Search Results - "KONTOS, H A"

Oxygen radicals in cerebral ischemia : The 2001 Willis Lecture by KONTOS, Hermes A

“…The sequential univalent reduction of oxygen generates superoxide, hydrogen peroxide, and hydroxyl radical. The generation of hydroxyl radical is dependent on…”
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Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite by Wei, E P, Kontos, H A, Beckman, J S

“…We investigated the role of potassium channels in the vasodilator action of hydrogen peroxide, peroxynitrite, and superoxide on cerebral arterioles. We studied…”
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Adverse effects of prolonged hyperventilation in patients with severe head injury : a randomized clinical trial by MUIZELAAR, J. P, MARMAROU, A, WARD, J. D, KONTOS, H. A, CHOI, S. C, BECKER, D. P, GRUEMER, H, YOUNG, H. F

“…There is still controversy over whether or not patients should be hyperventilated after traumatic brain injury, and a randomized trial has never been…”
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Oxygen radicals in cerebral ischemia by Nelson, C W, Wei, E P, Povlishock, J T, Kontos, H A, Moskowitz, M A

“…Superoxide production was measured as the superoxide dismutase (SOD)-inhibitable portion of nitro blue tetrazolium (NBT) reduction after cerebral…”
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Arginine analogues inhibit responses mediated by ATP-sensitive K+ channels by Kontos, H A, Wei, E P

“…Because arginine analogues have been reported to block the vasodilator response to hypercapnia, we investigated the effect of nitro-L-arginine (L-NNA) on the…”
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Calcitonin Gene-Related Peptide Mediates Nitroglycerin and Sodium Nitroprusside-Induced Vasodilation in Feline Cerebral Arterioles by Wei, Enoch P, Moskowitz, Michael A, Boccalini, Pia, Kontos, Hermes A

“…The cerebral vasodilator response induced by topical nitroglycerin and nitroprusside was examined in cats equipped with cranial windows for the observation of…”
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Fluid percussion injury transiently increases then decreases brain oxygen consumption in the rat by Levasseur, J E, Alessandri, B, Reinert, M, Bullock, R, Kontos, H A

“…The oxygen consumption (VO2 microL/h/mg) of sham and of traumatized rat brains within 30 min and 6 h after a lateral fluid percussion injury (FPI) was measured…”
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Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase : a phase II trial by MUIZELAAR, J. P, MARMAROU, A, YOUNG, H. F, CHOI, S. C, WOLF, A, SCHNEIDER, R. L, KONTOS, H. A

“…Formation of the oxygen radical superoxide anion is one of the final events of several metabolic pathways in the cascade that leads to delayed neuronal death…”
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Validity of cerebral arterial blood flow calculations from velocity measurements by Kontos, H A

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PGH Synthase and Lipoxygenase Generate Superoxide in the Presence of NADH or NADPH by Kukreja, Rakesh C, Kontos, Hermes A, Hess, Michael L, Ellis, Earl F

“…Purified PGH synthase when acting on arachidonic acid in the presence of reduced nicotinamide-adenine dinucleotide or reduced nicotinamide-adenine dinucleotide…”
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Superoxide production in experimental brain injury by Kontos, H A, Wei, E P

“…The appearance of superoxide anion radicals in cerebral extracellular space during and after experimental fluid-percussion brain injury was investigated in…”
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Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583 by Kontos, H A, Wei, E P

“…Methylene blue and 6-anilino,5,8-quinolinedione (LY83583) are used extensively to block activation of guanylate cyclase. Both agents generate oxygen radicals…”
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Oxygen Radicals in Cerebral Vascular Injury by Kontos, Hermes A

“…Acute, severe increases in arterial blood pressure cause sustained cerebral arteriolar dilation, abnormal reactivity to carbon dioxide and to changes in blood…”
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Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide by Marshall, J J, Wei, E P, Kontos, H A

“…We investigated the mechanisms of cerebral arteriolar dilation from topical acetylcholine and the nitrovasodilators, sodium nitroprusside, nitroglycerin, and…”
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Oxygen radicals in CNS damage by Kontos, H A

“…The products of univalent reduction of oxygen, superoxide anion radical, hydrogen peroxide, and the hydroxyl radical, are capable of causing cellular damage…”
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Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo by Kontos, C D, Wei, E P, Williams, J I, Kontos, H A, Povlishock, J T

“…We used a cytochemical technique for the detection of superoxide in cerebral inflammation and ischemia-reperfusion in anesthetized cats. The technique is based…”
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Endothelium-Derived Relaxing Factors: A Perspective From In Vivo Data by Marshall, J Jeffrey, Kontos, Hermes A

“…We review below published studies of endothelium-dependent vasodilation in vivo. Endothelium-dependent vasodilation has been demonstrated in conduit arteries…”
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The role of neuroeffector mechanisms in cerebral hyperperfusion syndromes by MACFARLANE, R, MOSKOWITZ, M. A, SAKAS, D. E, TASEDMIROGLU, E, WEI, E. P, KONTOS, H. A

“…Cerebral hyperperfusion, a state in which blood flow exceeds the metabolic needs of brain, may complicate a number of neurological and neurosurgical…”
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Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation by Khandelwal, S R, Randad, R S, Lin, P S, Meng, H, Pittman, R N, Kontos, H A, Choi, S C, Abraham, D J, Schmidt-Ullrich, R

“…The in vivo effects on hemoglobin (Hb)-O2 affinity and tissue PO2 were investigated after intraperitoneal administration of…”
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Appearance of Superoxide Anion Radical in Cerebral Extracellular Space during Increased Prostaglandin Synthesis in Cats by Kontos, Hermes A, Wei, Enoch P, Ellis, Earl F, Jenkins, Larry W, Povlishock, John T, Rowe, G Thomas, Hess, Michael L

“…When increased prostaglandin synthesis was induced in anesthetized cats equipped with cranial windows by topical application of arachidonate (200 μg/ml) or…”
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