Search Results - "KONKEL, Michael J"

Anxiolytic- and Antidepressant-like Profiles of the Galanin-3 Receptor ($Gal_3$) Antagonists SNAP 37889 and SNAP 398299 by Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Zheng, Kang, Xu, Zhi-Qing David, Hökfelt, Tomas, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Craig, Douglas A., Christophe P. G. Gerald, Branchek, Theresa A.

“…The neuropeptide galanin mediates its effects through the receptor subtypes$Gal_1$,$Gal_2$, and$Gal_3$and has been implicated in anxiety-and depression-related…”
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3-Arylimino-2-indolones Are Potent and Selective Galanin GAL3 Receptor Antagonists by Konkel, Michael J, Lagu, Bharat, Boteju, Lakmal W, Jimenez, Hermogenes, Noble, Stewart, Walker, Mary W, Chandrasena, Gamini, Blackburn, Thomas P, Nikam, Sham S, Wright, Jon L, Kornberg, Brian E, Gregory, Tracy, Pugsley, Thomas A, Akunne, Hyacinth, Zoski, Kim, Wise, Lawrence D

“…A series of 3-imino-2-indolones are the first published, high-affinity antagonists of the galanin GAL3 receptor. One example,…”
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Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility by KONKEL, Michael J, PACKIARAJAN, Mathivanan, HEIDI CHEN, TOPIWALA, Upendra P, JIMENEZ, Hermogenes, TALISMAN, Ian Jamie, COATE, Heather, WALKER, Mary W

“…A series of amino analogs of 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (1) were synthesized to improve aqueous solubility, while…”
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Synthesis and Structure−Activity Relationship of Fluoro Analogues of 8-{2-[4-(4-Methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as Selective α1d-Adrenergic Receptor Antagonists by Konkel, Michael J, Wetzel, John M, Cahir, Marie, Craig, Douglas A, Noble, Stewart A, Gluchowski, Charles

“…We have discovered high-affinity antagonists (exemplified by 11 and 12) that are the most selective for α1d-adrenergic receptors (α1d-AR) reported to date. In…”
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Palladium-Catalyzed Allylic Coupling of 1,2,3-Triazolo[4,5-d]pyrimidines (8-Azapurines) by Konkel, Michael J, Vince, Robert

“…The palladium-catalyzed coupling of the sodium salt of 7-amino-1,2,3-triazolo[4,5-d]pyrimidine (8-azaadenine, 1) with allylic phosphates or carbonates resulted…”
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Structure Determination of the Products from the Acid-Catalyzed Condensation of Indole with Acetone by Noland, Wayland E, Konkel, Michael J, Konkel, Lisa M. C, Pearce, Bradley C, Barnes, Charles L, Schlemper, Elmer O

“…Four of the previously reported compounds obtained from the acid-catalyzed condensation of indole with acetone are now assigned the following structures: …”
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Synthesis and Structure−Activity Relationship of Fluoro Analogues of 8-{2-[4-(4-Methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as Selective α 1d -Adrenergic Receptor Antagonists by Konkel, Michael J., Wetzel, John M., Cahir, Marie, Craig, Douglas A., Noble, Stewart A., Gluchowski, Charles

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Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists by Konkel, Michael J, Wetzel, John M, Cahir, Marie, Craig, Douglas A, Noble, Stewart A, Gluchowski, Charles

“…We have discovered high-affinity antagonists (exemplified by 11 and 12) that are the most selective for alpha(1d)-adrenergic receptors (alpha(1d)-AR) reported…”
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Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal 3 receptor binding affinity and improved solubility by Konkel, Michael J., Packiarajan, Mathivanan, Chen, Heidi, Topiwala, Upendra P., Jimenez, Hermogenes, Talisman, Ian Jamie, Coate, Heather, Walker, Mary W.

“…A series of amino analogs of 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2 H-indol-2-one ( 1) were synthesized to improve aqueous solubility,…”
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Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal sub(3) receptor binding affinity and improved solubility by Konkel, Michael J, Packiarajan, Mathivanan, Chen, Heidi, Topiwala, Upendra P, Jimenez, Hermogenes, Talisman, Ian Jamie, Coate, Heather, Walker, Mary W

“…A series of amino analogs of 1,3-dihydro-1-phenyl-3-[[3- (trifluoromethyl)phenyl]imino]-2H-indol-2-one (1) were synthesized to improve aqueous solubility,…”
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3-Arylimino-2-indolones Are Potent and Selective Galanin GAL 3 Receptor Antagonists by Konkel, Michael J., Lagu, Bharat, Boteju, Lakmal W., Jimenez, Hermogenes, Noble, Stewart, Walker, Mary W., Chandrasena, Gamini, Blackburn, Thomas P., Nikam, Sham S., Wright, Jon L., Kornberg, Brian E., Gregory, Tracy, Pugsley, Thomas A., Akunne, Hyacinth, Zoski, Kim, Wise, Lawrence D.

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3-arylimino-2-indolones are potent and selective galanin GAL3receptor antagonists by KONKEL, Michael J, LAGU, Bharat, KORNBERG, Brian E, GREGORY, Tracy, PUGSLEY, Thomas A, AKUNNE, Hyacinth, ZOSKI, Kim, WISE, Lawrence D, BOTEJU, Lakmal W, JIMENEZ, Hermogenes, NOBLE, Stewart, WALKER, Mary W, CHANDRASENA, Gamini, BLACKBURN, Thomas P, NIKAM, Sham S, WRIGHT, Jon L

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Cyclohexenyl nucleosides: Synthesis of cis-4-(9 H-purin-9-yl)-2-cyclohexenylcarbinols by Konkel, Michael J., Vince, Robert

“…Syntheses of the title compounds were accomplished in 6–7 steps, starting from cyclohexadiene and chlorosulphonyl isocyanate. The key step of the strategy…”
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Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal 3 ) antagonists SNAP 37889 and SNAP 398299 (vol 102, pg 14789, 2005) by Swanson, CJ, Blackburn, TP, Zhang, XX, Zheng, K, Xu, ZQD, Hokfelt, T, Wolinsky, TD, Konkel, MJ, Chen, HD, Zhong, HL, Walker, MW, Craig, DA, Gerald, CPG, Branchek, TA

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Cyclohexenyl nucleosides: Synthesis and biological activity of trans-3-(purin-9-yl)-4-cyclohexenylcarbinols by Konkel, Michael J., Vince, Robert

“…The primary alcohol of cis-3-hydroxy-4-cyclohexenylcarbinol was protected with a silyl group and then the configuration of the secondary alcohol was inverted…”
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In situ vinylindole synthesis. Diels-Alder reactions with maleic anhydride and maleic acid to give tetrahydrocarbazoles and carbazoles by Noland, Wayland E., Xia, Guang-Ming, Gee, Kyle R., Konkel, Michael J., Wahlstrom, Mary J., Condoluci, John J., Rieger, Dale L.

“…Tetrahydrocarbazoles have been prepared in one-flask syntheses from indoles, ketones, and maleic anhydride, with acid catalysis. The reactions involve a…”
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The crystal structure of a novel product from the acid-catalyzed condensation of 1-benzylindole with acetone by NOLAND, W. E, KONKEL, M. J, FANBURG, S. J, VENKATRAMAN, S, BRITTON, D

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In situ vinylindole synthesis. Diels-alder reactions with maleimides to give tetrahydrocarbazoles by Noland, Wayland E., Walhstrom, Mary J., Konkel, Michael J., Brigham, Mark E., Trowbridge, Annette G., Konkel, Lisa M. C., Gourneau, Ronald P., Scholten, Cheryl A., Lee, Nina H., Condoluci, John J., Gac, Todd S., Pour, Mehrdad Mostafaei, Radford, Peter M.

“…Tetrahydrocarbazoles have been prepared in one‐flask syntheses from indoles, ketones or aldehydes, and maleimides, with acid catalysis. The reactions involve a…”
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Diels-alder reactions of 3-(2-nitrovinyl)indoles: Formation of carbazoles and bridged carbazoles by Noland, Wayland E., Konkel, Michael J., Tempesta, Michael S., Cink, Russell D., Powers, Dawn M., Schlemper, Elmer O., Barnes, Charles L.

“…The Diels‐Alder reactions of 1‐substituted‐3‐(2‐nitrovinyl)indoles 3 with quinones and acetylenes give aromatized 1:1 adducts (‐ nitrous acid) (1) or (‐…”
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