Search Results - "KOMATSU, NOBUKAZU"

CD4/CD8 ratio is a prognostic factor in IgG nonresponders among peptide vaccine‐treated ovarian cancer patients by Waki, Kayoko, Kawano, Kouichiro, Tsuda, Naotake, Komatsu, Nobukazu, Yamada, Akira

“…The identification of useful biomarkers is an urgent issue in cancer treatment, particularly for immunotherapy, as only some patients experience benefits from…”
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A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma by Narita, Yoshitaka, Arakawa, Yoshiki, Yamasaki, Fumiyuki, Nishikawa, Ryo, Aoki, Tomokazu, Kanamori, Masayuki, Nagane, Motoo, Kumabe, Toshihiro, Hirose, Yuichi, Ichikawa, Tomotsugu, Kobayashi, Hiroyuki, Fujimaki, Takamitsu, Goto, Hisaharu, Takeshima, Hideo, Ueba, Tetsuya, Abe, Hiroshi, Tamiya, Takashi, Sonoda, Yukihiko, Natsume, Atsushi, Kakuma, Tatsuyuki, Sugita, Yasuo, Komatsu, Nobukazu, Yamada, Akira, Sasada, Tetsuro, Matsueda, Satoko, Shichijo, Shigeki, Itoh, Kyogo, Terasaki, Mizuhiko

“…Abstract Background We conducted a phase III trial of personalized peptide vaccination (PPV) for human leukocyte antigen (HLA)-A24+ recurrent glioblastoma to…”
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STAT1 Mutations in Chronic Mucocutaneous Candidiasis Diagnosed in an Adult by Andou, Miya, Tominaga, Masaki, Nishikomori, Ryuta, Gotoh, Kenji, Komatsu, Nobukazu, Matsuoka, Masanobu, Kawayama, Tomotaka, Hoshino, Tomoaki

“…A 30-year-old man presented with oral candidiasis and a history of lung abscess. He experienced recurring oral and skin candidiasis in childhood but spent long…”
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PD‐1 expression on peripheral blood T‐cell subsets correlates with prognosis in non‐small cell lung cancer by Waki, Kayoko, Yamada, Teppei, Yoshiyama, Koichi, Terazaki, Yasuhiro, Sakamoto, Shinjiro, Matsueda, Satoko, Komatsu, Nobukazu, Sugawara, Shunichi, Takamori, Shinzo, Itoh, Kyogo, Yamada, Akira

“…PD‐1 expression in peripheral blood T‐cells has been reported in several kinds of cancers, including lung cancer. However, the relationship between PD‐1…”
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Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients by Iwasa, Satoru, Yamada, Yasuhide, Heike, Yuji, Shoji, Hirokazu, Honma, Yoshitaka, Komatsu, Nobukazu, Matsueda, Satoko, Yamada, Akira, Morita, Michi, Yamaguchi, Rin, Tanaka, Natsuki, Kawahara, Akihiko, Kage, Masayoshi, Shichijo, Shigeki, Sasada, Tetsuro, Itoh, Kyogo

“…A phase I study of a new cancer vaccine (KRM‐10), consisting of a mixture of 10 different short peptides, was conducted for patients with advanced…”
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Identification of biomarkers for personalized peptide vaccination in 2,588 cancer patients by Suekane, Shigetaka, Yutani, Shigeru, Yamada, Akira, Sasada, Tetsuro, Matsueda, Satoko, Takamori, Shinzo, Toh, Uhi, Kawano, Kouichiro, Yoshiyama, Koichi, Sakamoto, Shinjiro, Sugawara, Shunichi, Komatsu, Nobukazu, Yamada, Teppei, Naito, Masayasu, Terasaki, Mizuhiko, Mine, Takashi, Itoh, Kyogo, Shichijo, Shigeki, Noguchi, Masanori

“…Peptide‑based cancer vaccines have failed to provide sufficient clinical benefits in order to be approved in clinical trials since the 1990s. To understand the…”
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A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients by YUTANI, SHIGERU, KOMATSU, NOBUKAZU, YOSHITOMI, MUNEHIRO, MATSUEDA, SATOKO, YONEMOTO, KOJI, MINE, TAKASHI, NOGUCHI, MASANORI, ISHIHARA, YUKI, YAMADA, AKIRA, ITOH, KYOGO, SASADA, TETSURO

“…Pancreatic cancer is one of the most aggressive cancers with a median survival time (MST) of <6 months in chemotherapy-resistant patients. Therefore, the…”
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Gene expression profiles in peripheral blood as a biomarker in cancer patients receiving peptide vaccination by Komatsu, Nobukazu, Matsueda, Satoko, Tashiro, Kousuke, Ioji, Tetsuya, Shichijo, Shigeki, Noguchi, Masanori, Yamada, Akira, Doi, Atsushi, Suekane, Shigetaka, Moriya, Fukuko, Matsuoka, Kei, Kuhara, Satoru, Itoh, Kyogo, Sasada, Tetsuro

“…BACKGROUND: Because only a subset of patients show clinical responses to peptide‐based cancer vaccination, it is critical to identify biomarkers for selecting…”
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Phase II study of personalized peptide vaccination for previously treated advanced colorectal cancer by Kibe, Shiro, Yutani, Shigeru, Motoyama, Satoru, Nomura, Takanobu, Tanaka, Natsuki, Kawahara, Akihiko, Yamaguchi, Tomohiko, Matsueda, Satoko, Komatsu, Nobukazu, Miura, Masatomo, Hinai, Yudai, Hattori, Satoshi, Yamada, Akira, Kage, Masayoshi, Itoh, Kyogo, Akagi, Yoshito, Sasada, Tetsuro

“…The prognosis of advanced colorectal cancer (aCRC) remains poor, and development of new therapeutic approaches, including immunotherapy, is needed urgently…”
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Immunological evaluation of personalized peptide vaccination in refractory small cell lung cancer by Terazaki, Yasuhiro, Yoshiyama, Koichi, Matsueda, Satoko, Watanabe, Noriko, Kawahara, Akihiko, Naito, Yoshiki, Suekane, Shigetaka, Komatsu, Nobukazu, Ioji, Tetsuya, Yamada, Akira, Mine, Takashi, Terasaki, Mizuhiko, Itoh, Kyogo, Takamori, Shinzo, Sasada, Tetsuro

“…Since the prognosis of small cell lung cancer (SCLC) remains poor, development of new therapeutic approaches, including immunotherapies, would be desirable. In…”
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Phase I clinical study of a peptide vaccination for hepatitis C virus‐infected patients with different human leukocyte antigen‐class I‐A alleles by Yutani, Shigeru, Komatsu, Nobukazu, Shichijo, Shigeki, Yoshida, Kazumi, Takedatsu, Hiroko, Itou, Minoru, Kuromatu, Ryoko, Ide, Tatsuya, Tanaka, Masatoshi, Sata, Michio, Yamada, Akira, Itoh, Kyogo

“…Hepatitis C virus (HCV) infection has a high risk of liver cirrhosis and hepatocellular carcinoma at later stages. We recently identified a peptide derived…”
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Immunologic Evaluation of Personalized Peptide Vaccination for Patients with Advanced Malignant Glioma by YAJIMA, Naoki, YAMANAKA, Ryuya, YAMADA, Akira, SHIGEMORI, Minoru, ITOH, Kyogo, TANAKA, Ryuichi, MINE, Takashi, TSUCHIYA, Naoto, HOMMA, Jumpei, SANO, Masakazu, KURAMOTO, Terukazu, OBATA, Yayoi, KOMATSU, Nobukazu, ARIMA, Yoshimi

“…Purpose: The primary goal of this phase I study was to assess the safety and immunologic responses of personalized peptide vaccination for patients with…”
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Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients by Araki, Hiromitsu, Pang, Xiaoliang, Komatsu, Nobukazu, Soejima, Mikiko, Miyata, Nawoe, Takaki, Mari, Muta, Shigeru, Sasada, Tetsuro, Noguchi, Masanori, Koda, Yoshiro, Itoh, Kyogo, Kuhara, Satoru, Tashiro, Kosuke

“…Personalized peptide vaccination (PPV) is an attractive approach to cancer immunotherapy with strong immune-boosting effects conferring significant clinical…”
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Haptoglobin Proved a Prognostic Biomarker in Peripheral Blood of Patients with Personalized Peptide Vaccinations for Advanced Castration-Resistant Prostate Cancer by PANG, Xiaoliang, TASHIRO, Kosuke, EGUCHI, Rieko, KOMATSU, Nobukazu, SASADA, Tetsuro, ITOH, Kyogo, KUHARA, Satoru

“…Haptoglobin (Hp) is a well-known acute-phase protein that possibly has influence on tumors through the immune response. This study was conducted to evaluate…”
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Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens by YAMADA, TEPPEI, TERAZAKI, YASUHIRO, SAKAMOTO, SHINJIRO, YOSHIYAMA, KOICHI, MATSUEDA, SATOKO, KOMATSU, NOBUKAZU, WAKI, KAYOKO, YAMADA, AKIRA, KAWAHARA, AKIHIKO, KAGE, MASAYOSHI, SUGAWARA, SHUNICHI, YAMASHITA, YUICHI, SASADA, TETSURO, TAKAMORI, SHINZO, ITOH, KYOGO

“…The prognosis of non-small cell lung cancer (NSCLC) patients who failed two or more treatment regimens remains very poor. We conducted a phase II study to…”
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Evaluation of a new oil adjuvant for use in peptide‐based cancer vaccination by Iseki, Kanako, Matsunaga, Hiromi, Komatsu, Nobukazu, Suekane, Shigetaka, Noguchi, Masanori, Itoh, Kyogo, Yamada, Akira

“…Vaccine therapies are increasingly being used for the treatment of various diseases, and the antigen molecules themselves are being expanded from whole…”
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Personalized peptide vaccination for advanced biliary tract cancer: IL-6, nutritional status and pre-existing antigen-specific immunity as possible biomarkers for patient prognosis by YOSHITOMI, MUNEHIRO, YUTANI, SHIGERU, MATSUEDA, SATOKO, IOJI, TETSUYA, KOMATSU, NOBUKAZU, SHICHIJO, SHIGEKI, YAMADA, AKIRA, ITOH, KYOGO, SASADA, TETSURO, KINOSHITA, HISAFUMI

“…Considering that the prognosis of patients with advanced biliary tract cancer (BTC) remains very poor, with a median survival of less than 1 year, new…”
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Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination by Noguchi, Masanori, Mine, Takashi, Komatsu, Nobukazu, Suekane, Shigetaka, Moriya, Fukuko, Matsuoka, Kei, Yutani, Shigeru, Shichijo, Shigeki, Yamada, Akira, Toh, Uhi, Kawano, Kouichiro, Azuma, Kouichi, Uemura, Hirotsugu, Okuno, Kiyotaka, Matsumoto, Kazumasa, Yanagimoto, Hiroaki, Yamanaka, Ryuya, Oka, Masaaki, Todo, Satoru, Sasada, Tetsuro, Itoh, Kyogo

“…To investigate immunological biomarkers to predict overall survival of advanced cancer patients under treatment with personalized peptide vaccination,…”
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Immunological evaluation of personalized peptide vaccination monotherapy in patients with castration‐resistant prostate cancer by Uemura, Hirotsugu, Fujimoto, Kiyohide, Mine, Takashi, Uejima, Shigeya, De Velasco, Marco A., Hirao, Yoshihiko, Komatsu, Nobukazu, Yamada, Akira, Itoh, Kyogo

“…(Cancer Sci 2010; 101: 601–608) We previously reported that personalized peptide vaccine (PPV) therapy in combination with leutenizing hormone‐releasing…”
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Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advanced Hepatocellular Carcinoma Patients by Itoh, Kyogo, Sasada, Tetsuro, Kudo, Masatoshi, Noguchi, Masanori, Shichijo, Shigeki, Komatsu, Nobukazu, Matsueda, Satoko, Eguchi, Junichi, Ishiguro, Atsushi, Abe, Kazumichi, Ueshima, Kazuomi, Yutani, Shigeru, Yamada, Akira

“…Objective. To evaluate safety and immune responses of personalized peptide vaccination (PPV) for hepatitis C virus- (HCV-) positive advanced hepatocellular…”
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