Search Results - "KORACH, K. S"

Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β by Couse, J. F., Hewitt, S. Curtis, Bunch, D. O., Sar, M., Walker, V. R., Davis, B. J., Korach, K. S.

“…Mice lacking estrogen receptors α and β were generated to clarify the roles of each receptor in the physiology of estrogen target tissues. Both sexes of αβ…”
Get full text

A role for oestrogens in the male reproductive system by Hess, Rex A, Bunick, David, Lee, Ki-Ho, Bahr, Janice, Taylor, Julia A, Korach, Kenneth S, Lubahn, Dennis B

“…Oestrogen is considered to be the 'female' hormone, whereas testosterone is considered the 'male' hormone. However, both hormones are present in both sexes…”
Get full text

Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis by Yue, W, Santen, R.J, Wang, J.-P, Li, Y, Verderame, M.F, Bocchinfuso, W.P, Korach, K.S, Devanesan, P, Todorovic, R, Rogan, E.G, Cavalieri, E.L

“…Long term exposure to estradiol increases the risk of breast cancer in a variety of animal species, as well as in women. The mechanisms responsible for this…”
Get full text

The AF-1 Activation-Function of ERα May Be Dispensable to Mediate the Effect of Estradiol on Endothelial NO Production in Mice by Pendaries, C., Darblade, B., Rochaix, P., Krust, A., Chambon, P., Korach, K. S., Bayard, F., J.-F. Arnal

“…Two isoforms of estrogen receptor (ER) have been described: ERα and ERβ. The initial gene targeting of ERα, consisting in the introduction of a Neo cassette in…”
Get full text

Stromal Estrogen Receptors Mediate Mitogenic Effects of Estradiol on Uterine Epithelium by Cooke, P. S., Buchanan, D. L., Young, P., Setiawan, T., Brody, J., Korach, K. S., Taylor, J., Lubahn, D. B., Cunha, G. R.

“…Estradiol-17 β (E2) acts through the estrogen receptor (ER) to regulate uterine growth and functional differentiation. To determine whether E2 elicits…”
Get full text

Involvement of estrogen receptor α, β and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice by Choleris, E., Ogawa, S., Kavaliers, M., Gustafsson, J.‐Å., Korach, K. S., Muglia, L. J., Pfaff, D. W.

“…Social recognition, processing, and retaining information about conspecific individuals is crucial for the development of normal social relationships. The…”
Get full text

Genetic Contributions to Generalized Arousal of Brain and Behavior by Garey, J., Goodwillie, A., Frohlich, J., Morgan, M., J. -A. Gustafsson, Smithies, O., Korach, K. S., Ogawa, S., Pfaff, D. W.

“…We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators,…”
Get full text

Alteration of Reproductive Function but Not Prenatal Sexual Development After Insertional Disruption of the Mouse Estrogen Receptor Gene by Lubahn, Dennis B., Moyer, Jeffrey S., Golding, Thomas S., Couse, John F., Korach, Kenneth S., Smithies, Oliver

“…Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival, fertility, and female sexual differentiation and development…”
Get full text

Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency by Carani, Cesare, Qin, Kenan, Simoni, Manuela, Faustini-Fustini, Marco, Serpente, Stefania, Boyd, Jeff, Korach, Kenneth S, Simpson, Evan R

“…Recent reports of disruptive mutations of the genes for the estrogen receptor or for cytochrome P-450 aromatase 1 – 6 have shed new light on the role of…”
Get full text

Differential distribution of estrogen receptor (ER)-α and ER-β in the midbrain raphe nuclei and periaqueductal gray in male mouse: Predominant role of ER-β in midbrain serotonergic systems by Nomura, M., Akama, K.T., Alves, S.E., Korach, K.S., Gustafsson, J.-Å., Pfaff, D.W., Ogawa, S.

“…We examined the distribution of estrogen receptor (ER)-α and ER-β immunoreactive (ir) cells in the dorsal (DRN) and median/paramedian (MPRN) raphe nuclei in…”
Get full text

Estrogen Receptor-Dependent Sexual Differentiation of Dopaminergic Neurons in the Preoptic Region of the Mouse by Simerly, R. B., Zee, M. C., Pendleton, J. W., Lubahn, D. B., Korach, K. S.

“…Although it has been known for some time that estrogen exerts a profound influence on brain development a definitive demonstration of the role of the classical…”
Get full text

Different Regulatory Pathways of Endometrial Connexin Expression: Preimplantation Hormonal-Mediated Pathway Versus Embryo Implantation-Initiated Pathway by GRÜMMER, R, HEWITT, S. W, TRAUB, O, KORACH, K. S, WINTERHAGER, E

“…Transformation of the endometrium into the receptive phase is under the control of ovarian steroid hormones and is modulated by embryonic signals during…”
Get full text

Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice by Hart-Unger, S, Arao, Y, Hamilton, K J, Lierz, S L, Malarkey, D E, Hewitt, S C, Freemark, M, Korach, K S

“…Background: Treatment with estrogen in early menopausal women protects against development of hepatic steatosis and nonalcoholic fatty liver disease but…”
Get full text

Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse by Kos, M, Denger, S, Reid, G, Korach, KS, Gannon, F

“…The mouse knockout of the estrogen receptor alpha (ERalpha) gene, known as alphaERKO, has been extensively used for several years to study the role and…”
Get full text

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man by Smith, Eric P, Boyd, Jeff, Frank, Graeme R, Takahashi, Hiroyuki, Cohen, Robert M, Specker, Bonny, Williams, Timothy C, Lubahn, Dennis B, Korach, Kenneth S

“…The actions of adrenal and gonadal steroids, thyroid hormone, and vitamin D are mediated by receptors encoded by a family of related genes. Mutations of…”
Get full text

17β-Estradiol Induces Apoptosis in the Developing Rodent Prostate Independently of ERα or ERβ by Taylor, R. A, Cowin, P, Couse, J. F, Korach, K. S, Risbridger, G. P

“…Estrogens induce both proliferative and antiproliferative responses in the prostate gland. To date, antiproliferative effects of estrogens are generally…”
Get full text

Estrogen Inhibits the Vascular Injury Response in Estrogen Receptor β -Deficient Female Mice by Karas, Richard H., Hodgin, Jeffrey B., Kwoun, Moon, Krege, John H., Aronovitz, Mark, Mackey, William, Gustafsson, Jan Ake, Korach, Kenneth S., Smithies, Oliver, Mendelsohn, Michael E.

“…The protective effects of estrogen in the cardiovascular system result from both systemic effects and direct actions of the hormone on the vasculature. Two…”
Get full text

Expression of Estrogen Receptor β Is Developmentally Regulated in Reproductive Tissues of Male and Female Mice by Jefferson, Wendy N, Couse, John F, Banks, Elizabeth Padilla, Korach, Kenneth S, Newbold, Retha R

“…By the use of ribonuclease protection assay (RPA) combined with immunohistochemical techniques, the expression of estrogen receptor (ER) α and ERβ was mapped…”
Get full text

Spermatogenic cells do not require estrogen receptor-alpha for development or function by Mahato, D, Goulding, E H, Korach, K S, Eddy, E M

“…Estrogen receptors alpha (ERalpha) and beta (ERbeta) are ligand-dependent transcription factors and members of the nuclear hormone receptor superfamily encoded…”
Get full text

Estrogen receptor knockout mice: phenotypes in the female reproductive tract by EMMEN, J. M. A, KORACH, K. S

“…There is a broad spectrum of organ systems that respond to estrogen hormones, including the female and male reproductive tracts, mammary gland, the skeleton,…”
Get full text