Search Results - "KOMOHARA, YOSHIHIRO"

Clinical significance of macrophage heterogeneity in human malignant tumors by Komohara, Yoshihiro, Jinushi, Masahisa, Takeya, Motohiro

“…The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known. With the recent introduction of the novel concept…”
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Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy by Komohara, Yoshihiro, Fujiwara, Yukio, Ohnishi, Koji, Takeya, Motohiro

“…The macrophage is known to be a multifunctional antigen presenting cells and playing a central role in inflammation. Macrophages infiltrate into malignant…”
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Role of tumor-associated macrophages in human malignancies: friend or foe? by Takeya, Motohiro, Komohara, Yoshihiro

“…Tumor‐associated macrophages (TAMs) play a pivotal role in tumor growth in human malignancies. Published studies have analyzed the relationship between TAM…”
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Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside by Jinushi, Masahisa, Komohara, Yoshihiro

“…Tumor-associated macrophages are a critical component of tumor microenvironments, which affect tumor growth, tumor angiogenesis, immune suppression, metastasis…”
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Possible functions of CD169‐positive sinus macrophages in lymph nodes in anti‐tumor immune responses by Komohara, Yoshihiro, Ohnishi, Koji, Takeya, Motohiro

“…The lymph node (LN) is an important immune system in which a number of antigen‐presenting cells are present that induce rapid immune responses to foreign…”
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Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma by Komohara, Yoshihiro, Hasita, Horlad, Ohnishi, Koji, Fujiwara, Yukio, Suzu, Shinya, Eto, Masatoshi, Takeya, Motohiro

“…Most malignant tumors evidence infiltration of many macrophages. In this study, we investigated an anti‐inflammatory macrophage phenotype (M2) in clear cell…”
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Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury by Honda, Masaki, Kadohisa, Masashi, Yoshii, Daiki, Komohara, Yoshihiro, Hibi, Taizo

“…Recruitment of bone marrow derived monocytes via bloodstream and their subsequent conversion to CX3CR1 + macrophages in response to intestinal injury is…”
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Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes by Komohara, Yoshihiro, Kurotaki, Daisuke, Tsukamoto, Hirotake, Miyasato, Yuko, Yano, Hiromu, Pan, Cheng, Yamamoto, Yutaka, Fujiwara, Yukio

“…Tumor‐associated macrophages (TAMs) are the most prominent immune cells in the breast cancer microenvironment, and the protumor functions of TAMs are thought…”
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Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription‐3 and nuclear factor‐kappa B in tumor cells and tumor‐associated macrophages by Fujiwara, Yukio, Komohara, Yoshihiro, Ikeda, Tsuyoshi, Takeya, Motohiro

“…Tumor‐associated macrophages (TAM) of M2 phenotype promote tumor proliferation and are associated with a poor prognosis in patients with glioblastoma. We…”
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Prognostic impacts of the combined positive score and the tumor proportion score for programmed death ligand-1 expression by double immunohistochemical staining in patients with advanced gastric cancer by Yamashita, Kohei, Iwatsuki, Masaaki, Harada, Kazuto, Eto, Kojiro, Hiyoshi, Yukiharu, Ishimoto, Takatsugu, Nagai, Yohei, Iwagami, Shiro, Miyamoto, Yuji, Yoshida, Naoya, Komohara, Yoshihiro, Ajani, Jaffer A., Baba, Hideo

“…Background The tumor proportion score (TPS) and combined positive score (CPS) have been developed to assess programmed death ligand 1 (PD-L1) expression in…”
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Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma by Liu, Yang, Baba, Yoshifumi, Ishimoto, Takatsugu, Tsutsuki, Hiroyasu, Zhang, Tianli, Nomoto, Daichi, Okadome, Kazuo, Yamamura, Kensuke, Harada, Kazuto, Eto, Kojiro, Hiyoshi, Yukiharu, Iwatsuki, Masaaki, Nagai, Yohei, Iwagami, Shiro, Miyamoto, Yuji, Yoshida, Naoya, Komohara, Yoshihiro, Ohmuraya, Masaki, Wang, Xiaoming, Ajani, Jaffer A., Sawa, Tomohiro, Baba, Hideo

“…Background Fusobacterium nucleatum ( F. nucleatum ) is a gut microbe implicated in gastrointestinal tumorigenesis. Predicting the chemotherapeutic response is…”
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The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets by Tsukamoto, Hirotake, Komohara, Yoshihiro, Oshiumi, Hiroyuki

“…Malignant tumors comprise various types of normal cells and tumor cells, and are infiltrated by large numbers of immune cells, including macrophages. The…”
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CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma by Shiraishi, Daisuke, Fujiwara, Yukio, Horlad, Hasita, Saito, Yoichi, Iriki, Toyohisa, Tsuboki, Junko, Cheng, Pan, Nakagata, Naomi, Mizuta, Hiroshi, Bekki, Hirofumi, Nakashima, Yasuharu, Oda, Yoshinao, Takeya, Motohiro, Komohara, Yoshihiro

“…Recent findings have shown the significance of CD163-positive macrophages in tumor progression, yet there have been few studies on the function of CD163 in…”
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An IL‐27/Stat3 axis induces expression of programmed cell death 1 ligands (PD‐L1/2) on infiltrating macrophages in lymphoma by Horlad, Hasita, Ma, Chaoya, Yano, Hiromu, Pan, Cheng, Ohnishi, Koji, Fujiwara, Yukio, Endo, Shinya, Kikukawa, Yoshitaka, Okuno, Yutaka, Matsuoka, Masao, Takeya, Motohiro, Komohara, Yoshihiro

“…Immune escape and tolerance in the tumor microenvironment are closely involved in tumor progression, and are caused by T‐cell exhaustion and mediated by the…”
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Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties by Terashima, Yuya, Toda, Etsuko, Itakura, Meiji, Otsuji, Mikiya, Yoshinaga, Sosuke, Okumura, Kazuhiro, Shand, Francis H. W., Komohara, Yoshihiro, Takeda, Mitsuhiro, Kokubo, Kana, Chen, Ming-Chen, Yokoi, Sana, Rokutan, Hirofumi, Kofuku, Yutaka, Ohnishi, Koji, Ohira, Miki, Iizasa, Toshihiko, Nakano, Hirofumi, Okabe, Takayoshi, Kojima, Hirotatsu, Shimizu, Akira, Kanegasaki, Shiro, Zhang, Ming-Rong, Shimada, Ichio, Nagase, Hiroki, Terasawa, Hiroaki, Matsushima, Kouji

“…Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a…”
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The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis by Sato, Michio, Kadomatsu, Tsuyoshi, Miyata, Keishi, Warren, Junco S., Tian, Zhe, Zhu, Shunshun, Horiguchi, Haruki, Makaju, Aman, Bakhtina, Anna, Morinaga, Jun, Sugizaki, Taichi, Hirashima, Kaname, Yoshinobu, Kumiko, Imasaka, Mai, Araki, Masatake, Komohara, Yoshihiro, Wakayama, Tomohiko, Nakagawa, Shinichi, Franklin, Sarah, Node, Koichi, Araki, Kimi, Oike, Yuichi

“…In the past decade, many long noncoding RNAs (lncRNAs) have been identified and their in vitro functions defined, although in some cases their functions in…”
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Relationship between Fusobacterium nucleatum and antitumor immunity in colorectal cancer liver metastasis by Sakamoto, Yuki, Mima, Kosuke, Ishimoto, Takatsugu, Ogata, Yoko, Imai, Katsunori, Miyamoto, Yuji, Akiyama, Takahiko, Daitoku, Nobuya, Hiyoshi, Yukiharu, Iwatsuki, Masaaki, Baba, Yoshifumi, Iwagami, Shiro, Yamashita, Yo‐ichi, Yoshida, Naoya, Komohara, Yoshihiro, Ogino, Shuji, Baba, Hideo

“…Fusobacterium nucleatum has been detected in 8%‐13% of human colorectal cancer, and shown to inhibit immune responses against primary colorectal tumors in…”
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Histiocytic neoplasms: a brief review and differential diagnosis by Yamada, Rin, Komohara, Yoshihiro

“…Histiocytic neoplasms (HNs) include juvenile xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, ALK-positive histiocytosis, and histiocytic…”
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Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance by Uchihara, Tomoyuki, Miyake, Keisuke, Yonemura, Atsuko, Komohara, Yoshihiro, Itoyama, Rumi, Koiwa, Mayu, Yasuda, Tadahito, Arima, Kota, Harada, Kazuto, Eto, Kojiro, Hayashi, Hiromitsu, Iwatsuki, Masaaki, Iwagami, Shiro, Baba, Yoshifumi, Yoshida, Naoya, Yashiro, Masakazu, Masuda, Mari, Ajani, Jaffer A, Tan, Patrick, Baba, Hideo, Ishimoto, Takatsugu

“…Extracellular vesicles (EV) from cancer-associated fibroblasts (CAF) are composed of diverse payloads. Although CAFs impact the aggressive characteristics of…”
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Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors by Kawamura, Kyoko, Komohara, Yoshihiro, Takaishi, Kiyomi, Katabuchi, Hidetaka, Takeya, Motohiro

“…Tumor‐associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and…”
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