Search Results - "KOPTA, L. A"

Pyrimidine Thioethers:  A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV by Nugent, Richard A, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Poel, Toni J, Wishka, Donn G, Graber, David R, Yagi, Yoshihiko, Keiser, Barbara J, Olmsted, Robert A, Kopta, Laurie A, Swaney, Steven M, Poppe, Susan M, Morris, Joel, Tarpley, W. Gary, Thomas, Richard C

“…A series of pyrimidine thioethers was synthesized and evaluated for inhibitory properties against wild-type HIV-1 reverse transcriptase (RT) and an RT carrying…”
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(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor by WISHKA, D. G, GRABER, D. R, KEISER, B. J, YAGI, Y, JEGANATHAN, A, SCHLACHTER, S. T, MURPHY, M. J, CLEEK, G. J, NUGENT, R. A, POPPE, S. M, SWANEY, S. M, HAN, F, KOPTA, L. A, WATT, W, WHITE, W. L, POEL, T.-J, THOMAS, R. C, VOORMAN, R. L, STEFANSKI, K. J, STEHLE, R. G, TARPLEY, W. G, MORRIS, J, OLMSTED, R. A, FRIIS, J. M, HOSLEY, J. D, ADAMS, W. J, SEEST, E. P, CASTLE, T. M, DOLAK, L. A

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Targeting Delavirdine/Atevirdine Resistant HIV-1:  Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors by Romero, Donna L, Olmsted, Robert A, Poel, Toni Jo, Morge, Raymond A, Biles, Carolyn, Keiser, Barbara J, Kopta, Laurice A, Friis, Jan M, Hosley, John D, Stefanski, Kevin J, Wishka, Donn G, Evans, David B, Morris, Joel, Stehle, Randy G, Sharma, Satish K, Yagi, Yoshihiko, Voorman, Richard L, Adams, Wade J, Tarpley, W. Gary, Thomas, Richard C

“…A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor)…”
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Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors:  Structure−Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs by Genin, Michael J., Poel, Toni J., Yagi, Yoshihiko, Biles, Carolyn, Althaus, Irene, Keiser, Barbara J., Kopta, Laurice A., Friis, Jan M., Reusser, Fritz, Adams, Wade J., Voorman, Richard L., Thomas, Richard C., Romero, Donna L.

“…The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via…”
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Synthesis and Structure−Activity Relationships of the (Alkylamino)piperidine-Containing BHAP Class of Non-Nucleoside Reverse Transcriptase Inhibitors:  Effect of 3-Alkylpyridine Ring Substitution by Genin, Michael J, Poel, Toni J, May, Paul D, Kopta, Laurice A, Yagi, Yoshihiko, Olmsted, Robert A, Friis, Janice M, Voorman, Richard L, Adams, Wade J, Thomas, Richard C, Romero, Donna L

“…Development of resistance to currently approved HIV therapies has continued to fuel research efforts to improve the metabolic stability and spectrum of…”
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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes by Olmsted, R A, Slade, D E, Kopta, L A, Poppe, S M, Poel, T J, Newport, S W, Rank, K B, Biles, C, Morge, R A, Dueweke, T J, Yagi, Y, Romero, D L, Thomas, R C, Sharma, S K, Tarpley, W G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Home cleaning-disinfection procedure for tracheal suction catheters by Shabino, C L, Erlandson, A L, Kopta, L A

“…The cost effectiveness of home care for pediatric tracheostomy patients has become a concern. One major cost component of this care is the tracheal suction…”
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A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation by Fan, Naisheng, Rank, Kenneth B, Slade, David E, Poppe, Susan M, Evans, David B, Kopta, Laurice A, Olmsted, Robert A, Thomas, Richard C, Tarpley, W. Gary, Sharma, Satish K

“…Selection of the IIIB strain of human immunodeficiency virus type (HIV-1) resistant to the (alkylamino)piperidine-bis(heteroaryl)piperazine (AAP-BHAP) U-104489…”
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(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor by Wishka, Donn G, Graber, David R, Kopta, Laurice A, Olmsted, Robert A, Friis, Janice M, Hosley, John D, Adams, Wade J, Seest, Eric P, Castle, Thomas M, Dolak, Lester A, Keiser, Barbara J, Yagi, Yoshihiko, Jeganathan, Azhwarsamy, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Nugent, Richard A, Poppe, Susan M, Swaney, Steven M, Han, Fusen, Watt, William, White, Wendy L, Poel, Toni-Jo, Thomas, Richard C, Voorman, Richard L, Stefanski, Kevin J, Stehle, Randall G, Tarpley, W. Gary, Morris, Joel

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(Alkylamino)piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1 sub(IIIB) with reduced replication phenotypes by Olmsted, R A, Slade, DE, Kopta, LA, Poppe, S M, Poel, T J, Newport, S W, Rank, K B, Biles, C, Morge, R A

“…The (alkylamino)piperidine bis(heteroaryl)piperizines (AAP-BHAPs) are a new class of human immunodeficiency virus type 1 (HIV-1)-specific inhibitors which were…”
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(-)-6-Chloro-2-[(1-furo[2,3-c] pyridin-5-yl-ethyl)thio]-4-p yrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor by Wishka, D G, Graber, DR, Kopta, LA, Olmsted, R A, Friis, J M, Hosley, J D, Adams, W J, Seest, E P, Castle, T M, Dolak, LA, Keiser, B J, Yagi, Yoshihiko, Jeganathan, A, Schlachter, ST

“…Considerable effort has been focused over the past decade on the development of the HIV-1 specific non-nucleoside reverse transcriptase inhibitors (NNRTIs),…”
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