Search Results - "KOMAR, A"

A pause for thought along the co-translational folding pathway by Komar, Anton A.

“…A unifying concept that combines the basic features governing self-organization of proteins into complex three-dimensional structures in vitro and in vivo is…”
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Cellular IRES-mediated translation: The war of ITAFs in pathophysiological states by Komar, Anton A, Hatzoglou, Maria

“…Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has received increased attention during recent years due to its emerging…”
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Molecular Peptide Grafting as a Tool to Create Novel Protein Therapeutics by Komar, Anton A

“…The study of peptides (synthetic or corresponding to discrete regions of proteins) has facilitated the understanding of protein structure-activity…”
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A Retrospective on eIF2A-and Not the Alpha Subunit of eIF2 by Komar, Anton A, Merrick, William C

“…Initiation of protein synthesis in eukaryotes is a complex process requiring more than 12 different initiation factors, comprising over 30 polypeptide chains…”
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Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations by Buhr, Florian, Jha, Sujata, Thommen, Michael, Mittelstaet, Joerg, Kutz, Felicitas, Schwalbe, Harald, Rodnina, Marina V., Komar, Anton A.

“…In all genomes, most amino acids are encoded by more than one codon. Synonymous codons can modulate protein production and folding, but the mechanism…”
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Cotranslational protein folding on the ribosome monitored in real time by Holtkamp, Wolf, Kokic, Goran, Jäger, Marcus, Mittelstaet, Joerg, Komar, Anton A, Rodnina, Marina V

“…Protein domains can fold into stable tertiary structures while they are synthesized on the ribosome. We used a high-performance, reconstituted in vitro…”
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Internal Ribosome Entry Sites in Cellular mRNAs: Mystery of Their Existence by Komar, Anton A., Hatzoglou, Maria

“…Although studies on viral gene expression were essential for the discovery of internal ribosome entry sites (IRESs), it is becoming increasingly clear that…”
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Synonymous Codon Usage—a Guide for Co-Translational Protein Folding in the Cell by Komar, A. A.

“…—In the cell, protein folding begins during protein synthesis/translation and thus is a co-translational process. Co-translational protein folding is tightly…”
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Efficient engineering of human and mouse primary cells using peptide-assisted genome editing by Zhang, Zhen, Baxter, Amy E., Ren, Diqiu, Qin, Kunhua, Chen, Zeyu, Collins, Sierra M., Huang, Hua, Komar, Chad A., Bailer, Peter F., Parker, Jared B., Blobel, Gerd A., Kohli, Rahul M., Wherry, E. John, Berger, Shelley L., Shi, Junwei

“…Simple, efficient and well-tolerated delivery of CRISPR genome editing systems into primary cells remains a major challenge. Here we describe an engineered…”
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Exploring Internal Ribosome Entry Sites as Therapeutic Targets by Komar, Anton A, Hatzoglou, Maria

“…Initiation of eukaryotic mRNA translation may proceed via several different routes, each requiring a different subset of factors and relying on different and…”
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A Unique ISR Program Determines Cellular Responses to Chronic Stress by Guan, Bo-Jhih, van Hoef, Vincent, Jobava, Raul, Elroy-Stein, Orna, Valasek, Leos S., Cargnello, Marie, Gao, Xing-Huang, Krokowski, Dawid, Merrick, William C., Kimball, Scot R., Komar, Anton A., Koromilas, Antonis E., Wynshaw-Boris, Anthony, Topisirovic, Ivan, Larsson, Ola, Hatzoglou, Maria

“…The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) stress. In acute/transient ER stress, decreased global…”
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Synonymous Codon Usage-a Guide for Co-Translational Protein Folding in the Cell by Komar, A A

“…In the cell, protein folding begins during protein synthesis/translation and thus is a co-translational process. Co-translational protein folding is tightly…”
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Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling by Skabkin, Maxim A, Skabkina, Olga V, Dhote, Vidya, Komar, Anton A, Hellen, Christopher U T, Pestova, Tatyana V

“…Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In…”
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Mouse embryo CoCoPUTs: novel murine transcriptomic-weighted usage website featuring multiple strains, tissues, and stages by Fumagalli, Sarah E, Smith, Sean, Ghazanchyan, Tigran, Meyer, Douglas, Paul, Rahul, Campbell, Collin, Santana-Quintero, Luis, Golikov, Anton, Ibla, Juan, Bar, Haim, Komar, Anton A, Hunt, Ryan C, Lin, Brian, DiCuccio, Michael, Kimchi-Sarfaty, Chava

“…Mouse (Mus musculus) models have been heavily utilized in developmental biology research to understand mammalian embryonic development, as mice share many…”
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Gene variants of coagulation related proteins that interact with SARS-CoV-2 by Holcomb, David, Alexaki, Aikaterini, Hernandez, Nancy, Hunt, Ryan, Laurie, Kyle, Kames, Jacob, Hamasaki-Katagiri, Nobuko, Komar, Anton A, DiCuccio, Michael, Kimchi-Sarfaty, Chava

“…Thrombosis is a recognized complication of Coronavirus disease of 2019 (COVID-19) and is often associated with poor prognosis. There is a well-recognized link…”
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Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex by Che, Kepeng, Pobbati, Ajaybabu V, Seavey, Caleb N, Fedorov, Yuriy, Komar, Anton A, Burtscher, Ashley, Ma, Shuang, Rubin, Brian P

“…Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction…”
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Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma by Gartner, Jared J., Parker, Stephen C. J., Prickett, Todd D., Dutton-Regester, Ken, Stitzel, Michael L., Lin, Jimmy C., Davis, Sean, Simhadri, Vijaya L., Jha, Sujata, Katagiri, Nobuko, Gotea, Valer, Teer, Jamie K., Wei, Xiaomu, Morken, Mario A., Bhanot, Umesh K., Chen, Guo, Elnitski, Laura L., Davies, Michael A., Gershenwald, Jeffrey E., Carter, Hannah, Karchin, Rachel, Robinson, William, Robinson, Steven, Rosenberg, Steven A., Collins, Francis S., Parmigiani, Giovanni, Komar, Anton A., Kimchi-Sarfaty, Chava, Hayward, Nicholas K., Margulies, Elliott H., Samuels, Yardena

“…Synonymous mutations, which do not alter the protein sequence, have been shown to affect protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet…”
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The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation by Yang, Hsin-Sheng, Jansen, Aaron P., Komar, Anton A., Zheng, Xiaojing, Merrick, William C., Costes, Sylvain, Lockett, Stephen J., Sonenberg, Nahum, Colburn, Nancy H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation by Komar, Anton A, Lesnik, Thierry, Reiss, Claude

“…To investigate the possible influence of the local rates of translation on protein folding, 16 consecutive rare (in Escherichia coli) codons in the…”
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Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2 by Zinoviev, Alexandra, Goyal, Akanksha, Jindal, Supriya, LaCava, John, Komar, Anton A, Rodnina, Marina V, Hellen, Christopher U T, Pestova, Tatyana V

“…GTP-binding protein 1 (GTPBP1) and GTPBP2 comprise a divergent group of translational GTPases with obscure functions, which are most closely related to eEF1A,…”
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