Search Results - "KOMODA, Hiroshi"

EGCG, a green tea catechin, attenuates the progression of heart failure induced by the heart/muscle-specific deletion of MnSOD in mice by Oyama, Jun-ichi, MD, PhD, Shiraki, Aya, MD, PhD, Nishikido, Toshiyuki, MD, Maeda, Toyoki, MD, PhD, Komoda, Hiroshi, PhD, Shimizu, Takahiko, PhD, Makino, Naoki, MD, PhD, Node, Koichi, MD, PhD, FJCC

“…Abstract Background Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme affected in heart/muscle-specific MnSOD-deficient mice…”
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Generation of a lung squamous cell carcinoma three-dimensional culture model with keratinizing structures by Kawai, Shigeto, Nakano, Kiyotaka, Tamai, Keiichi, Fujii, Etsuko, Yamada, Mimori, Komoda, Hiroshi, Sakumoto, Hirofumi, Natori, Osamu, Suzuki, Masami

“…Tumor nests in lung squamous cell carcinoma (LUSC) have a hierarchical structure resembling squamous epithelium. The nests consist of basal-like cells on the…”
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Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel by Komoda, Hiroshi, Shiraki, Aya, Oyama, Jun-ichi, Nishikido, Toshiyuki, Node, Koichi

“…Aim: Recently, calcium channel blockers (CCBs) have been reported to reduce atherosclerosis with anti-inflammatory or antiatherosclerotic effects in vivo. It…”
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Deletion of Apoptosis Inhibitor of Macrophage (AIM)/CD5L Attenuates the Inflammatory Response and Infarct Size in Acute Myocardial Infarction by Nishikido, Toshiyuki, Oyama, Jun‐ichi, Shiraki, Aya, Komoda, Hiroshi, Node, Koichi

“…Background An excessive inflammatory response after myocardial infarction (MI) increases myocardial injury. The toll‐like receptor (TLR)‐4 is activated by the…”
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The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea by Oyama, Jun-ichi, MD, PhD, Nagatomo, Daisuke, MD, Yoshioka, Goro, MD, Yamasaki, Ayumu, MD, Kodama, Kazuhisa, MD, Sato, Michio, MD, Komoda, Hiroshi, PhD, Nishikido, Toshiyuki, MD, Shiraki, Aya, MD, PhD, Node, Koichi, MD, PhD, FJCC

“…Abstract Background Obstructive sleep apnea (OSA) is characterized by repetitive intermittent hypoxia and reoxygenation during sleep with elevated oxidative…”
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Tropical fruit camu-camu ( Myrciaria dubia ) has anti-oxidative and anti-inflammatory properties by Inoue, Teruo, MD, Komoda, Hiroshi, MS, Uchida, Toshihiko, MD, Node, Koichi, MD

“…Summary Background Oxidative stress as well as inflammation plays a pivotal role in the pathogenesis of atherosclerosis. Although, various anti-oxidative…”
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Hypercholesterolemia Causes Circadian Dysfunction: A Potential Risk Factor for Cardiovascular Disease by Akashi, Makoto, Matsumura, Ritsuko, Matsuo, Takahiro, Kubo, Yuki, Komoda, Hiroshi, Node, Koichi

“…Hypercholesterolemia is a well-known risk factor for a wide range of diseases in developed countries. Here, we report that mice lacking functional LDLR (low…”
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High Molecular Weight Adiponectin as a Predictor of Long-Term Clinical Outcome in Patients With Coronary Artery Disease by Inoue, Teruo, MD, Kotooka, Norihiko, MD, Morooka, Toshifumi, MD, Komoda, Hiroshi, MS, Uchida, Toshihiko, MD, Aso, Yoshimasa, MD, Inukai, Toshihiko, MD, Okuno, Takehiko, BSc, Node, Koichi, MD

“…Adiponectin is an adipocyte-specific secretory protein that is highly and specifically expressed in adipose tissue, and low plasma levels of adiponectin are…”
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Pentraxin-3 regulates the inflammatory activity of macrophages by Shiraki, Aya, Kotooka, Norihiko, Komoda, Hiroshi, Hirase, Tetsuaki, Oyama, Jun-Ichi, Node, Koichi

“…Pentraxin-3 (PTX3) reportedly has protective roles in atherosclerosis and myocardial infarction, and is a useful biomarker of vascular inflammation. However,…”
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Acute effects of statin on reduction of angiopoietin-like 2 and glyceraldehyde-derived advanced glycation end-products levels in patients with acute myocardial infarction: a message from SAMIT (Statin for Acute Myocardial Infarction Trial) by Shimomura, Mitsuhiro, Oyama, Jun-ichi, Takeuchi, Masayoshi, Shibata, Yoshisato, Yamamoto, Yusuke, Kawasaki, Tomohiro, Komoda, Hiroshi, Kodama, Kazuhisa, Sakuma, Masashi, Toyoda, Shigeru, Inoue, Yohei, Mine, Daigo, Natsuaki, Masahiro, Komatsu, Aiko, Hikichi, Yutaka, Yamagishi, Sho-ichi, Inoue, Teruo, Node, Koichi

“…Experimental ischemia–reperfusion models have shown that 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, have cardioprotective…”
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Hepatitis A outbreak associated with a revolving sushi bar in Chiba, Japan: Application of molecular epidemiology by Tominaga, Atsuko, Kanda, Tatsuo, Akiike, Taro, Komoda, Hiroshi, Ito, Kenji, Abe, Asami, Aruga, Akiko, Kaneda, Satoru, Saito, Masaaki, Kiyohara, Tomoko, Wakita, Takaji, Ishii, Koji, Yokosuka, Osamu, Sugiura, Nobuyuki

“…Aim:  The number of hepatitis A cases in Japan as well as in other developed countries has been progressively decreasing during the last several years. There…”
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Properties of hepatocyte-like cell clusters from human adipose tissue-derived mesenchymal stem cells by Okura, Hanayuki, Komoda, Hiroshi, Saga, Ayami, Kakuta-Yamamoto, Aya, Hamada, Yoko, Fumimoto, Yuichi, Lee, Chun Man, Ichinose, Akihiro, Sawa, Yoshiki, Matsuyama, Akifumi

“…There are only a few reports that describe the hepatocytic differentiation potential of human adipose tissue-derived mesenchymal stem cells (hADMSCs) and no…”
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Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters by Okura, Hanayuki, Komoda, Hiroshi, Fumimoto, Yuichi, Lee, Chun-Man, Nishida, Toshirou, Sawa, Yoshiki, Matsuyama, Akifumi

“…Type 1 diabetes mellitus is caused by autoimmune destruction of insulin-producing beta cells. The major obstacle to transplantation of insulin-producing cells…”
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HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits by Saga, Ayami, Okura, Hanayuki, Soeda, Mayumi, Tani, Junko, Fumimoto, Yuichi, Komoda, Hiroshi, Moriyama, Mariko, Moriyama, Hiroyuki, Yamashita, Shizuya, Ichinose, Akihiro, Daimon, Takashi, Hayakawa, Takao, Matsuyama, Akifumi

“…► Pravastatin reduced serum total cholesterol in hADMPC-transplanted WHHL rabbits. ► Pravastatin increased the 24 h-LDL-clearance in the hADMPC-transplanted…”
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A study of the xenoantigenicity of adult pig islets cells by Komoda, Hiroshi, Miyagawa, Shuji, Kubo, Tomoko, Kitano, Etsuko, Kitamura, Hajime, Omori, Takeshi, Ito, Toshinori, Matsuda, Hikaru, Shirakura, Ryota

“…:  Background:  The pig pancreas is considered to be the most suitable source of islets for xenotransplantation into patients with type I diabetes. The purpose…”
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A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirus-mediated DAF (CD55) expression by Omori, Takeshi, Nishida, Toshirou, Komoda, Hiroshi, Fumimoto, Yuichi, Ito, Toshinori, Sawa, Yoshiki, Gao, Congxiao, Nakatsu, Shino, Shirakura, Ryota, Miyagawa, Shuji

“…:  Background:  The pig pancreas is considered to be the most suitable source of islets for xenotransplantation in patients with type I diabetes. The objective…”
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Cationized gelatin-HVJ envelope with sodium borocaptate improved the BNCT efficacy for liver tumors in vivo by Fujii, Hitoshi, Matsuyama, Akifumi, Komoda, Hiroshi, Sasai, Masao, Suzuki, Minoru, Asano, Tomoyuki, Doki, Yuichiro, Kirihata, Mitsunori, Ono, Koji, Tabata, Yasuhiko, Kaneda, Yasufumi, Sawa, Yoshiki, Lee, Chun Man

“…Boron neutron capture therapy (BNCT) is a cell-selective radiation therapy that uses the alpha particles and lithium nuclei produced by the boron neutron…”
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Development of β-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat by Shimada, Kazunori, M.D, Ito, Toshinori, M.D., Ph.D, Tanemura, Masahiro, M.D., Ph.D, Komoda, Hiroshi, M.D., Ph.D, Fumimoto, Yuichi, M.D, Kawamoto, Koichi, M.D., Ph.D, Nishida, Toshirou, M.D., Ph.D, Kaneto, Hideaki, M.D., Ph.D, Sawa, Yoshiki, M.D., Ph.D

“…Background We previously demonstrated the development of β-cells in the native pancreas after syngeneic pancreas transplantation (PTx) in a model of type 2…”
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Stage-dependent effect of pancreatic transplantation on diabetic ocular complications in the spontaneously diabetic torii rat by MIAO, Gang, ITO, Toshinori, UCHIKOSHI, Fumihiro, KAMEI, Motohiro, AKAMARU, Yusuke, KIYOMOTO, Tetsuma, KOMODA, Hiroshi, NOZAWA, Masumi, MATSUDA, Hikaru

“…In terms of the temporal relationship between pancreas transplantation (PTx) and reversal of diabetic ocular complications, it has been difficult but important…”
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The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells by Shiraki, Aya, Oyama, Jun-ichi, Komoda, Hiroshi, Asaka, Machiko, Komatsu, Aiko, Sakuma, Masashi, Kodama, Kazuhisa, Sakamoto, Yoshiko, Kotooka, Norihiko, Hirase, Tetsuaki, Node, Koichi

“…Highlights ► Liraglutide can normalize TNF-α-induced pro-oxidant production in HUVEC probably through reduced expression of NADPH oxidase subunit gp91phox and…”
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