Search Results - "KON, Tomoya"

Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases by Kon, Tomoya, Tomiyama, Masahiko, Wakabayashi, Koichi

“…Lewy body disease (LBD) is characterized by the presence of Lewy bodies (LBs) and Lewy neurites and comprises a diagnostic spectrum that includes Parkinson's…”
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Autophagy Is a Common Degradation Pathway for Bunina Bodies and TDP-43 Inclusions in Amyotrophic Lateral Sclerosis by Mori, Fumiaki, Miki, Yasuo, Kon, Tomoya, Tanji, Kunikazu, Wakabayashi, Koichi

“…Abstract Bunina bodies (BBs) coexisting with TDP-43-immunoreactive (TDP-43-IR) skein-like inclusions (SIs) and round inclusions (RIs) in lower motor neurons…”
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Cabergoline, a long-acting dopamine agonist, attenuates L-dopa-induced dyskinesia without L-dopa sparing in a rat model of Parkinson’s disease by Nishijima, Haruo, Mori, Fumiaki, Kimura, Tamaki, Miki, Yasuo, Kinoshita, Iku, Nakamura, Takashi, Kon, Tomoya, Suzuki, Chieko, Wakabayashi, Koichi, Tomiyama, Masahiko

“…Intermittent administration of L-dopa in Parkinson’s disease is associated with L-dopa-induced dyskinesia (LID). Long-acting dopamine agonists may reduce the…”
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Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin-Proteasome Pathways in Lewy Body Disease by Kon, Tomoya, Lee, Seojin, Martinez-Valbuena, Ivan, Yoshida, Koji, Tanikawa, Satoshi, Lang, Anthony E, Kovacs, Gabor G

“…Lewy body diseases (LBDs) feature α-synuclein (α-syn)-containing Lewy bodies, with misfolded α-syn potentially propagating as seeds. Using a seeding…”
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SNCA and TPPP transcripts increase in oligodendroglial cytoplasmic inclusions in multiple system atrophy by Kon, Tomoya, Forrest, Shelley L., Lee, Seojin, Li, Jun, Chasiotis, Helen, Nassir, Nasna, Uddin, Mohammed J., Lang, Anthony E., Kovacs, Gabor G.

“…Multiple system atrophy (MSA) is characterized by glial cytoplasmic inclusions (GCIs) containing aggregated α-synuclein (α-syn) in oligodendrocytes. The origin…”
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Immunoreactivity of myelin‐associated oligodendrocytic basic protein in Lewy bodies by Kon, Tomoya, Tanji, Kunikazu, Mori, Fumiaki, Kimura, Akari, Kakita, Akiyoshi, Wakabayashi, Koichi

“…Myelin‐associated oligodendrocytic basic protein (MOBP) plays a role in structural maintenance of the myelin sheath in the central nervous system. Recent…”
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Accumulation of Nonfibrillar TDP-43 in the Rough Endoplasmic Reticulum Is the Early-Stage Pathology in Amyotrophic Lateral Sclerosis by Kon, Tomoya, Mori, Fumiaki, Tanji, Kunikazu, Miki, Yasuo, Nishijima, Haruo, Nakamura, Takashi, Kinoshita, Iku, Suzuki, Chieko, Kurotaki, Hidekachi, Tomiyama, Masahiko, Wakabayashi, Koichi

“…Abstract Transactivation response DNA-binding protein 43 (TDP-43)-immunoreactive neuronal cytoplasmic inclusions (NCIs) are the histopathological hallmarks of…”
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Assessing the relationship between non-motor symptoms and health-related quality of life in Parkinson’s disease: a retrospective observational cohort study by Ueno, Tatsuya, Kon, Tomoya, Haga, Rie, Nishijima, Haruo, Arai, Akira, Tomiyama, Masahiko

“…Objectives Non-motor symptoms (NMSs) negatively impact the health-related quality of life (HrQOL) of patients with Parkinson’s disease (PD). The Movement…”
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GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming by Nishijima, Haruo, Mori, Fumiaki, Arai, Akira, Zhu, Gang, Wakabayashi, Koichi, Okada, Motohiro, Ueno, Shinya, Ichinohe, Noritaka, Suzuki, Chieko, Kon, Tomoya, Tomiyama, Masahiko

“…Levo-dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease; however, most patients develop uncontrollable abnormal…”
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Axon terminal hypertrophy of striatal projection neurons with levodopa-induced dyskinesia priming by Nakamura, Takashi, Nishijima, Haruo, Mori, Fumiaki, Kinoshita, Iku, Kon, Tomoya, Suzuki, Chieko, Wakabayashi, Koichi, Tomiyama, Masahiko

“…A rat model of levodopa-induced dyskinesia (LID) showed enlarged axon terminals of striatal direct pathway neurons in the internal segment of the globus…”
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Myelin Oligodendrocyte Glycoprotein-IgG-positive Recurrent Bilateral Optic Papillitis with Serous Retinal Detachment by Kon, Tomoya, Hikichi, Hiroki, Ueno, Tatsuya, Suzuki, Chieko, Nunomura, Jinichi, Kaneko, Kimihiko, Takahashi, Toshiyuki, Nakashima, Ichiro, Tomiyama, Masahiko

“…Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been detected in inflammatory demyelinating central nervous system diseases. A…”
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Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model by Nishijima, Haruo, Suzuki, Satoko, Kon, Tomoya, Funamizu, Yukihisa, Ueno, Tatsuya, Haga, Rie, Suzuki, Chihiro, Arai, Akira, Kimura, Tamaki, Suzuki, Chieko, Meguro, Reiko, Miki, Yasuo, Yamada, Junko, Migita, Keisuke, Ichinohe, Noritaka, Ueno, Shinya, Baba, Masayuki, Tomiyama, Masahiko

“…ABSTRACT Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa‐induced dyskinesia. Recently, it has been…”
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Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases by Miki, Yasuo, Mori, Fumiaki, Kon, Tomoya, Tanji, Kunikazu, Toyoshima, Yasuko, Yoshida, Mari, Sasaki, Hidenao, Kakita, Akiyoshi, Takahashi, Hitoshi, Wakabayashi, Koichi

“…The sigma‐1 receptor (SIGMAR1) is now known to be one of the endoplasmic reticulum (ER) chaperones, which participate in the degradation of misfolded proteins…”
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Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions by Mori, Fumiaki, Tada, Mari, Kon, Tomoya, Miki, Yasuo, Tanji, Kunikazu, Kurotaki, Hidekachi, Tomiyama, Masahiko, Ishihara, Tomohiko, Onodera, Osamu, Kakita, Akiyoshi, Wakabayashi, Koichi

“…Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial…”
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An autopsy case of amyotrophic lateral sclerosis with striatonigral and pallidoluysian degeneration and cat's‐eye‐shaped neuronal nuclear inclusions by Kon, Tomoya, Mori, Fumiaki, Kinoshita, Iku, Nakamura, Takashi, Nishijima, Haruo, Suzuki, Chieko, Goto, Shintaro, Kijima, Hiroshi, Tomiyama, Masahiko, Wakabayashi, Koichi

“…We report the case of a Japanese woman with sporadic amyotrophic lateral sclerosis (ALS) of 28 months’ duration who died at the age of 66 years. Postmortem…”
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Pathological substrate of memory impairment in multiple system atrophy by Miki, Yasuo, Tanji, Kunikazu, Shinnai, Kana, Tanaka, Makoto T., Altay, Firat, Foti, Sandrine C., Strand, Catherine, Sasaki, Takanori, Kon, Tomoya, Shimoyama, Shuji, Furukawa, Tomonori, Nishijima, Haruo, Yamazaki, Hiromi, Asi, Yasmine T., Bettencourt, Conceição, Jaunmuktane, Zane, Tada, Mari, Mori, Fumiaki, Mizukami, Hiroki, Tomiyama, Masahiko, Lashuel, Hilal A., Lashley, Tammaryn, Kakita, Akiyoshi, Ling, Helen, Lees, Andrew J., Holton, Janice L., Warner, Thomas T., Wakabayashi, Koichi

“…Aims Synaptic dysfunction in Parkinson's disease is caused by propagation of pathogenic α‐synuclein between neurons. Previously, in multiple system atrophy…”
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An autopsy case of early‐stage amyotrophic lateral sclerosis with TDP‐43 immunoreactive neuronal, but not glial, inclusions by Kon, Tomoya, Mori, Fumiaki, Oyama, Yoshinobu, Tanji, Kunikazu, Kimura, Tamaki, Takahashi, Shirushi, Wakabayashi, Koichi

“…Phosphorylated transactivation response DNA‐binding protein 43 kDa (p‐TDP‐43)‐immunoreactive neuronal and glial cytoplasmic inclusions are a histopathological…”
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A Long Interval from a Spinal Cord Lesion to a Subsequent Brain Lesion in Primary Central Nervous System Vasculitis by Kon, Tomoya, Funamizu, Yukihisa, Suzuki, Chieko, Sato, Tsugumi, Kurotaki, Hidekachi, Kurihara, Aiichiro, Kurose, Akira, Wakabayashi, Koichi, Tomiyama, Masahiko

“…Primary central nervous system vasculitis (PCNSV) is an uncommon vasculitis restricted to the small- and medium-sized vessels in the brain and spinal cord…”
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Neuronal SNCA transcription during Lewy body formation by Kon, Tomoya, Forrest, Shelley L., Lee, Seojin, Martinez‑Valbuena, Ivan, Li, Jun, Nassir, Nasna, Uddin, Mohammed J., Lang, Anthony E., Kovacs, Gabor G.

“…Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage…”
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Unilateral Oculomotor Nerve Palsy Following Campylobacter Infection: A Mild Form of Miller Fisher Syndrome without Ataxia by Ueno, Tatsuya, Kon, Tomoya, Kurihara, Ai-ichiro, Tomiyama, Masahiko

“…Unilateral oculomotor nerve palsy can result from various neurological disorders. We herein report the case of a 68-year-old man with complete unilateral…”
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