Search Results - "KOMIYA, Izumi"

Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue by Yanagida, Chie, Ito, Kousei, Komiya, Izumi, Horie, Toshiharu

“…Fosfomycin is clinically recognized to reduce the aminoglycoside antibiotics-induced nephrotoxicity. However, little has been clarified why fosfomycin protects…”
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A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug by Okudaira, N, Tatebayashi, T, Speirs, G C, Komiya, I, Sugiyama, Y

“…The intestinal absorption of a prodrug is affected by a number of factors, such as its membrane permeability, stability in the gut lumen, and conversion to the…”
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Studies on the Cytochrome P450 (CYP)-Mediated Metabolic Properties of Miocamycin: Evaluation of the Possibility of a Metabolic Intermediate Complex Formation with CYP, and Identification of the Human CYP Isoforms by KASAHARA, M, SUZUKI, H, KOMIYA, I

“…Some macrolide antibiotics cause clinical drug interactions, resulting in altered metabolism of concomitantly administered drugs, via the formation of a…”
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Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid by OKUDAIRA, Noriko, FUJIGAKI, Masao, NAKAYOSHI, Takemi, KOMIYA, Izumi, SUGIYAMA, Yuichi

“…Pivalic acid (PVA) forms conjugates with endogenous carnitine and enhances its excretion. The purpose of this study is to determine whether tissue carnitine…”
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Physiological models are good tools to predict rat bioavailability of EF5154 prodrugs from in vitro intestinal parameters by Nomoto, Masahiro, Tatebayashi, Tomoko, Morita, Jun, Suzuki, Hisashi, Aizawa, Kazumasa, Kurosawa, Tohru, Komiya, Izumi

“…There are only a few reports on the methods that predict in vivo bioavailability from in vitro intestinal parameters. In the present study, we constructed…”
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Toxicokinetic approach for evaluating respiratory depression effect of aminoglycoside antibiotics: species differences in drug susceptibility by Komiya, I, Mitomi, N, Kuribayashi, T, Takata, H

“…The respiratory depression effect of aminoglycoside antibiotics was studied by a toxicokinetic approach, and species differences in drug susceptibility were…”
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Urine flow-dependence and interspecies variation of the renal reabsorption of sulfanilamide by Komiya, I

“…A physiologically based model for drug reabsorption in renal tubules was applied to sulfanilamide reabsorption kinetics in rats, rabbits and dogs. The…”
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Synthesis and biological activity of (cyclopentenopyridinium) thiomethylcephalosporins by Katano, K, Ogino, H, Iwamatsu, K, Nakabayashi, S, Yoshida, T, Komiya, I, Tsuruoka, T, Inouye, S, Kondo, S

“…Substituted (cyclopentenopyridinium)thiomethyl groups were introduced as C-3 substituents of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-oxyimino]acetami…”
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Relationship between students' interests in science and attitudes toward nuclear power generation by Komiya, Izumi, Torii, Hiroyuki, Fujii, Yasuhiko, Hayashizaki, Noriyosu

“…In order to study the following two points, we conducted an attitude survey among senior high school students. Study 1 The differences in attitudes between…”
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Pharmacological profiles of ME3230, a novel orally active GPIIb/IIIa antagonist by Kato, Emiko, Ohuchi, Shokichi, Iida, Hiroyuki, Kataha, Kazuyoshi, Nomura, Misako, Sugano, Toshie, Komiya, Izumi

“…ME3230 is a new orally active GPIIb/IIIa antagonist that is a prodrug of EF5154. In this study, we examined antiplatelet and antithrombotic activity of these…”
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ASSAY METHOD OF ME 1207, A NOVEL ORAL CEPHEM ANTIBIOTIC, IN BIOLOGICAL BODY FLUIDS: II. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY METHOD by Matsumoto, Takashi, Komiya, Izumi

“…ME 1207, a novel oral cephem antibiotic, is a prodrug of ME1206 which has a potent activity against a broad spectrum of bacteria. A high-performance liquid…”
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FOSFOMYCIN (FOM) DISTRIBUTION INTO SKIN, ADIPOSE TISSUE, MUSCLE, AND BONE IN HUMANS: PROPHYLACTIC USE OF FOM IN PREVENTION OF POSTOPERATIVE INFECTION by KURATA, KAZUO, KOMIYA, IZUMI

“…Fosfomycin was investigated on its distribution after a continuous intravenous drip infusion of 4g for 1.0 hr. in humans, and its serum levels, skin, adipose…”
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Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine by Okudaira, N, Komiya, I, Sugiyama, Y

“…ME3229 is an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist ME3277. In our previous study, it was shown that only a small part of the drug…”
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ANTIBIOTIC CONCENTRATIONS IN NORMAL CEREBROSPINAL FLUID: FOM, CMNX, ABPC, DKB by KURATA, KAZUO, KOMIYA, IZUMI, SINKAI, SACHIHIKO

“…Concentrations of several antibiotics, FOM, CMNX, ABPC and DKB, in normal cerebrospinal fluid (CSF) were determined after a continuous intravenous drip…”
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Renal excretion mechanism of ME1206, an active form of a novel oral cephalosporin antibiotic ME1207, in rats, rabbits and dogs by KURIBAYASHI, Takashi, OKAMOTO, Jun-ichi, KOMIYA, Izumi

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TOXICOLOGICAL STUDIES ON RIBOSTAMYCIN: Acute toxicity and pharmacokinetics by KOEDA, TAKEMI, SUNO, KIMIKO, HORISAKA, KAZUYOSHI, KOMIYA, IZUMI

“…The toxicity of ribostamycin (RSM) which belongs to aminoglycosidic antibiotics was studiedusing rats, and the following results were obtained. The LD50 value…”
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Pharmacokinetics of dibekacin after intramuscular administration in man by Umemura, K, Komiya, I, Nakadori, S, Chow, S Y

“…Pharmacokinetic behavior of dibekacin after intramuscular administration was studied in nine healthy volunteers by cross over administrations of three dosage…”
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PHASE I CLINICAL STUDIES ON A NOVEL ORAL CEPHEM ANTIBIOTIC, ME 1207 by Shimada, Kaoru, Matsumoto, Takashi, Komiya, Izumi, Shinkai, Sachihiko

“…ME 1207, a novel oral cephem antibiotic, is a prodrug of ME1206 which has a potent activity againsta broad spectrum of bacteria.Our preclinical animal studies…”
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PHARMACOKINETICS OF ME 1207, A NOVEL ORAL CEPHEM ANTIBIOTIC, IN EXPERIMENTAL ANIMALS by Matsumoto, Takashi, Okamoto, Junichi, Saito, Kouichi, Aizawa, Kazumasa, Komiya, Izumi

“…The pharmacokinetics of ME 1207, a new oral cephem antibiotic, was studied in mice, rats and dogs. 1. ME 1207 was mainly absorbed from the upper part of the…”
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ASSAY METHOD OF HBK IN BIOLOGICAL BODY FLUIDS: II. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY METHOD by KOMIYA, IZUMI, MITOMI, NAYU, NISHIO, MOTOHIRO

“…A procedure for the high-performance liquid chromatographic (HPLC) determination of HBK in serum (or plasma) urine, and bile is described using post-column…”
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