Search Results - "KOMAZAWA, Nobuyasu"

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis by Chan, Keith Syson, Sano, Shigetoshi, Kiguchi, Kaoru, Anders, Joanne, Komazawa, Nobuyasu, Takeda, Junji, DiGiovanni, John

“…Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a wide spectrum of human malignancies. Here, we have…”
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Involvement of connective tissue–type mast cells in Th1 immune responses via Stat4 expression by Kataoka, Tatsuki R., Komazawa, Nobuyasu, Morii, Eiichi, Oboki, Keisuke, Nakano, Toru

“…Mast cells are the sentinels of immune systems and, like other immuno-competent cells, they are produced by hematopoietic stem cells. We analyzed the…”
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Tumorigenesis facilitated by Pten deficiency in the skin: Evidence of p53‐Pten complex formation on the initiation phase by Komazawa, Nobuyasu, Suzuki, Akira, Sano, Shigetoshi, Horie, Kyoji, Matsuura, Nariaki, Mak, Tak Wah, Nakano, Toru, Takeda, Junji, Kondoh, Gen

“…Pten, a tumor suppressor gene, is mutated in various human cancers and in hereditary cancer syndromes, such as Cowden disease. We have previously developed a…”
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Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation by SUZUKI, Akira, ITAMI, Satoshi, TAK WAH MAK, NAKANO, Toru, OHISHI, Minako, HAMADA, Koichi, INOUE, Tae, KOMAZAWA, Nobuyasu, SENOO, Haruki, SASAKI, Takehiko, TAKEDA, Junji, MANABE, Motomu

“…PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate a keratinocyte-specific null mutation of Pten in mice…”
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Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization by Kondoh, Gen, Takeda, Junji, Tojo, Hiromasa, Nakatani, Yuka, Komazawa, Nobuyasu, Murata, Chie, Yamagata, Kazuo, Maeda, Yusuke, Kinoshita, Taroh, Okabe, Masaru, Taguchi, Ryo

“…The angiotensin-converting enzyme (ACE) is a key regulator of blood pressure. It is known to cleave small peptides, such as angiotensin I and bradykinin and…”
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Reduced expression of IL-12 receptor β2 and IL-18 receptor α genes in natural killer cells and macrophages derived from B6-mi/mi mice by Kataoka, Tatsuki R, Komazawa, Nobuyasu, Oboki, Keisuke, Morii, Eiichi, Nakano, Toru

“…The mi transcriptional factor (MITF) is a basic helix–loop–helix leucine zipper-type transcriptional factor. The mi mutant allele encodes an abnormal MITF, in…”
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Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice by Shimomura, Iichiro, Komazawa, Nobuyasu, Matsuda, Morihiro, Kondoh, Gen, Mizunoya, Wataru, Iwaki, Masanori, Takagi, Toshiyuki, Sumikawa, Yasuyuki, Inoue, Kazuo, Suzuki, Akira, Mak, Tak Wah, Nakano, Toru, Fushiki, Tohru, Takeda, Junji

“…Pten is an important phosphatase, suppressing the phosphatidylinositol-3 kinase/Akt pathway. Here, we generated adipose-specific Pten-deficient (AdipoPten-KO)…”
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Reduced expression of IL-12 receptor [beta]2 and IL-18 receptor [alpha] genes in natural killer cells and macrophages derived from B6-mi/mi mice by Kataoka, Tatsuki R, Komazawa, Nobuyasu, Oboki, Keisuke, Morii, Eiichi, Nakano, Toru

“…The mi transcriptional factor (MITF) is a basic helix-loop-helix leucine zipper-type transcriptional factor. The mi mutant allele encodes an abnormal MITF, in…”
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Reduced expression of IL-12 receptor beta2 and IL-18 receptor alpha genes in natural killer cells and macrophages derived from B6-mi/mi mice by Kataoka, Tatsuki R, Komazawa, Nobuyasu, Oboki, Keisuke, Morii, Eiichi, Nakano, Toru

“…The mi transcriptional factor (MITF) is a basic helix-loop-helix leucine zipper-type transcriptional factor. The mi mutant allele encodes an abnormal MITF, in…”
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Ahnak/Desmoyokin Is Dispensable for Proliferation, Differentiation, and Maintenance of Integrity in Mouse Epidermis by Kouno, Michiyoshi, Kondoh, Gen, Horie, Kyoji, Komazawa, Nobuyasu, Ishii, Norito, Takahashi, Yoshie, Takeda, Junji, Hashimoto, Takashi

“…Desmoyokin was first isolated from bovine muzzle epidermis and thought to be an epidermal desmosome-related protein. We previously demonstrated that the…”
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