Search Results - "KOOPMAN, PETER"

Sry: the master switch in mammalian sex determination by Kashimada, Kenichi, Koopman, Peter

“…SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to…”
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Building the mammalian testis: origins, differentiation, and assembly of the component cell populations by Svingen, Terje, Koopman, Peter

“…Development of testes in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male…”
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The Curious World of Gonadal Development in Mammals by Koopman, Peter

“…The distinct sex phenotypes of male and female hinge on the development of the fetal gonads as testes or ovaries, in turn, regulated by the molecular genetic…”
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Retinoic acid, meiosis and germ cell fate in mammals by Bowles, Josephine, Koopman, Peter

“…Although mammalian sex is determined genetically, the sex-specific development of germ cells as sperm or oocytes is initiated by cues provided by the gonadal…”
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Sex Determination in the Mammalian Germline by Spiller, Cassy, Koopman, Peter, Bowles, Josephine

“…Sexual reproduction crucially depends on the production of sperm in males and oocytes in females. Both types of gamete arise from the same precursor, the germ…”
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Sex Determination and Gonadal Development in Mammals by Wilhelm, Dagmar, Palmer, Stephen, Koopman, Peter

“…Division of Molecular Genetics and Development and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular…”
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Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1 by Zhao, Liang, Svingen, Terje, Ng, Ee Ting, Koopman, Peter

“…Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan…”
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The makings of maleness: towards an integrated view of male sexual development by Koopman, Peter, Wilhelm, Dagmar

“…As the mammalian embryo develops, it must engage one of the two distinct programmes of gene activity, morphogenesis and organogenesis that characterize males…”
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Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9 by Croft, Brittany, Ohnesorg, Thomas, Hewitt, Jacqueline, Bowles, Josephine, Quinn, Alexander, Tan, Jacqueline, Corbin, Vincent, Pelosi, Emanuele, van den Bergen, Jocelyn, Sreenivasan, Rajini, Knarston, Ingrid, Robevska, Gorjana, Vu, Dung Chi, Hutson, John, Harley, Vincent, Ayers, Katie, Koopman, Peter, Sinclair, Andrew

“…Disorders of sex development (DSDs) are conditions affecting development of the gonads or genitalia. Variants in two key genes, SRY and its target SOX9 , are…”
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Sex determination in mammalian germ cells: extrinsic versus intrinsic factors by Bowles, Josephine, Koopman, Peter

“…Mammalian germ cells do not determine their sexual fate based on their XX or XY chromosomal constitution. Instead, sexual fate is dependent on the gonadal…”
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Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a by Kuroki, Shunsuke, Matoba, Shogo, Akiyoshi, Mika, Matsumura, Yasuko, Miyachi, Hitoshi, Mise, Nathan, Abe, Kuniya, Ogura, Atsuo, Wilhelm, Dagmar, Koopman, Peter, Nozaki, Masami, Kanai, Yoshiakira, Shinkai, Yoichi, Tachibana, Makoto

“…Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone…”
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Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone by Gonen, Nitzan, Quinn, Alexander, O'Neill, Helen C, Koopman, Peter, Lovell-Badge, Robin

“…During mouse sex determination, transient expression of the Y-linked gene Sry up-regulates its direct target gene Sox9, via a 3.2 kb testis specific enhancer…”
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ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries by Bowles, Josephine, Feng, Chun-Wei, Miles, Kim, Ineson, Jessica, Spiller, Cassy, Koopman, Peter

“…Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and…”
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Of sex and determination: marking 25 years of Randy, the sex-reversed mouse by Koopman, Peter, Sinclair, Andrew, Lovell-Badge, Robin

“…On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV…”
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Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse by Feng, Chun-Wei, Burnet, Guillaume, Spiller, Cassy M, Cheung, Fiona Ka Man, Chawengsaksophak, Kallayanee, Koopman, Peter, Bowles, Josephine

“…In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( ). is expressed specifically in…”
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Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development by Polanco, Juan Carlos, Wilhelm, Dagmar, Davidson, Tara-Lynne, Knight, Deon, Koopman, Peter

“…Male development in mammals is normally initiated by the Y-linked gene Sry, which activates expression of Sox9, leading to a cascade of gene activity required…”
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Sry and the hesitant beginnings of male development by Polanco, Juan Carlos, Koopman, Peter

“…In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. The discovery of Sry in 1990 was expected to provide the key…”
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Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination by Zhao, Liang, Wang, Chenwei, Lehman, Melanie L., He, Mingyu, An, Jiyuan, Svingen, Terje, Spiller, Cassy M., Ng, Ee Ting, Nelson, Colleen C., Koopman, Peter

“…Mammalian sex determination hinges on sexually dimorphic transcriptional programs in developing fetal gonads. A comprehensive view of these programs is crucial…”
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Retinoid Signaling Determines Germ Cell Fate in Mice by Bowles, Josephine, Knight, Deon, Smith, Christopher, Wilhelm, Dagmar, Richman, Joy, Mamiya, Satoru, Yashiro, Kenta, Chawengsaksophak, Kallayanee, Wilson, Megan J, Rossant, Janet, Hamada, Hiroshi, Koopman, Peter

“…Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid,…”
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Gene editing of the multi-copy H2A.B gene and its importance for fertility by Anuar, Nur Diana, Kurscheid, Sebastian, Field, Matt, Zhang, Lei, Rebar, Edward, Gregory, Philip, Buchou, Thierry, Bowles, Josephine, Koopman, Peter, Tremethick, David J, Soboleva, Tatiana A

“…Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene…”
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