Search Results - "KON, Yasuhiro"

Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo by Younis, Mahmoud A., Khalil, Ikramy A., Elewa, Yaser H.A., Kon, Yasuhiro, Harashima, Hideyoshi

“…Hepatocellular carcinoma (HCC) is a fatal disease with limited therapeutic choices. The stroma-rich tumor microenvironment hinders the in vivo delivery of most…”
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Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis by Younis, Mahmoud A., Sato, Yusuke, Elewa, Yaser H.A., Kon, Yasuhiro, Harashima, Hideyoshi

“…Herein, we report on the development of a platform for the selective delivery of mRNA to the hard-to-transfect Activated Hepatic Stellate Cells (aHSCs), the…”
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Effects of autoimmune abnormalities on skeletal muscle regeneration after needle puncture in mice by Masugi, Misato, Ichii, Osamu, Otani, Yuki, Namba, Takashi, Kon, Yasuhiro

“…Regeneration of injured skeletal muscles is supported by the activation of satellite cells, and excessive traumatic injuries may trigger abnormal processes,…”
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Phenotypes of streptozotocin-induced gestational diabetes mellitus in mice by Takahashi, Narumi, Ichii, Osamu, Hiraishi, Masaya, Namba, Takashi, Otani, Yuki, Nakamura, Teppei, Kon, Yasuhiro

“…Gestational diabetes mellitus (GDM) in human patients disrupts glucose metabolism post-pregnancy, affecting fetal development. Although obesity and genetic…”
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Decreased miR-26a expression correlates with the progression of podocyte injury in autoimmune glomerulonephritis by Ichii, Osamu, Otsuka-Kanazawa, Saori, Horino, Taro, Kimura, Junpei, Nakamura, Teppei, Matsumoto, Manabu, Toi, Makoto, Kon, Yasuhiro

“…MicroRNAs contribute to the pathogenesis of certain diseases and may serve as biomarkers. We analyzed glomerular microRNA expression in B6.MRLc1, which serve…”
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Immune-associated renal disease found in caspase 3-deficient mice by Suzuki, Takashi, Ichii, Osamu, Nakamura, Teppei, Horino, Taro, Elewa, Yaser Hosny Ali, Kon, Yasuhiro

“…Caspase (CASP) 3 is known as a representative effector CASP of apoptosis and recently as a mediator in inflammatory cell death called pyroptosis…”
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Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer by Abd Elwakil, Mahmoud M., Khalil, Ikramy A., Elewa, Yaser H. A., Kusumoto, Kenji, Sato, Yusuke, Shobaki, Nour, Kon, Yasuhiro, Harashima, Hideyoshi

“…The development of efficient gene delivery systems targeting the lung endothelium remains a serious challenge. This study reports on the design and…”
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Effects of autoimmune abnormalities on fertility and placental morphology in mice by Yamanaka, Risa, Ichii, Osamu, Nakamura, Teppei, Otani, Yuki, Namaba, Takashi, Kon, Yasuhiro

“…Autoimmune diseases (AIDs) alter the placental immune environment leading to fetal loss. This study investigated the effects of AIDs on pregnancy and the…”
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Close Association between Altered Urine-Urothelium Barrier and Tertiary Lymphoid Structure Formation in the Renal Pelvis during Nephritis by Ichii, Osamu, Hosotani, Marina, Masum, Md Abdul, Horino, Taro, Otani, Yuki, Namba, Takashi, Nakamura, Teppei, Hosny Ali, Elewa Yaser, Kon, Yasuhiro

“…Kidneys with chronic inflammation develop tertiary lymphoid structures (TLSs). Infectious pyelonephritis is characterized by renal pelvis (RP) inflammation…”
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Dual Effect of Bleomycin on Histopathological Features of Lungs and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model by Elewa, Yaser Hosny Ali, Ichii, Osamu, Nakamura, Teppei, Kon, Yasuhiro

“…Mediastinal fat-associated lymphoid clusters (MFALCs) are novel immune clusters that function in the pathogenesis of bleomycin (BLM)-induced pneumonitis in a…”
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Compartmentalization of interleukin 36 subfamily according to inducible and constitutive expression in the kidneys of a murine autoimmune nephritis model by Namba, Takashi, Ichii, Osamu, Nakamura, Teppei, Masum, Md. Abdul, Otani, Yuki, Hosotani, Marina, Elewa, Yaser Hosny Ali, Kon, Yasuhiro

“…The interleukin (IL) 36 subfamily belongs to the IL-1 family and is comprised of agonists (IL-36α, IL-36β, IL-36γ) and antagonists (IL-36Ra, IL-38). We…”
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Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand by Ichii, Osamu, Otsuka-Kanazawa, Saori, Nakamura, Teppei, Ueno, Masaaki, Kon, Yasuhiro, Chen, Weiping, Rosenberg, Avi Z, Kopp, Jeffrey B

“…Indoxyl sulfate is a uremic toxin and a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator. Elevated serum indoxyl sulfate levels may…”
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Lipidomic study of kidney in a mouse model with urine flow obstruction by Gowda, Divyavani, Masum, Md. Abdul, B. Gowda, Siddabasave Gowda, Shekhar, Chandra, Rubel, Md. Zahir Uddin, Kira, Shunnosuke, Ichii, Osamu, Kon, Yasuhiro, Chiba, Hitoshi, Hui, Shu-Ping

“…Obstructed urine flow is known to cause structural and functional kidney damage leading to renal fibrosis. However, limited information is available on the…”
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Altered ciliary morphofunction in the oviductal infundibulum of systemic autoimmune disease-prone MRL/MpJ-Faslpr/lpr mice by Hosotani, Marina, Ichii, Osamu, Nakamura, Teppei, Masum, Md. Abdul, Otani, Yuki, Elewa, Yaser Hosny Ali, Kon, Yasuhiro

“…According to our previous reports, impaired oocyte pickup was observed in the oviductal infundibulum of an autoimmune disease (AD) mouse model, suggesting a…”
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Comparative analysis of mediastinal fat‐associated lymphoid cluster development and lung cellular infiltration in murine autoimmune disease models and the corresponding normal control strains by Elewa, Yaser Hosny Ali, Ichii, Osamu, Kon, Yasuhiro

“…Summary We previously discovered mediastinal fat‐associated lymphoid clusters (MFALCs) as novel lymphoid clusters associated with mediastinal fat tissue in…”
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Modified foreign body reaction to silicone imbedded in subcutaneous tissues by different mouse systemic immune conditions by Yamakawa, Tomohiro, Ichii, Osamu, Nakamura, Teppei, Namba, Takashi, Elewa, Yaser Hosny Ali, Masum, Md. Abdul, Otani, Yuki, Nishimura, Takanori, Kon, Yasuhiro

“…Foreign body reaction (FBR) causes unexpected adverse effects due to implanted materials in humans and animals. Inflammation and subsequent fibrosis during FBR…”
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Podocyte Injury Through Interaction Between Tlr8 and Its Endogenous Ligand miR-21 in Obstructed and Its Collateral Kidney by Masum, Md Abdul, Ichii, Osamu, Elewa, Yaser Hosny Ali, Kon, Yasuhiro

“…While chronic kidney disease is prevalent in adults, obstructive nephropathy (ON) has been reported in both young and old patients. In ON, tubulointerstitial…”
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Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone by Oe, Sao, Masum, Md. Abdul, Ichii, Osamu, Nishimura, Takanori, Nakamura, Teppei, Namba, Takashi, Otani, Yuki, Nakayama, Yasuhide, Elewa, Yaser Hosny Ali, Kon, Yasuhiro

“…We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue…”
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Vasculature-Associated Lymphoid Tissue: A Unique Tertiary Lymphoid Tissue Correlates With Renal Lesions in Lupus Nephritis Mouse Model by Masum, Md Abdul, Ichii, Osamu, Elewa, Yaser Hosny Ali, Otani, Yuki, Namba, Takashi, Kon, Yasuhiro

“…Lupus nephritis (LN) is a common complication in young patients and the most predominant cause of glomerulonephritis. Infiltrating immune cells and presence of…”
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BXSB/MpJ-Yaa mouse model of systemic autoimmune disease shows increased apoptotic germ cells in stage XII of the seminiferous epithelial cycle by Otani, Yuki, Ichii, Osamu, Masum, Md. Abdul, Kimura, Junpei, Nakamura, Teppei, Elewa, Yaser Hosny Ali, Kon, Yasuhiro

“…In mammals, the reproductive system and autoimmunity regulate mutual functions. Importantly, systemic autoimmune diseases are thought to cause male infertility…”
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