Search Results - "KONDO, TADASHI"

Cancer biomarker development and two-dimensional difference gel electrophoresis (2D-DIGE) by Kondo, Tadashi

“…Cancer results from the accumulation of genomic alterations. As the genome is functionally translated to the proteome and regulates tumor cell behavior,…”
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Current status and future outlook for patient‐derived cancer models from a rare cancer research perspective by Kondo, Tadashi

“…Rare cancers are a group of approximately 200 malignancies with extremely low incidences and with a wide variety of genotypes and phenotypes. Collectively,…”
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Inconvenient truth: Cancer biomarker development by using proteomics by Kondo, Tadashi

“…A biomarker is a crucial tool for measuring the progress of disease and the effects of treatment for better clinical outcomes in cancer patients. Diagnostic,…”
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Current status and perspectives of patient-derived rare cancer models by Kondo, Tadashi

“…Malignancies with extremely low incidences, such as less than 6 per 100,000 people annually, are defined as rare cancers. Approximately 200 malignancies are…”
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Current Status of Proteomics in Ewing's Sarcoma by Kondo, Tadashi

“…Ewing's sarcoma is an extremely rare mesenchymal malignancy of the bone, which predominantly occurs in children and young adolescents. Ewing's sarcoma is…”
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Proteogenomics for the Study of Gastrointestinal Stromal Tumors by Kondo, Tadashi

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Gain-of-function mutations in KIT or…”
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Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer by Shirakihara, Takuya, Yamaguchi, Hideki, Kondo, Tadashi, Yashiro, Masakazu, Sakai, Ryuichi

“…Diffuse-type gastric cancer (DGC) is a highly invasive subtype of gastric adenocarcinoma that frequently exhibits scattered peritoneal metastasis. Previous…”
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A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes by Asano, Naofumi, Matsuzaki, Juntaro, Ichikawa, Makiko, Kawauchi, Junpei, Takizawa, Satoko, Aoki, Yoshiaki, Sakamoto, Hiromi, Yoshida, Akihiko, Kobayashi, Eisuke, Tanzawa, Yoshikazu, Nakayama, Robert, Morioka, Hideo, Matsumoto, Morio, Nakamura, Masaya, Kondo, Tadashi, Kato, Ken, Tsuchiya, Naoto, Kawai, Akira, Ochiya, Takahiro

“…Due to their rarity and diversity, sarcomas are difficult to diagnose. Consequently, there is an urgent demand for a novel diagnostic test for these cancers…”
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CDK1 dependent phosphorylation of hTERT contributes to cancer progression by Yasukawa, Mami, Ando, Yoshinari, Yamashita, Taro, Matsuda, Yoko, Shoji, Shisako, Morioka, Masaki Suimye, Kawaji, Hideya, Shiozawa, Kumiko, Machitani, Mitsuhiro, Abe, Takaya, Yamada, Shinji, Kaneko, Mika K., Kato, Yukinari, Furuta, Yasuhide, Kondo, Tadashi, Shirouzu, Mikako, Hayashizaki, Yoshihide, Kaneko, Shuichi, Masutomi, Kenkichi

“…The telomerase reverse transcriptase is upregulated in the majority of human cancers and contributes directly to cell transformation. Here we report that hTERT…”
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Extensive iron–water exchange at Earth’s core–mantle boundary can explain seismic anomalies by Kawano, Katsutoshi, Nishi, Masayuki, Kuwahara, Hideharu, Kakizawa, Sho, Inoue, Toru, Kondo, Tadashi

“…Seismological observations indicate the presence of chemical heterogeneities at the lowermost mantle, just above the core–mantle boundary (CMB), sparking…”
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Establishment and characterization of NCC-CDS2-C1: a novel patient-derived cell line of CIC-DUX4 sarcoma by Yoshimatsu, Yuki, Noguchi, Rei, Tsuchiya, Ryuto, Kito, Fusako, Sei, Akane, Sugaya, Jun, Nakagawa, Makoto, Yoshida, Akihiko, Iwata, Shintaro, Kawai, Akira, Kondo, Tadashi

“…CIC - DUX4 sarcoma (CDS), an aggressive soft tissue sarcoma, is characterized by a CIC and DUX4 rearrangement. It has a dismal clinical course and high…”
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Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics by Kondo, Tadashi, Hirohashi, Setsuo

“…Proteome data combined with histopathological information provides important, novel clues for understanding cancer biology and reveals candidates for tumor…”
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Casting doubt on the traditional approach of cancer biomarker discovery through proteomics by Kondo, Tadashi

“…Towards revolutionary biomarkers, a considerable amount of research funds and time have been dedicated to proteomics. Although the discovery of novel…”
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Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system by Arai, Kazuya, Sakamoto, Ruriko, Kubota, Daisuke, Kondo, Tadashi

“…Chemoresistance is one of the most critical prognostic factors in osteosarcoma, and elucidation of the molecular backgrounds of chemoresistance may lead to…”
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Establishment and characterization of NCC-MFS2-C1: a novel patient-derived cancer cell line of myxofibrosarcoma by Noguchi, Rei, Yoshimatsu, Yuki, Ono, Takuya, Sei, Akane, Hirabayashi, Kaoru, Ozawa, Iwao, Kikuta, Kazutaka, Kondo, Tadashi

“…Myxofibrosarcoma (MFS) is among the most aggressive and complex sarcoma types that require novel therapeutic approaches for improved clinical outcomes. MFS…”
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Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan™) platform by Qiao, Zhiwei, Pan, Xiaoqing, Parlayan, Cuneyd, Ojima, Hidenori, Kondo, Tadashi

“…Vascular invasion is a pathological hallmark of hepatocellular carcinoma (HCC), associated with poor prognosis; it is strongly related to the early recurrence…”
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Establishment and characterization of the NCC-GCTB4-C1 cell line: a novel patient-derived cell line from giant cell tumor of bone by Ono, Takuya, Noguchi, Rei, Yoshimatsu, Yuki, Tsuchiya, Ryuto, Sin, Yooksil, Nakagawa, Rumi, Hirabayashi, Kaoru, Ozawa, Iwao, Kikuta, Kazutaka, Kondo, Tadashi

“…Giant cell tumor of bone (GCTB) is a rare osteolytic intermediate bone tumor that harbors a pathogenic H3F3A gene mutation and exhibits characteristic…”
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Establishment and characterization of NCC-GCTB1-C1: a novel patient-derived cancer cell line of giant cell tumor of bone by Noguchi, Rei, Yoshimatsu, Yuki, Ono, Takuya, Sei, Akane, Hirabayashi, Kaoru, Ozawa, Iwao, Kikuta, Kazutaka, Kondo, Tadashi

“…Giant cell tumor of bone (GCTB) is a rare osteolytic bone tumor, accounting for approximately 5% of all primary bone tumors. GCTB is characterized by unique…”
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Establishment and characterization of NCC-MFS4-C1: a novel patient-derived cell line of myxofibrosarcoma by Yoshimatsu, Yuki, Noguchi, Rei, Tsuchiya, Ryuto, Sin, Yooksil, Ono, Takuya, Sugaya, Jun, Iwata, Shintaro, Yoshida, Akihiko, Kawai, Akira, Kondo, Tadashi

“…Myxofibrosarcoma (MFS) is an aggressive sarcoma with a highly complex karyotype. Complete resection is the only curative treatment for MFS because it is…”
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Establishment and characterization of NCC-GCTB5-C1: a novel cell line of giant cell tumor of bone by Akiyama, Taro, Yoshimatsu, Yuki, Noguchi, Rei, Sin, Yooksil, Tsuchiya, Ryuto, Ono, Takuya, Fukushima, Suguru, Toda, Yu, Kojima, Naoki, Yoshida, Akihiko, Ohtori, Seji, Kawai, Akira, Kondo, Tadashi

“…Giant cell tumor of bone (GCTB), is a rare intermediate malignant bone tumor with high local infiltrative ability, and is genetically characterized by mutation…”
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