal…”
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Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis by Ilyaskin, Alexandr V., Korbmacher, Christoph, Diakov, Alexei

“…Mice lacking connexin 30 (Cx30) display increased epithelial sodium channel (ENaC) activity in the distal nephron and develop salt-sensitive hypertension. This…”
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Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain by Zhao, Peishen, Lieu, TinaMarie, Barlow, Nicholas, Sostegni, Silvia, Haerteis, Silke, Korbmacher, Christoph, Liedtke, Wolfgang, Jimenez-Vargas, Nestor N., Vanner, Stephen J., Bunnett, Nigel W.

“…Proteases that cleave protease-activated receptor-2 (PAR2) at Arg36↓Ser37 reveal a tethered ligand that binds to the cleaved receptor. PAR2 activates transient…”
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The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice by Lieu, TinaMarie, Jayaweera, Gihan, Zhao, Peishen, Poole, Daniel P, Jensen, Dane, Grace, Megan, McIntyre, Peter, Bron, Romke, Wilson, Yvette M, Krappitz, Matteus, Haerteis, Silke, Korbmacher, Christoph, Steinhoff, Martin S, Nassini, Romina, Materazzi, Serena, Geppetti, Pierangelo, Corvera, Carlos U, Bunnett, Nigel W

“…Background & Aims Patients with cholestatic disease have increased systemic concentrations of bile acids (BAs) and profound pruritus. The G-protein–coupled BA…”
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Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome by Bohnert, Bernhard N, Menacher, Martina, Janessa, Andrea, Wörn, Matthias, Schork, Anja, Daiminger, Sophie, Kalbacher, Hubert, Häring, Hans-Ulrich, Daniel, Christoph, Amann, Kerstin, Sure, Florian, Bertog, Marko, Haerteis, Silke, Korbmacher, Christoph, Artunc, Ferruh

“…Volume retention in nephrotic syndrome has been linked to activation of the epithelial sodium channel (ENaC) by proteolysis of its γ-subunit following urinary…”
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Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels by Keely, Stephen J, Urso, Andreacarola, Ilyaskin, Alexandr V, Korbmacher, Christoph, Bunnett, Nigel W, Poole, Daniel P, Carbone, Simona E

“…Bile acids (BAs) are known to be important regulators of intestinal motility and epithelial fluid and electrolyte transport. Over the past two decades,…”
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Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron by Nesterov, Viatcheslav, Dahlmann, Anke, Krueger, Bettina, Bertog, Marko, Loffing, Johannes, Korbmacher, Christoph

“…Aldosterone is thought to be the main hormone to stimulate the epithelial sodium channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) comprising…”
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Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice by Artunc, Ferruh, Bohnert, Bernhard N., Schneider, Jonas C., Staudner, Tobias, Sure, Florian, Ilyaskin, Alexandr V., Wörn, Matthias, Essigke, Daniel, Janessa, Andrea, Nielsen, Nis V., Birkenfeld, Andreas L., Etscheid, Michael, Haerteis, Silke, Korbmacher, Christoph, Kanse, Sandip M.

“…Proteolytic activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases is thought to contribute to renal sodium retention in…”
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Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel by SVENNINGSEN, Per, BISTRUP, Claus, JESPERSEN, Bente, JENSEN, Boye L, KORBMACHER, Christoph, SKØTT, Ole, FRIIS, Ulla G, BERTOG, Marko, HAERTEIS, Silke, KRUEGER, Bettina, STUBBE, Jane, JENSEN, Ole Nørregaard, THIESSON, Helle C, UHRENHOLT, Torben R

“…Proteinuria and increased renal reabsorption of NaCl characterize the nephrotic syndrome. Here, we show that protein-rich urine from nephrotic rats and from…”
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mTORC2 critically regulates renal potassium handling by Grahammer, Florian, Nesterov, Viatcheslav, Ahmed, Azaz, Steinhardt, Frederic, Sandner, Lukas, Arnold, Frederic, Cordts, Tomke, Negrea, Silvio, Bertog, Marko, Ruegg, Marcus A, Hall, Michael N, Walz, Gerd, Korbmacher, Christoph, Artunc, Ferruh, Huber, Tobias B

“…The mTOR pathway orchestrates cellular homeostasis. The rapamycin-sensitive mTOR complex (mTORC1) in the kidney has been widely studied; however, mTORC2…”
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Atomic Force Microscopy Reveals the Architecture of the Epithelial Sodium Channel (ENaC) by Stewart, Andrew P., Haerteis, Silke, Diakov, Alexei, Korbmacher, Christoph, Edwardson, J. Michael

“…The epithelial sodium channel (ENaC) is a member of the ENaC/degenerin superfamily. ENaC is a heteromultimer containing three homologous subunits (α, β, and…”
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Trypsin can activate the epithelial sodium channel (ENaC) in microdissected mouse distal nephron by Nesterov, Viatcheslav, Dahlmann, Anke, Bertog, Marko, Korbmacher, Christoph

“…Proteases are involved in the processing and activation of the epithelial sodium channel (ENaC). The aim of the present study was to investigate whether the…”
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Proteolytic activation of the epithelial sodium channel (ENaC) in health and disease by Korbmacher, Christoph

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Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC) by Lefèvre, Cathérine M. T., Diakov, Alexei, Haerteis, Silke, Korbmacher, Christoph, Gründer, Stefan, Wiemuth, Dominik

“…The human bile acid-sensitive ion channel (hBASIC) is a cation channel of the degenerin/epithelial Na + channel gene family that is expressed in the intestinal…”
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Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome by Bertog, Marko, Cuffe, John E., Pradervand, Sylvain, Hummler, Edith, Hartner, Andrea, Porst, Markus, Hilgers, Karl F., Rossier, Bernard C., Korbmacher, Christoph

“…Liddle's syndrome is an autosomal dominant form of human hypertension, caused by gain-of-function mutations of the epithelial sodium channel (ENaC) which is…”
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Additional Disruption of the ClC-2 Cl- Channel Does Not Exacerbate the Cystic Fibrosis Phenotype of Cystic Fibrosis Transmembrane Conductance Regulator Mouse Models by Zdebik, Anselm A, Cuffe, John E, Bertog, Marko, Korbmacher, Christoph, Jentsch, Thomas J

“…Cystic fibrosis is a fatal inherited disease that is caused by mutations in the gene encoding a cAMP-activated chloride channel, the cystic fibrosis…”
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The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1 by YUN, C. Chris, PALMADA, Monica, KORBMACHER, Christoph, COHEN, Philip, PEARCE, David, LANG, Florian, EMBARK, Hamdy M, FEDORENKO, Olga, YUXI FENG, HENKE, Guido, SETIAWAN, Iwan, BOEHMER, Christoph, WEINMAN, Edward J, SANDRASAGRA, Sabrina

“…Mineralocorticoids stimulate Na(+) reabsorption and K(+) secretion in principal cells of connecting tubule and collecting duct. The involved ion channels are…”
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(NDRG2) Stimulates Amiloride-sensitive Na+ Currents in Xenopus laevis Oocytes and Fisher Rat Thyroid Cells by Wielpütz, Mark O., Lee, Il-Ha, Dinudom, Anuwat, Boulkroun, Sheerazed, Farman, Nicolette, Cook, David I., Korbmacher, Christoph, Rauh, Robert

“…Regulation of the epithelial sodium channel (ENaC) is highly complex and may involve several aldosterone-induced regulatory proteins. The N-Myc…”
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