Depressant Effect of Trapidil on Dog Coronary Arterial Contraction Induced by Ergonovine

Depressant Effect of Trapidil on Dog Coronary Arterial Contraction Induced by Ergonovine

Effects of trapidil on ergonovine-induced contractions of isolated dog coronary arteries were investigated in vitro. Ergonovine produced dosedependent contractions of helical strips cut from the left circumflex branches of coronary arteries. Trapidil significantly depressed thesecontractions. 5-HT a...

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Bibliographic Details
Published in:Japanese Heart Journal Vol. 22; no. 3; pp. 413 - 419
Main Authors: SAKANASHI, Matao, YOSHIKAWA, Yushi, KONDOH, Genzo, YONEMURA, Ken-ichi
Format: Journal Article
Language:English
Published: Japan International Heart Journal Association 01-01-1981
Subjects:
5-HT receptor
Adrenergic alpha receptor
Animals
Arteries - drug effects
Coronary arterial contraction
Coronary Vessels - drug effects
Dogs
Dose-Response Relationship, Drug
Ergonovine
Ergonovine - antagonists & inhibitors
Ergonovine - pharmacology
In Vitro Techniques
Norepinephrine - pharmacology
Pyrimidines - pharmacology
Rabbits
Trapidil
Trapidil - pharmacology
Vasoconstriction - drug effects
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Summary:Effects of trapidil on ergonovine-induced contractions of isolated dog coronary arteries were investigated in vitro. Ergonovine produced dosedependent contractions of helical strips cut from the left circumflex branches of coronary arteries. Trapidil significantly depressed thesecontractions. 5-HT also produced dose-dependent contractions of the strips, which were depressed by trapidil. In isolated rabbit femoral arterial preparations, norepinephrine dose-dependently contracted the strips. Phentolamine significantly depressed these contractions, and trapidil depressed them when relatively high doses were applied previously. Results indicate that trapidil has a depressant effect on coronary arterial contractions induced by ergonovine, partly through antagonism to 5-HT receptor and/or adrenergic alpha receptor.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-4868
1348-673X
DOI:10.1536/ihj.22.413