Search Results - "KOLOSSOV, Eugen"

Host-Dependent Tumorigenesis of Embryonic Stem Cell Transplantation in Experimental Stroke by Erdö, Franciska, Bührle, Christian, Blunk, James, Hoehn, Mathias, Xia, Ying, Fleischmann, Bernd, Föcking, Melanie, Küstermann, Ekkehardt, Kolossov, Eugen, Hescheler, Jürgen, Hossmann, Konstantin-A., Trapp, Thorsten

“…The therapeutical potential of transplantation of undifferentiated and predifferentiated murine embryonic stem cells for the regeneration of the injured brain…”
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Automated patch clamp on mESC-derived cardiomyocytes for cardiotoxicity prediction by Stoelzle, Sonja, Haythornthwaite, Alison, Kettenhofen, Ralf, Kolossov, Eugen, Bohlen, Heribert, George, Michael, Brüggemann, Andrea, Fertig, Niels

“…Cardiovascular side effects are critical in drug development and have frequently led to late-stage project terminations or even drug withdrawal from the…”
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Differentiation and selection of hepatocyte precursors in suspension spheroid culture of transgenic murine embryonic stem cells by Gabriel, Elke, Schievenbusch, Stephanie, Kolossov, Eugen, Hengstler, Jan G, Rotshteyn, Tamara, Bohlen, Heribert, Nierhoff, Dirk, Hescheler, Jürgen, Drobinskaya, Irina

“…Embryonic stem cell-derived hepatocyte precursor cells represent a promising model for clinical transplantations to diseased livers, as well as for…”
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Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes by Kolossov, E, Lu, Z, Drobinskaya, I, Gassanov, N, Duan, Y, Sauer, H, Manzke, O, Bloch, W, Bohlen, H, Hescheler, J, Fleischmann, B. K

“…ABSTRACT The aim of this study was to identify and functionally characterize cardiac subtypes during early stages of development. For this purpose, transgenic…”
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Activity of complex III of the mitochondrial electron transport chain is essential for early heart muscle cell differentiation by Spitkovsky, Dimitry, Sasse, Philipp, Kolossov, Eugen, Böttinger, Cornelia, Fleischmann, Bernd K., Hescheler, Jürgen, Wiesner, Rudolf J.

“…ABSTRACT During development of the heart, mitochondria proliferate within cardiomyocytes. It is unclear whether this is a response to the increasing energy…”
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Differential role of bFGF and VEGF for vasculogenesis by Kazemi, Shohreh, Wenzel, Daniela, Kolossov, Eugen, Lenka, Nibedita, Raible, Axel, Sasse, Philipp, Hescheler, Jürgen, Addicks, Klaus, Fleischmann, Bernd K, Bloch, Wihelm

“…Primary vascular plexus originate from angioblasts through a process called vasculogenesis. The precise role of basic fibroblast growth factor (bFGF) and the…”
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Dynamic monitoring of beating periodicity of stem cell‐derived cardiomyocytes as a predictive tool for preclinical safety assessment by Abassi, Yama A, Xi, Biao, Li, Nan, Ouyang, Wei, Seiler, Alexander, Watzele, Manfred, Kettenhofen, Ralf, Bohlen, Heribert, Ehlich, Andreas, Kolossov, Eugen, Wang, Xiaobo, Xu, Xiao

“…BACKGROUND AND PURPOSE Cardiac toxicity is a major concern in drug development and it is imperative that clinical candidates are thoroughly tested for adverse…”
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Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium by Kolossov, Eugen, Bostani, Toktam, Roell, Wilhelm, Breitbach, Martin, Pillekamp, Frank, Nygren, Jens M, Sasse, Philipp, Rubenchik, Olga, Fries, Jochen W U, Wenzel, Daniela, Geisen, Caroline, Xia, Ying, Lu, Zhongju, Duan, Yaqi, Kettenhofen, Ralf, Jovinge, Stefan, Bloch, Wilhelm, Bohlen, Heribert, Welz, Armin, Hescheler, Juergen, Jacobsen, Sten Eirik, Fleischmann, Bernd K

“…Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which is the most…”
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Cardiac specific differentiation of mouse embryonic stem cells by Sachinidis, Agapios, Fleischmann, Bernd K, Kolossov, Eugen, Wartenberg, Maria, Sauer, Heinrich, Hescheler, Jürgen

“…Embryonic stem (ES) cells may represent an alternative source of functionally intact cardiomyocytes for the causal treatment of cardiovascular diseases…”
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Genetic modification of cells for transplantation by Lai, Yi, Drobinskaya, Irina, Kolossov, Eugen, Chen, Chunguang, Linn, Thomas

“…Progress in gene therapy has produced promising results that translate experimental research into clinical treatment. Gene modification has been extensively…”
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In vitro pharmacology and safety testing using human iPS-derived Cor.4U cardiomyocytes by Kettenhofen, Ralf, Tressat, Kristina, Kolossov, Eugen, Hebeisen, Simon, Jaehne, Evelyn, Ehlich, Andreas, Schwengberg, Silke, Bohlen, Heribert

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Pluripotent Cell-Derived Cardiomyocytes: One Cell Type as a Predictive Tool For the Assessment of Drug Efficacy and Safety on a Variety of Cardiac Targets by Kettenhofen, Ralf F., Tressat, Kristina, Rubenchik, Olga, Stoelzle, Sonja, Yu, Ming, Sonnenhol, Eike, Meininghaus, Mark, Kalthof, Bernd, Bohlen, Heribert, Schwengberg, Silke, Kolossov, Eugen

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Scalable Selection of Hepatocyte‐ and Hepatocyte Precursor‐Like Cells from Culture of Differentiating Transgenically Modified Murine Embryonic Stem Cells by Drobinskaya, Irina, Linn, Thomas, Šarić, Tomo, Bretzel, Reinhard G., Bohlen, Heribert, Hescheler, Jürgen, Kolossov, Eugen

“…Potential therapeutic applications of embryonic stem cell (ESC)‐derived hepatocytes are limited by their relatively low output in differentiating ESC cultures,…”
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Cellular cardiomyoplasty improves survival after myocardial injury by ROELL, Wilhelm, LU, Zhong J, KOLOSSOV, Eugen, BREM, Gottfried, ADDICKS, Klaus, PFITZER, Gabriele, WELZ, Armin, HESCHELER, Juergen, FLEISCHMANN, Bernd K, BLOCH, Wilhelm, SIEDNER, Sharon, TIEMANN, Klaus, YING XIA, STOECKER, Eva, FLEISCHMANN, Michaela, BOHLEN, Heribert, STEHLE, Robert

“…Cellular cardiomyoplasty is discussed as an alternative therapeutic approach to heart failure. To date, however, the functional characteristics of the…”
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Genetic modification of cells for transplantation: Emerging trends in cell-based therapies by YI LAI, DROBINSKAYA, Irina, KOLOSSOV, Eugen, CHUNGUANG CHEN, LINN, Thomas

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Differentiation of green fluorescent protein-labeled embryonic stem cell-derived neural precursor cells into Thy-1-positive neurons and glia after transplantation into adult rat striatum by ARNHOLD, Stefan, LENARTZ, Doris, KRUTTWIG, Klaus, KLINZ, Franz-Josef, KOLOSSOV, Eugen, HESCHELER, Jürgen, STURM, Volker, ANDRESSEN, Christian, ADDICKS, Klaus

“…The aim of this investigation was to assess new information concerning the capacity of transplanted embryonic stem cell (ESC)-derived neuronal cells to migrate…”
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Cellular cardiomyoplasty in a transgenic mouse model by ROELL, Wilhelm, YUN FAN, HESCHELER, Juergen, WELZ, Armin, FLEISCHMANN, Bernd K, YING XIA, STOECKER, Eva, SASSE, Philipp, KOLOSSOV, Eugen, BLOCH, Wilhelm, METZNER, Harald, SCHMITZ, Christoph, ADDICKS, Klaus

“…Recent progress in the cardiotypic differentiation of embryonic and somatic stem cells opens novel prospects for the treatment of cardiovascular disorders. The…”
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Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium by Kolossov, Eugen, Bostani, Toktam, Roell, Wilhelm, Breitbach, Martin, Pillekamp, Frank, Nygren, Jens M., Sasse, Philipp, Rubenchik, Olga, Fries, Jochen W. U., Wenzel, Daniela, Geisen, Caroline, Xia, Ying, Lu, Zhongju, Duan, Yaqi, Kettenhofen, Ralf, Jovinge, Stefan, Bloch, Wilhelm, Bohlen, Heribert, Welz, Armin, Hescheler, Juergen, Jacobsen, Sten Eirik, Fleischmann, Bernd K.

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Generation of Cardiomyocytes from Embryonic Stem Cells: Gewinnung von Kardiomyozyten aus embryonalen Stammzellen. Experimentelle Studien; Experimental Studies by Sachinidis, Agapios, Kolossov, Eugen, Fleischmann, Bernd K, Hescheler, Jürgen

“…Cardiomyopathy is characterized by the loss of functional cardiomyocytes resulting in heart failure. More recently, there is increasing evidence from animal…”
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Generation of Cardiomyocytes from Embryonic Stem Cells by Sachinidis, Agapios, Kolossov, Eugen, Fleischmann, Bernd K., Hescheler, Jürgen

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