Search Results - "KOPIL, Catherine"

Current and projected future economic burden of Parkinson’s disease in the U.S by Yang, Wenya, Hamilton, Jamie L., Kopil, Catherine, Beck, James C., Tanner, Caroline M., Albin, Roger L., Ray Dorsey, E., Dahodwala, Nabila, Cintina, Inna, Hogan, Paul, Thompson, Ted

“…Parkinson’s disease (PD) is one of the world’s fastest growing neurological disorders. Much is unknown about PD-associated economic burdens in the United…”
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A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research by Simuni, Tanya, Chahine, Lana M, Poston, Kathleen, Brumm, Michael, Buracchio, Teresa, Campbell, Michelle, Chowdhury, Sohini, Coffey, Christopher, Concha-Marambio, Luis, Dam, Tien, DiBiaso, Peter, Foroud, Tatiana, Frasier, Mark, Gochanour, Caroline, Jennings, Danna, Kieburtz, Karl, Kopil, Catherine M, Merchant, Kalpana, Mollenhauer, Brit, Montine, Thomas, Nudelman, Kelly, Pagano, Gennaro, Seibyl, John, Sherer, Todd, Singleton, Andrew, Stephenson, Diane, Stern, Matthew, Soto, Claudio, Tanner, Caroline M, Tolosa, Eduardo, Weintraub, Daniel, Xiao, Yuge, Siderowf, Andrew, Dunn, Billy, Marek, Kenneth

“…Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical features, with α-synuclein pathology as the gold standard to…”
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In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease by Chahine, Lana M., Beach, Thomas G., Brumm, Michael C., Adler, Charles H., Coffey, Christopher S., Mosovsky, Sherri, Caspell-Garcia, Chelsea, Serrano, Geidy E., Munoz, David G., White, Charles L., Crary, John F., Jennings, Danna, Taylor, Peggy, Foroud, Tatiana, Arnedo, Vanessa, Kopil, Catherine M., Riley, Lindsey, Dave, Kuldip D., Mollenhauer, Brit

“…OBJECTIVEThe Systemic Synuclein Sampling Study (S4) measured α-synuclein in multiple tissues and biofluids within the same patients with Parkinson disease (PD)…”
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Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest by Che, Dongfang, Li, Luchuan, Kopil, Catherine M, Liu, Ziyue, Guo, Wensheng, Neumar, Robert W

“…OBJECTIVE:Post-cardiac-arrest therapeutic hypothermia improves outcomes in comatose cardiac arrest survivors. This study tests the hypothesis that the efficacy…”
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Triggers and alleviating factors for fatigue in Parkinson's disease by Lin, Iris, Edison, Briana, Mantri, Sneha, Albert, Steven, Daeschler, Margaret, Kopil, Catherine, Marras, Connie, Chahine, Lana M

“…Fatigue is common in Parkinson's Disease, but few effective treatments are available for it. Exploring triggers and alleviating factors, including effects of…”
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The experience of care partners of patients with Parkinson's disease psychosis by Mantri, Sneha, Klawson, Emily, Albert, Steven, Rapoport, Robyn, Precht, Chelle, Glancey, Sarah, Daeschler, Margaret, Mamikonyan, Eugenia, Kopil, Catherine M, Marras, Connie, Chahine, Lana M

“…Parkinson's disease psychosis (PDP) has a major impact on quality of life and care partner burden; however, little is known about the lived experiences of care…”
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The Experience of OFF Periods in Parkinson’s Disease: Descriptions, Triggers, and Alleviating Factors by Mantri, Sneha, Lepore, Madeline, Edison, Briana, Daeschler, Margaret, Kopil, Catherine, Marras, Connie, Chahine, Lana

“…PURPOSEWearing off of Parkinson's disease medication is common, but triggers and coping strategies for this transient phenomenon are poorly understood. We…”
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Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's disease by Eidson, Lori N, Kannarkat, George T, Barnum, Christopher J, Chang, Jianjun, Chung, Jaegwon, Caspell-Garcia, Chelsea, Taylor, Peggy, Mollenhauer, Brit, Schlossmacher, Michael G, Ereshefsky, Larry, Yen, Mark, Kopil, Catherine, Frasier, Mark, Marek, Kenneth, Hertzberg, Vicki S, Tansey, Malú G

“…Efforts to identify fluid biomarkers of Parkinson's disease (PD) have intensified in the last decade. As the role of inflammation in PD pathophysiology becomes…”
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The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease by Visanji, Naomi P, Mollenhauer, Brit, Beach, Thomas G, Adler, Charles H, Coffey, Christopher S, Kopil, Catherine M, Dave, Kuldip D, Foroud, Tatiana, Chahine, Lana, Jennings, Danna

“…The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and…”
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A Coalition to Advance Treatments for Parkinson’s Disease, Dementia with Lewy Bodies, and Related Disorders by Kopil, Catherine M., Asis, Angelica, Campbell, Clyde, Chowdhury, Sohini, Dexter, David T., Fargo, Keith N., Lee, Karen K., Matthews, Helen, Taylor, Angela, Xiao, Yuge, Stephenson, Diane

“…Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) share underlying neuropathology. Despite overlapping biology, therapeutic development has been…”
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Patient-centered development of clinical outcome assessments in early Parkinson disease: key priorities and advances by Mestre, Tiago A., Stebbins, Glenn T., Stephenson, Diane, Dexter, David, Lee, Karen K., Xiao, Yuge, Dam, Tien, Kopil, Catherine M., Simuni, Tanya

“…Novel therapies with the ability to delay disease progression are a gap in the care of people living with Parkinson disease (PD) today. Clinical outcomes…”
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Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Advanced Cancer by SOLIT, David B, IVY, S. Percy, LARSON, Steven, SCHWARTZ, Lawrence, EGORIN, Merrill J, ROSEN, Neal, SCHER, Howard I, KOPIL, Catherine, SIKORSKI, Rachel, MORRIS, Michael J, SLOVIN, Susan F, KELLY, W. Kevin, DELACRUZ, Anthony, CURLEY, Tracy, HELLER, Glenn

“…Purpose: To define the maximum tolerated dose (MTD), toxicities, and pharmacokinetics of 17-allylamino-17-demethoxygeldanamycin (17-AAG) when administered…”
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Experience Induces Structural and Biochemical Changes in the Adult Primate Brain by Yevgenia Kozorovitskiy, Gross, Charles G., Catherine Kopil, Lisa Battaglia, Meghan Mc Breen, Alexis M. Stranahan, Gould, Elizabeth

“…Primates exhibit complex social and cognitive behavior in the wild. In the laboratory, however, the expression of their behavior is usually limited. A large…”
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Knowledge, Responsibilities, and Peer Advice From Care Partners of Patients With Parkinson Disease Psychosis by Mantri, Sneha, Edison, Briana, Alzyoud, Lamees, Albert, Steven M, Daeschler, Margaret, Kopil, Catherine, Marras, Connie, Chahine, Lana M

“…Care partners (CPs) of individuals with Parkinson disease psychosis (PDP) experience increased strain and rely on informal support networks. The objective of…”
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Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons by Kopil, Catherine M, Siebert, Adam P, Foskett, J Kevin, Neumar, Robert W

“…Disruption of neuronal Ca(2+) homeostasis plays a well-established role in cell death in a number of neurodegenerative disorders. Recent evidence suggests that…”
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Design of a virtual longitudinal observational study in Parkinson’s disease (AT‐HOME PD) by Schneider, Ruth B., Omberg, Larsson, Macklin, Eric A., Daeschler, Margaret, Bataille, Lauren, Anthwal, Shalini, Myers, Taylor L., Baloga, Elizabeth, Duquette, Sidney, Snyder, Phil, Amodeo, Katherine, Tarolli, Christopher G, Adams, Jamie L., Callahan, Katherine F, Gottesman, Joshua, Kopil, Catherine M., Lungu, Codrin, Ascherio, Alberto, Beck, James C., Biglan, Kevin, Espay, Alberto J., Tanner, Caroline, Oakes, David, Shoulson, Ira, Novak, Dan, Kayson, Elise, Ray Dorsey, Earl, Mangravite, Lara, Schwarzschild, Michael A., Simuni, Tanya

“…Objective The expanding power and accessibility of personal technology provide an opportunity to reduce burdens and costs of traditional clinical site‐centric…”
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Video research visits for atypical parkinsonian syndromes among Fox Trial Finder participants by Tarolli, Christopher G., Zimmerman, Grace A., Goldenthal, Steven, Feldman, Blake, Berk, Sarah, Siddiqi, Bernadette, Kopil, Catherine M., Chowdhury, Sohini, Biglan, Kevin M., Dorsey, E. Ray, Adams, Jamie L.

“…Use of video research visits in neurologic conditions is rising, but their utility has not been assessed in atypical parkinsonian syndromes. We sought to…”
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Increasing Efficiency of Recruitment in Early Parkinson's Disease Trials: A Case Study Examination of the STEADY-PD III Trial by Berk, Sarah, Greco, Brittany L, Biglan, Kevin, Kopil, Catherine M, Holloway, Robert G, Meunier, Claire, Simuni, Tanya

“…Challenges in clinical trial recruitment threaten the successful development of improved therapies. This is particularly true in Parkinson's disease (PD)…”
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Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca2+ buffering and causes neurodegeneration in primary cortical neurons by Kopil, Catherine M., Siebert, Adam P., Kevin Foskett, J., Neumar, Robert W.

“…Disruption of neuronal Ca2+ homeostasis plays a well‐established role in cell death in a number of neurodegenerative disorders. Recent evidence suggests that…”
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RNAi targeting µ-calpain increases neuron survival and preserves hippocampal function after global brain ischemia by Bevers, Matthew B., Ingleton, Lori P., Che, Dongfang, Cole, Jeffrey T., Li, Luchuan, Da, Tong, Kopil, Catherine M., Cohen, Akiva S., Neumar, Robert W.

“…The calpain family of cysteine proteases has a well-established causal role in neuronal cell death following acute brain injury. However, the relative…”
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