Search Results - "KOPCZYNSKI, C. C"

Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits by Kiel, Jeffrey W, Kopczynski, Casey C

“…AR-13324 is a potential new drug for the treatment of patients with glaucoma that has been shown to lower intraocular pressure (IOP) by increasing trabecular…”
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Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension by Lewis, Richard A, Levy, Brian, Ramirez, Nancy, Kopczynski, Casey C, Usner, Dale W, Novack, Gary D

“…To evaluate the ocular hypotensive efficacy of fixed-dose combinations of the Rho kinase inhibitor and norepinephrine transport inhibitor AR-13324 (0.01% and…”
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Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes by Li, Guorong, Mukherjee, Dibyendu, Navarro, Iris, Ashpole, Nicole E., Sherwood, Joseph M., Chang, Jinlong, Overby, Darryl R., Yuan, Fan, Gonzalez, Pedro, Kopczynski, Casey C., Farsiu, Sina, Stamer, W. Daniel

“…Visual impairment due to glaucoma currently impacts 70 million people worldwide. While disease progression can be slowed or stopped with effective lowering of…”
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Double-masked, Randomized, Dose–Response Study of AR-13324 versus Latanoprost in Patients with Elevated Intraocular Pressure by Bacharach, Jason, MD, Dubiner, Harvey B., MD, Levy, Brian, OD, MS, Kopczynski, Casey C., PhD, Novack, Gary D., PhD

“…Objective AR-13324 is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter. The objective of this 28-day study was to evaluate the ocular…”
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A Randomized, Phase 2 Study of 24-h Efficacy and Tolerability of Netarsudil in Ocular Hypertension and Open-Angle Glaucoma by Peace, James H., McKee, Hayley J., Kopczynski, Casey C.

“…Introduction Pharmacotherapy to lower intraocular pressure (IOP) is a mainstay of treatment aimed at delaying progression of visual field loss in ocular…”
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Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2) by Serle, Janet B., Katz, L. Jay, McLaurin, Eugene, Heah, Theresa, Ramirez-Davis, Nancy, Usner, Dale W., Novack, Gary D., Kopczynski, Casey C.

“…To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmic solution, a rho-kinase inhibitor and norepinephrine transporter…”
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Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2 by Asrani, Sanjay, Bacharach, Jason, Holland, Edward, McKee, Hayley, Sheng, Huan, Lewis, Richard A., Kopczynski, Casey C., Heah, Theresa

“…Introduction New open-angle glaucoma (OAG) and ocular hypertension (OHT) therapies that reduce treatment burden and improve outcomes relative to currently…”
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Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution: Rho Kinase Elevated IOP Treatment Trial (ROCKET-2) by Kahook, Malik Y., Serle, Janet B., Mah, Francis S., Kim, Terry, Raizman, Michael B., Heah, Theresa, Ramirez-Davis, Nancy, Kopczynski, Casey C., Usner, Dale W., Novack, Gary D.

“…To evaluate netarsudil 0.02% ophthalmic solution in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). Double-masked, randomized,…”
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Consensus recommendations for trabecular meshwork cell isolation, characterization and culture by Keller, Kate E., Bhattacharya, Sanjoy K., Borrás, Theresa, Brunner, Thomas M., Chansangpetch, Sunee, Clark, Abbott F., Dismuke, W. Michael, Du, Yiqin, Elliott, Michael H., Ethier, C. Ross, Faralli, Jennifer A., Freddo, Thomas F., Fuchshofer, Rudolf, Giovingo, Michael, Gong, Haiyan, Gonzalez, Pedro, Huang, Alex, Johnstone, Murray A., Kaufman, Paul L., Kelley, Mary J., Knepper, Paul A., Kopczynski, Casey C., Kuchtey, John G., Kuchtey, Rachel W., Kuehn, Markus H., Lieberman, Raquel L., Lin, Shan C., Liton, Paloma, Liu, Yutao, Lütjen-Drecoll, Elke, Mao, Weiming, Masis-Solano, Marisse, McDonnell, Fiona, McDowell, Colleen M., Overby, Darryl R., Pattabiraman, Padmanabhan P., Raghunathan, Vijay K., Rao, P. Vasanth, Rhee, Douglas J., Chowdhury, Uttio Roy, Russell, Paul, Samples, John R., Schwartz, Donald, Stubbs, Evan B., Tamm, Ernst R., Tan, James C., Toris, Carol B., Torrejon, Karen Y., Vranka, Janice A., Wirtz, Mary K., Yorio, Thomas, Zhang, Jie, Zode, Gulab S., Fautsch, Michael P., Peters, Donna M., Acott, Ted S., Stamer, W. Daniel

“…Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow…”
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Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma by Lin, Cheng-Wen, Sherman, Bryan, Moore, Lori A, Laethem, Carmen L, Lu, Da-Wen, Pattabiraman, Padmanabhan P, Rao, Ponugoti Vasantha, deLong, Mitchell A, Kopczynski, Casey C

“…Rho-associated protein kinase (ROCK) inhibitors lower intraocular pressure (IOP) by increasing aqueous outflow through the trabecular meshwork (TM). The…”
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Netarsudil ophthalmic solution 0.02% for the treatment of patients with open-angle glaucoma or ocular hypertension by Kopczynski, C C, Heah, T

“…Once-daily (p.m.) netarsudil ophthalmic solution 0.02% (Rhopressa) is approved in the United States for lowering elevated intraocular pressure (IOP) in…”
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high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis by Kopczynski, C.C, Noordermeer, J.N, Serano, T.L, Chen, W.Y, Pendleton, J.D, Lewis, S, Goodman, C.S, Rubin, G.M

“…Secreted and transmembrane proteins play an essential role in intercellular communication during the development of multicellular organisms. Because only a…”
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Phase 3 Clinical Trial Comparing the Safety and Efficacy of Netarsudil to Ripasudil in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: Japan Rho Kinase Elevated Intraocular Pressure Treatment Trial (J-ROCKET) by Araie, Makoto, Sugiyama, Kazuhisa, Aso, Kenji, Kanemoto, Koji, Iwata, Ryo, Hollander, David A., Senchyna, Michelle, Kopczynski, Casey C.

“…Introduction A clinical trial evaluated ocular hypotensive efficacy and safety of netarsudil 0.02% once daily (QD) relative to ripasudil 0.4% twice daily…”
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A Neural Tetraspanin, Encoded by late bloomer, That Facilitates Synapse Formation by Kopczynski, Casey C., Davis, Graeme W., Goodman, Corey S.

“…Upon contacting its postsynaptic target, a neuronal growth cone transforms into a presynaptic terminal. A membrane component on the growth cone that…”
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Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma by Sturdivant, Jill M., Royalty, Susan M., Lin, Cheng-Wen, Moore, Lori A., Yingling, Jeffrey D., Laethem, Carmen L., Sherman, Bryan, Heintzelman, Geoffrey R., Kopczynski, Casey C., deLong, Mitchell A.

“…[Display omitted] Inhibition of Rho kinase (ROCK) to improve fluid outflow through the trabecular meshwork and lower intraocular pressure is a strategy for the…”
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Emerging trabecular outflow drugs by Kopczynski, Casey C, Epstein, David L

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Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila by Noordermeer, J N, Kopczynski, C C, Fetter, R D, Bland, K S, Chen, W Y, Goodman, C S

“…The midline glia are specialized, nonneuronal cells at the midline of the Drosophila central nervous system (CNS). During development, the midline glia provide…”
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Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study by Khouri, Albert S., Serle, Janet B., Bacharach, Jason, Usner, Dale W., Lewis, Richard A., Braswell, Puiwah, Kopczynski, Casey C., Heah, Theresa, Bacharach, Jason, Benza, Robert, Boyle, John W., Butler, Michelle, Cacioppo, Leonard Robert, Cardona, Jose F., Colborn, Valerie A., Day, Douglas G., Douglass, David T., El-Harazi, Sherif M., Ghate, Deepta, Hartman, Carl, Haverly, Robert F., Katzman, Barry, Kim, Max, Koo, Edward Y., Korenfeld, Michael S., Kwapiszeski, Bradley, Lane, Lydia, Lin, Christopher, Logan, Andrew Gardner, Lozier, Jeffrey Raymond, McQuirter, Henry, Mundorf, Thomas K., Olander, Kenneth, Ou, Richard J., Panzo, Gregory J., Peace, James H., Protzko, Eugene E., Ritch, Robert, Sall, Kenneth, Schechter, Barry A., Seltzer, Samuel Eric, Shah, Pankajkumar G., Sharpe, Elizabeth, Lee Shettle, Philip, Shulman, David G., Singh, Inder Paul, Smith, Stacy R., Smith, Stephen E., Smyth-Medina, Robert John, Sorenson, Robert C., Sturm, Richard, Sulkowski, Gregory M., Sutton, James D., Tepedino, Michael, Tsai, Julie, Tubbs, Carl B., Tukel, David B., Walters, Thomas Richard, Wirta, David L.

“…To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) and timolol twice daily (BID). Double-masked, randomized,…”
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PHASE 2 RANDOMIZED STUDY (ORION-1) OF A NOVEL, BIODEGRADABLE DEXAMETHASONE IMPLANT (AR-1105) FOR THE TREATMENT OF MACULAR EDEMA DUE TO CENTRAL OR BRANCH RETINAL VEIN OCCLUSION by Singer, Michael A., Boyer, David S., Williams, Stuart, McKee, Hayley, Kerr, Kevin, Pegoraro, Tyler, Trevino, Leo, Kopczynski, Casey C., Hollander, David A.

“…AR-1105 is a novel biodegradable sustained-release dexamethasone implant designed to deliver 6-month durability. This Phase 2 study evaluated two AR-1105…”
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Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates by KOPCZYNSKI, C. C, ALTON, A. K, FECHTEL, K, KOOH, P. J, MUSKAVITCH, M. A. T

“…Delta (D1) is required for normal segregation of the embryonic ectoderm into neural and epidermal cell lineages in Drosophila melanogaster. Loss-of-function…”
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