Search Results - "KONOVALOVA, N. P"

Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance by Konovalova, N.P, Goncharova, S.A, Volkova, L.M, Rajewskaya, T.A, Eremenko, L.T, Korolev, A.M

“…The potentiality to increase the chemotherapeutic effectiveness of some cytostatics in low, subtherapeutic doses in combination with nitric oxide (NO) donor…”
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Synthesis, characterization, and antileukemic activity of new water-soluble analogs of prodimin by Goncharova, S. A., Yakushchenko, I. K., Raevskaya, T. A., Yakushchenko, T. N., Konovalova, N. P.

“…Two new compounds from the class of bis(3-halopropionyl)amides were synthesized by the reaction of 3-halopropionyl chloride with N,N ′-dimethylethylenediamine…”
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The Effectiveness of Cyclic Hydroxamic Acid CHA-5 against Drug-Resistant P388 Leukemia Strains by Goncharova, S. A., Vystorop, I. V., Raevskaya, T. A., Konovalova, N. P.

“…We studied the effectiveness of cyclic hydroxamic acid CHA-5 against drug-resistant and multidrug-resistant murine P388 leukemia strains. More than 60% mice…”
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Effect of Nitric Oxide Donor, a Modulator of Tumor Drug Resistance, on Cell Death and p53 Protein Expression by Rajewskaya, T. A, Goncharova, S. A, Konovalova, N. P, Terent'ev, A. A, Lapshina, M. A

“…Exogenous NO donor 3,3-bis-(nitroxymethyl)oxetane (NMO) was synthesized at the Institute for Problems of Chemical Physics (Russian Academy of Sciences). This…”
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Synthesis of oxalic acid derivatives and their antitumor activity in experiments in vivo by Fedorov, B. S., Goncharova, S. A., Rajevskaya, T. A., Eremeev, A. B., Utenyshev, A. N., Fadeev, M. A., Bogdanov, G. N., Konovalova, N. P., Aldoshin, S. M.

“…A series of amino acid derivatives of oxalic acid were obtained. In combination therapy with conventional cytostatics used in lower doses, the new compounds…”
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Effect of drug resistance modulator, NO donor, on membrane structure and function of membrane-bound Ca²⁺-activated Mg²⁺-dependent ATPase by Rajewskaya, T. A, Goncharova, S. A, Konovalova, N. P, Kotelnikova, R. A, Tatyanenko, L. V

“…Exogenous NO donor 3,3-bis-(nitroxymethyl)oxetane (NMO) was synthesized at the Institute for Problems of Chemical Physics (Russian Academy of Sciences). This…”
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Ways to enhance chemosensitizing of tumor cells with NO donors in tumor therapy with cytostatics and hydroxamic acids by Bogatyrenko, T N, Kuropteva, Z V, Bayder, L M, Serkov, I V, Bogatyrenko, V R, Sashenkova, T E, Klimanova, E N, Mishchenko, D V, Konovalova, N P

“…The influence of an organic NO donor belonging to non-steroidal anti-inflammatory drugs (NSAIDs) — NO-indomethacin (NO-Ind) on the antitumor effect of…”
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The effect of ascorbic acid on the efficiency of cytotoxic therapy with cytostatic drugs in combination with NaNO3 and hydroxamic acids by Bogatyrenko, T. N., Kuropteva, Z. V., Bayder, L. M., Sashenkova, T. E., Mishchenko, D. V., Bogatyrenko, V. R., Konovalova, N. P.

“…The present investigation is based on the paradoxical dichotomy of the biological action of nitric oxide (NO). Depending on its concentration in the organism,…”
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Hydroxamic acids: synthesis and adjuvant activity in combinatorial anticancer therapy by Fedorov, B. S., Fadeev, M. A., Eremeev, A. B., Konovalova, N. P., Bogdanov, G. N., Tatyanenko, L. V., Sashenkova, T. E., Mishchenko, D. V.

“…Monoand disubstituted N -hydroxyamides of dicarboxylic acids were prepared by reaction of dicarboxylic acids or acid anhydrides with hydroxylamine. The use of…”
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Nitrotriazole AK-2123 Enhances Mitomycin C Activity in Mice Bearing Multidrug-Resistant Tumors by Goncharova, S.A., Rajewskaya, T.A., Konovalova, N.P., Kagiya, T.V.

“…The often observed cross resistance of multidrug-resistant (MDR) tumors to mitomycin C (MMC) is surprising, as these tumors are, as a rule, sensitive to…”
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Ultralow doses of various drugs in chemotherapy of experimental tumors by Konovalova, N P

“…Antitumor activity of ultralow doses of cytostatic lonidamine and effects of various biological preparations in ultralow doses (chemosensitizer,…”
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Synthesis and antimetastatic activity of metal complexes based on substituted pyridinecarboxylic acid amides and platinum tetrachloride by Fedorov, B. S, Fadeev, M. A, Kozub, G. I, Aldoshin, S. M, Aliev, Z. G, Atovmyan, L. O, Konovalova, N. P, Sashenkova, T. E, Kondrat'eva, T. A, Blokhina, S. V

“…Previously unreported platinum tetrachloride derivatives have been synthesized via the interaction between dipotassium- and disodiumhexachloroplatinates with…”
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Synthesis and antitumor properties of new platinum(IV) complexes with aminonitroxyl radicals by Sen’, V. D., Golubev, V. A., Lugovskaya, N. Yu, Sashenkova, T. E., Konovalova, N. P.

“…Acylation of cis,trans,cis-Pt super(IV)(RNH sub(2))(NH sub(3))(OH) sub(2)Cl sub(2) with acetic anhydride afforded complexes cis,trans,cis-Pt super(IV)(RNH…”
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Nitroxyl radicals decrease toxicity of cytostatic agents by Konovalova, N P, Diatchkovskaya, R F, Volkova, L M, Varfolomeev, V N

“…Nitroxyl radicals of a series of piperidineoxyles and pirrolinoxyles increase the tolerance of experimental animals to the injection of otherwise lethal doses…”
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Modulatory effect of tempol on toxicity and antitumor activity of 6-mercaptopurine and on P450 cytochrome level by Konovalova, N P, Diatchkovskaya, R F, Volkova, L M, Varfolomeev, V N

“…Low selectivity of contemporary antitumor drugs requires a search for its improvement. In this context, nitroxyl radicals are of interest as promising…”
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Phosphorus-containing metabolites in anthracycline-resistant murine leukemia P388 cells by SHIRYAEVA, O. A, SEMENOVA, N. A, SIBELDINA, L. A, GONCHAROVA, S. A, KONOVALOVA, N. P

“…The method of 31P nuclear magnetic resonance was used to study in vivo the level of phosphorus-containing metabolites in P388 leukemia cells sensitive or…”
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Radiosensitizer AK-2123 as modulating agent in the chemotherapy of experimental metastases by Konovalova, N P, Diatchkovskaya, R F, Volkova, L M, Kagiya, T V

“…Therapeutic effect of Cyclophosphamide (CPA) and radiosensitizer AK-2123 (AK) combination versus CPA alone in the same doses was investigated on transplanted…”
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Subrenal capsule assay of human tumor chemosensitivity by KONOVALOVA, N. P, DIATCHKOVSKAYA, R. F, GANIEVA, L. K, VOLKOVA, L. M, LAPSHIN, I. M, RUDAKOV, B. Y, SHAPOSHNIKOV, Y. G, SHAPIRO, A. B

“…Breast and colon tumor response to emoxyl, a nitroxyl derivative of daunomycin, was detected using human tumor heterotransplantation under the renal capsule of…”
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Potential anticancer agents--nitroxyl derivatives of Rubomycin by Emanuel, N M, Konovalova, N P, Diatchkovskaya, R F

“…Two new of the spin-labeled analogues of Rubomycin were studied. It was shown that spin-labeled derivatives were less toxic than the parent compound and had a…”
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Pharmacokinetics of a spin-labeled rubomycin analog by Konovalova, N P, Diatchkovskaya, R F, Kukushkina, G V, Volkova, L M, Varfolomeev, V N, Dombrovsky, L S, Shapiro, A B

“…Pharmacokinetics of a spin-labeled analog of rubomycin (ruboxyl) was studied. Differences were found in ruboxyl pharmacokinetics in normal and tumor-bearing…”
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