Search Results - "KONUR, Abdo"

Distinct Roles for IL-1 Receptor Type I Signaling in Early Versus Established Leishmania major Infections by Kostka, Susanna Lopez, Knop, Jürgen, Konur, Abdo, Udey, Mark C., von Stebut, Esther

“…IL-1α/β released by infected dendritic cells (DC) plays a critical role in the development of protective immunity against Leishmania major. Previous studies…”
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Cytokine repertoire during maturation of monocytes to macrophages within spheroids of malignant and non‐malignant urothelial cell lines by Konur, Abdo, Kreutz, Marina, Knüchel, Ruth, Krause, Stefan W., Andreesen, Reinhard

“…Terminal maturation of human blood monocytes to macrophages (MAC) in vivo is believed to be important for the morphology, antigen expression and functional…”
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Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-α responses by pDC by Waibler, Zoe, Anzaghe, Martina, Konur, Abdo, Akira, Shizuo, Müller, Werner, Kalinke, Ulrich

“…Upon stimulation with a wide range of concentrations of CpG oligodeoxynucleotide 2216 (CpG 2216), plasmacytoid DC are induced to produce type I IFN (IFN-α/β)…”
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Rapid identification and sorting of viable virus-reactive CD4 + and CD8 + T cells based on antigen-triggered CD137 expression by Wehler, Thomas C., Karg, Michael, Distler, Eva, Konur, Abdo, Nonn, Marion, Meyer, Ralf G., Huber, Christoph, Hartwig, Udo F., Herr, Wolfgang

“…Current methods for the detection and isolation of antigen-specific CD4 + and CD8 + T cells require the availability of peptide/MHC multimers or are restricted…”
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Functional TCR retrieval from single antigen-specific human T cells reveals multiple novel epitopes by Simon, Petra, Omokoko, Tana A, Breitkreuz, Andrea, Hebich, Lisa, Kreiter, Sebastian, Attig, Sebastian, Konur, Abdo, Britten, Cedrik M, Paret, Claudia, Dhaene, Karl, Türeci, Özlem, Sahin, Ugur

“…The determination of the epitope specificity of disease-associated T-cell responses is relevant for the development of biomarkers and targeted immunotherapies…”
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Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell–depleted reduced-intensity transplantation by Meyer, Ralf G., Britten, Cedrik M., Wehler, Daniela, Bender, Klaus, Hess, Georg, Konur, Abdo, Hartwig, Udo F., Wehler, Thomas C., Ullmann, Andrew J., Gentilini, Chiara, Uharek, Lutz, Huber, Christoph, Kolbe, Karin, Herr, Wolfgang

“…Allogeneic hematopoietic stem cell transplantation (SCT) regimens incorporating the lymphocytotoxic CD52 antibody alemtuzumab demonstrate efficient engraftment…”
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Interferon (IFN)-γ is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-γ and tumour necrosis factor-α production by Konur, A., Schulz, U., Eissner, G., Andreesen, R., Holler, E.

“…Summary Background  Apoptosis of keratinocytes or intestinal epithelial cells is an important pathophysiological mechanism of organ damage during acute…”
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Cytotoxic T lymphocytes responding to low dose TRP2 antigen are induced against B16 melanoma by liposome- encapsulated TRP2 peptide and CpG DNA adjuvant by JEROME, Valérie, GRASER, Andreas, MÜLLER, Rolf, KONTERMANN, Roland E, KONUR, Abdo

“…The induction of a potent and specific T cell response is a major challenge in the development of efficacious cancer vaccine strategies. We applied a novel…”
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The CD38-Positive and CD38-Negative Subsets of CD34(high)-Positive Primary Acute Myeloid Leukemia Blasts Differ Considerably in the Expression of Immune Recognition Molecules by Distler, Eva, Jürchott, Anna, Konur, Abdo, Schneider, Astrid, Wagner, Eva M., Huber, Christoph, Meyer, Ralf G., Herr, Wolfgang

“…Acute myeloid leukemia (AML) is thought to arise from a rare putative ‘leukemic stem cell’ that is capable of self-renewal and formation of leukemic blasts…”
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Reconstitution of CD52-Negative CD4 T Cells after Alemtuzumab-Based T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation by Wagner, Eva M, Lay, Aline N, Wenzel, Sina, Schmitt, Timo, Hemmerling, Julia, Konur, Abdo, Bender, Klaus, Huber, Christoph, Herr, Wolfgang, Meyer, Ralf G

“…The human CD52 molecule is the target of the monoclonal antibody Alemtuzumab, which is used for treating patients with chemo-refractory chronic lymphocytic…”
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Rapid Detection and Isolation of Viable Virus-Reactive CD4+ and CD8+ T Cells Based on Activation-Induced CD137 Expression by Wehler, Thomas C., Karg, Michael, Konur, Abdo, Nonn, Marion, Meyer, Ralf G., Huber, Christoph, Hartwig, Udo F., Herr, Wolfgang

“…Current methods for the detection and isolation of antigen-specific CD4+ and CD8+ T cells require the availability of peptide/MHC multimers or are restricted…”
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A PCR-Based Assay for the Detection of Langerhans-Cell Chimerism after Allogeneic Stem Cell Transplantation by Meyer, Ralf G., Bakhtiar, Shahrzad, Bender, Klaus, Schmitt, Timo, Konur, Abdo, Huber, Christoph, Herr, Wolfgang

“…Early acute GVHD of the skin frequently occurs in patients after allogeneic hematopoietic stem cell transplantation. Although T cell depletion reduces the…”
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Chimerism Analysis of Langerhans Cells Early after T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation by Schmitt, Timo, Schneiker, Kerstin, Konur, Abdo, Hadian, Ali, Bender, Klaus, von Stebut, Esther, Kolbe, Karin, Huber, Christoph, Herr, Wolfgang, Meyer, Ralf G.

“…Skin is the most frequently affected organ in acute graft versus host disease (GVHD). Data from murine studies support the hypothesis that the interaction of…”
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Preemptive Transfer of GMP-Grade CD8-Depleted Donor Lymphocytes after T-Cell Depleted Reduced-Intensity Transplantation by Meyer, Ralf G., Britten, Cedrik M., Konur, Abdo, Bender, Klaus, Wehler, Daniela, Hartwig, Udo, Wehler, Thomas C., Gentilini, Chiara, Uharek, Lutz, Huber, Christoph, Kolbe, Karin, Herr, Wolfgang

“…The combination of fludarabin (150mg/m2) / melphalan (140mg/m2) based reduced-intensity allo-transplantation (RIT) with in vivo T-cell depletion (TCD) by the…”
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Liposome-Encapsulated Adjuvants are Potent Inducers of Antigen-Specific T-Cells in Vivo by Konur, Abdo, Graser, Andreas, Klamp, Inga, Kreiter, Sebastian, Selmi, Abderraouf, Diken, Mustafa, Huber, Christoph, Tureci, Ozlem, Sahin, Ugur

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Three‐dimensional co‐culture of human monocytes and macrophages with tumor cells: Analysis of macrophage differentiation and activation by Konur, Abdo, Kreutz, Marina, Knüchel, Ruth, Krause, Stefan W., Andreesen, Reinhard

“…Here we report on an experimental system for generating TAM in vitro by culturing human MO and MO‐derived macrophages (MAC) within 3‐dimensional multicellular…”
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Human monocytes induce a carcinoma cell line to secrete high amounts of nitric oxide by Konur, A, Krause, SW, Rehli, M, Kreutz, M, Andreesen, R

“…Nitric oxide (NO) is a short-lived pleiotropic mediator with a multitude of biologic functions. The inducible form of NO synthase (iNOS) is responsible for the…”
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T helper target cell DNA fragmentation through a CD4-positive T suppressor cell clone inducing specific unresponsiveness by Becker, C, Konur, A, Rademaekers, A, Kodelja, V, Partenheimer, A, Pauels, H G, Kölsch, E

“…The CD4-positive bovine serum albumin (BSA)-specific Ts cell clone BVI/5 from a CBA/J mouse tolerized to low doses of BSA induces specific unresponsiveness in…”
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