Search Results - "KOMURA, Takuya"

Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis by Ho, Tuyen Thuy Bich, Nasti, Alessandro, Seki, Akihiro, Komura, Takuya, Inui, Hiiro, Kozaka, Takashi, Kitamura, Yoji, Shiba, Kazuhiro, Yamashita, Taro, Yamashita, Tatsuya, Mizukoshi, Eishiro, Kawaguchi, Kazunori, Wada, Takashi, Honda, Masao, Kaneko, Shuichi, Sakai, Yoshio

“…BackgroundPancreatic ductular adenocarcinoma (PDAC) is among the most dreadful of malignancies, in part due to the lack of efficacious chemotherapy. Immune…”
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Distinct chemotherapy‐associated anti‐cancer immunity by myeloid cells inhibition in murine pancreatic cancer models by Sakai, Yoshio, Miyazawa, Masaki, Komura, Takuya, Yamada, Takeshi, Nasti, Alessandro, Yoshida, Keiko, Takabatake, Hisashi, Yamato, Masatoshi, Yamashita, Taro, Yamashita, Tatsuya, Mizukoshi, Eishiro, Okuzono, Mai, Ho, Tuyen Thuy Bich, Kawaguchi, Kazunori, Wada, Takashi, Honda, Masao, Kaneko, Shuichi

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy associated with an extremely poor prognosis. Chemotherapy, such as gemcitabine (GEM), is the…”
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A rare cause of jejunal perforation: Monomorphic epitheliotropic intestinal T‐cell lymphoma by Yanagi, Masahiro, Komura, Takuya, Kagaya, Takashi

“…Monomorphic epitheliotropic intestinal T‐cell lymphoma (MEITL) is a very rare intestinal T‐cell lymphoma which is observed most frequently in the jejunum…”
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Inflammatory features of pancreatic cancer highlighted by monocytes/macrophages and CD4+ T cells with clinical impact by Komura, Takuya, Sakai, Yoshio, Harada, Kenichi, Kawaguchi, Kazunori, Takabatake, Hisashi, Kitagawa, Hirohisa, Wada, Takashi, Honda, Masao, Ohta, Tetsuo, Nakanuma, Yasuni, Kaneko, Shuichi

“…Pancreatic ductal adenocarcinoma (PDAC) is among the most fatal of malignancies with an extremely poor prognosis. The objectives of this study were to provide…”
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Adipose tissue‐derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL‐17‐mediated inflammation by Yamato, Masatoshi, Sakai, Yoshio, Mochida, Hatsune, Kawaguchi, Kazunori, Takamura, Masayuki, Usui, Soichiro, Seki, Akihiro, Mizukoshi, Eishiro, Yamashita, Taro, Yamashita, Tatsuya, Ishida, Kousuke, Nasti, Alessandro, Tuyen, Ho Thuy Bich, Komura, Takuya, Yoshida, Keiko, Wada, Takashi, Honda, Masao, Kaneko, Shuichi

“…Background and Aim The pathological features of non‐alcoholic steatohepatitis (NASH) have not been determined, so fundamental treatment has not been…”
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The Serum Mac-2-binding Protein Glycosylation Isomer Dynamics in Acute Liver Injury by Seike, Takuya, Komura, Takuya, Shimizu, Yoshiaki, Omura, Hitoshi, Kumai, Tatsuo, Kagaya, Takashi, Ohta, Hajime, Kawashima, Atsuhiro, Harada, Kenichi, Kaneko, Shuichi, Unoura, Masashi

“…Objective We aimed to examine the dynamics of serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein glycosylation isomer (M2BPGi) in…”
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Management of biliary stricture in patients with IgG4-related sclerosing cholangitis by Miyazawa, Masaki, Takatori, Hajime, Kawaguchi, Kazunori, Kitamura, Kazuya, Arai, Kuniaki, Matsuda, Koichiro, Urabe, Takeshi, Inamura, Katsuhisa, Komura, Takuya, Mizuno, Hideki, Fuchizaki, Uichiro, Yamashita, Taro, Sakai, Yoshio, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Kaneko, Shuichi

“…We aimed to determine the optimal approach with endoscopic biliary drainage (EBD) and corticosteroid (CS) for the treatment of IgG4-related sclerosing…”
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Prognostic impact of clinical outcome after endoscopic gastroduodenal stent placement for malignant gastric outlet obstruction: a multicenter retrospective cohort study using a time-dependent analysis by Hodo, Yuji, Takatori, Hajime, Komura, Takuya, Asahina, Yoshiro, Chiba, Tomoyoshi, Takabatake, Hisashi, Hasatani, Kenkei, Nishino, Ryuhei, Yano, Masaaki, Takata, Yoshiko, Suda, Tsuyoshi, Shugo, Haruhiko, Nakanishi, Hiroyoshi, Yamada, Kazutoshi, Miwa, Kazuhiro, Kaji, Kiichiro, Nishitani, Masaki, Miyazawa, Masaki, Yamashita, Taro

“…Background: Endoscopic gastroduodenal stent (GDS) placement is widely used as a safe and effective method to rapidly improve gastrointestinal symptoms of…”
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Pancreatic acinar cell carcinoma with extension into the main pancreatic duct: a case report by Kayahara, Masato, Onishi, Ichiro, Makita, Naoki, Kano, Shunsuke, Munemoto, Masayoshi, Yagi, Yasumichi, Minami, Makiko, Orita, Noriaki, Komura, Takuya, Kurose, Nozomu

“…Background Pancreatic acinar cell carcinoma (PACC) is a rare exocrine malignant tumor. Its widespread intraductal extension into the main pancreatic duct (MPD)…”
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Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B by Kawaguchi, Kazunori, Honda, Masao, Ohta, Hajime, Terashima, Takeshi, Shimakami, Tetsuro, Arai, Kuniaki, Yamashita, Taro, Sakai, Yoshio, Yamashita, Tatsuya, Mizukoshi, Eishiro, Komura, Takuya, Unoura, Masashi, Kaneko, Shuichi

“…Background Hepatocellular carcinoma (HCC) occurs in chronic hepatitis B (CH-B) patients even after treatment with nucleos(t)ide analogues (NAs) by a mechanism…”
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Association of soluble T cell immunoglobulin domain and mucin-3 (sTIM-3) and mac-2 binding protein glycosylation isomer (M2BPGi) in patients with autoimmune hepatitis by Migita, Kiyoshi, Nakamura, Minoru, Aiba, Yoshihiro, Kozuru, Hideko, Abiru, Seigo, Komori, Atsumasa, Fujita, Yuya, Temmoku, Junpei, Asano, Tomoyuki, Sato, Shuzo, Furuya, Makiko, Naganuma, Atsushi, Yoshizawa, Kaname, Shimada, Masaaki, Ario, Keisuke, Mannami, Tomohiko, Kohno, Hiroshi, Kaneyoshi, Toshihiko, Komura, Takuya, Ohira, Hiromasa, Yatsuhashi, Hiroshi

“…Autoimmune hepatitis (AIH) is a disorder of unknown etiology in which immune-mediated liver injury progress to cirrhosis or hepatocellular carcinoma (HCC). The…”
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Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis by Tang, Yaliang, Masuo, Yusuke, Sakai, Yoshio, Wakayama, Tomohiko, Sugiura, Tomoko, Harada, Ryuichi, Futatsugi, Azusa, Komura, Takuya, Nakamichi, Noritaka, Sekiguchi, Hirotaka, Sutoh, Keita, Usumi, Koji, Iseki, Shoichi, Kaneko, Shuichi, Kato, Yukio

“…Xenobiotic transporters play key roles in disposition of certain therapeutic agents, although limited information is available on their roles other than…”
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Clinical Features and Resistance to Entecavir Monotherapy of Patients with Hepatitis B by Takayama, Hideo, Komura, Takuya, Kagaya, Takashi, Sugimoto, Saiho, Orita, Noriaki, Asahina, Yoshiro, Nishikawa, Masashi, Ohta, Hajime, Kaneko, Shuichi, Unoura, Masashi

“…Aim. Hepatitis B virus (HBV) infection is a major public health concern worldwide. Entecavir (ETV), a first-line nucleos(t)ide analogue (NA) for HBV, has a low…”
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Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma by Komura, Takuya, Takabatake, Hisashi, Harada, Kenichi, Yamato, Masatoshi, Miyazawa, Masaki, Yoshida, Keiko, Honda, Masao, Wada, Takashi, Kitagawa, Hirohisa, Ohta, Tetsuo, Kaneko, Shuichi, Sakai, Yoshio

“…Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy known, with an extremely poor prognosis due to the lack of an efficient diagnostic scheme…”
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Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice by Ishida, Kosuke, Seki, Akihiro, Kawaguchi, Kazunori, Nasti, Alessandro, Yamato, Masatoshi, Inui, Hiiro, Komura, Takuya, Yamashita, Taro, Arai, Kuniaki, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Wada, Takashi, Harada, Kenichi, Kaneko, Shuichi, Sakai, Yoshio

“…•Notch signaling is disrupted in non-alcoholic steatohepatitis (NASH) hepatocyte.•ADSCs express Notch ligands, namely JAG1, DLL1 and DLL4, on their cellular…”
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A Young Man with Non-alcoholic Steatohepatitis and Serum Anti-mitochondrial Antibody Positivity by Seike, Takuya, Komura, Takuya, Shimizu, Yoshiaki, Omura, Hitoshi, Kumai, Tatsuo, Kagaya, Takashi, Ohta, Hajime, Kawashima, Atsuhiro, Harada, Kenichi, Kaneko, Shuichi, Unoura, Masashi

“…A 37-year-old obese man who was a social drinker was admitted to our hospital to undergo a detailed examination for liver injury with anti-mitochondrial…”
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Phase I clinical study of liver regenerative therapy for cirrhosis by intrahepatic arterial infusion of freshly isolated autologous adipose tissue-derived stromal/stem (regenerative) cell by Sakai, Yoshio, Takamura, Masayuki, Seki, Akihiro, Sunagozaka, Hajime, Terashima, Takeshi, Komura, Takuya, Yamato, Masatoshi, Miyazawa, Masaki, Kawaguchi, Kazunori, Nasti, Alessandro, Mochida, Hatsune, Usui, Soichiro, Otani, Nobuhisa, Ochiya, Takahiro, Wada, Takashi, Honda, Masao, Kaneko, Shuichi

“…Adipose tissue stromal cells contain a substantial number of mesenchymal stem cells. As such, their application to regeneration of miscellaneous impaired…”
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Cytomegalovirus Reactivation Induced Acute Hepatitis and Gastric Erosions in a Patient with Rheumatoid Arthritis under Treatment with an Anti-IL-6 Receptor Antibody, Tocilizumab by Komura, Takuya, Ohta, Hajime, Nakai, Ryotaro, Seishima, Jun, Yamato, Masatoshi, Miyazawa, Masaki, Kaji, Kiichiro, Marukawa, Yohei, Kagaya, Takashi, Kitagawa, Kiyoki, Kawashima, Atsuhiro, Kaneko, Shuichi, Unoura, Masashi

“…Tocilizumab, an anti-human interleukin 6 receptor (IL-6R) monoclonal antibody, is widely used to treat rheumatoid arthritis (RA) and is expected to exhibit…”
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The Efficacy of Corticosteroid Therapy in a Patient with Non-alcoholic Steatohepatitis Overlapping Autoimmune Hepatitis by Komura, Takuya, Ohta, Hajime, Seike, Takuya, Shimizu, Yoshiaki, Nakai, Ryotaro, Omura, Hitoshi, Kagaya, Takashi, Kasashima, Satomi, Kawashima, Atsuhiro, Oba, Sakae, Harada, Kennichi, Kaneko, Shuichi, Unoura, Masashi

“…The overlap of multiple liver diseases can cause the disease activity and severity to worsen rapidly in some cases. We rarely see patients with non-alcoholic…”
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Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis by Nishikawa, Masashi, Kaneko, Shuichi, Unoura, Masashi, Orita, Noriaki, Nishino, Michiko, Sugimoto, Saiho, Yoshio, Takatoshi, Yanagi, Masahiro, Takayama, Hideo, Kagaya, Takashi, Komura, Takuya, Asahina, Yoshiro

“…Aim. Cytomegalovirus (CMV) can cause hepatitis, encephalomyelitis, and pneumonitis in immunocompromised patients. In contrast, CMV infection of immunocompetent…”
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