Search Results - "KOLOCOURIS, A"

novel analytical method to detect adulteration of virgin olive oil by other oils by Mavromoustakos, T, Zervou, M, Bonas, G, Kolocouris, A, Petrakis, P

“…The present study focuses on the olefinic region of the 13C nuclear magnetic resonance (13C NMR) spectrum of virgin olive oil which shows 12 peaks resonating…”
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Development of simple thiol-reactive liposome formulations, one-step analysis and physicochemical characterization by Kaourma, E., Hatziantoniou, S., Georgopoulos, A., Kolocouris, A., Demetzos, C.

“…The aim of this study was to synthesize simple thiol‐reactive conjugates from maleimide and lipoamines (stearylamine or oleylamine) and to develop a simple,…”
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Novel 3-(2-Adamantyl)pyrrolidines with potent activity against influenza A virus—identification of aminoadamantane derivatives bearing two pharmacophoric amine groups by Stamatiou, George, Kolocouris, Antonios, Kolocouris, Nicolas, Fytas, George, Foscolos, George B, Neyts, Johan, De Clercq, Erik

“…The 3-(2-adamantyl)pyrrolidines 8a– g, 14 were synthesized and evaluated for activity against influenza A virus. The parent N–H compound 14 was several times…”
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Conformation and bioactivity. Design and discovery of novel antihypertensive drugs by Mavromoustakos, T, Zervou, M, Zoumpoulakis, P, Kyrikou, I, Benetis, N P, Polevaya, L, Roumelioti, P, Giatas, N, Zoga, A, Minakakis, P Moutevelis, Kolocouris, A, Vlahakos, D, Grdadolnik, S Golic, Matsoukas, J

“…Peptidomimitism is applied to the medicinal chemistry in order to synthesize drugs that devoid of the disadvantages of peptides. AT1 antagonists constitute a…”
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Ether Phospholipid-AZT Conjugates Possessing Anti-HIV and Antitumor Cell Activity. Synthesis, Conformational Analysis, and Study of Their Thermal Effects on Membrane Bilayers by Mavromoustakos, Thomas, Calogeropoulou, Theodora, Koufaki, Maria, Kolocouris, Antonios, Daliani, Ioanna, Demetzos, Costas, Meng, Zhaoxing, Makriyannis, Alexandros, Balzarini, Jan, Clercq, Erik De

“…The 1-O-hexadecyl-2-O-methyl-sn-glyceryl phosphodiester AZT 4 and hexadecyl-phosphodiester AZT 5 derivatives were synthesized and found to be active against…”
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The effect of neighboring 1- and 2-adamantyl group substitution on the conformations and stereodynamics of N-methylpiperidine. Dynamic NMR spectroscopy and molecular mechanics calculations by Kolocouris, A, Outeiriño, J G, Anderson, J E, Fytas, G, Foscolos, G B, Kolocouris, N

“…When a 1-adamantyl or a 2-adamantyl substituent is introduced at the 2-position in N-methylpiperidine, four different chair conformations are possible…”
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Amantadine copper(II) chloride conjugate with possible implementation in influenza virus inhibition by Banti, C.N., Kourkoumelis, N., Hatzidimitriou, A.G., Antoniadou, Ivi, Dimou, A., Rallis, M., Hoffmann, A., Schmidtke, M., McGuire, K., Busath, D., Kolocouris, A., Hadjikakou, S.K.

“…1-Adamantanamine hydrochloride (AdNH3+ Cl−) is an antiviral drug that is used in the prophylactic or symptomatic treatment of influenza. However, a mutation…”
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Structure elucidation, conformational analysis and thermal effects on membrane bilayers of an antimicrobial myricetin ether derivative by Demetzos, C., Angelopoulou, D., Kolocouris, A., Daliani, I., Mavromoustakos, T.

“…The membrane perturbing 3,7,4′,5′‐tetramethyl ether of myricetin 1 was isolated from Cistus monspelien‐sis L. Its structure was elucidated and its…”
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Free Energy Calculations Reveal the Origin of Binding Preference for Aminoadamantane Blockers of Influenza A/M2TM Pore by Gkeka, Paraskevi, Eleftheratos, Stelios, Kolocouris, Antonios, Cournia, Zoe

“…Aminoadamantane derivatives, such as amantadine and rimantadine, have been reported to block the M2 membrane protein of influenza A virus (A/M2TM), but their…”
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Synthesis and anti-HIV activity of some new aminoadamantane heterocycles by Fytas, G., Stamatiou, G., Foscolos, G.B., Kolocouris, A., Kolocouris, N., Witvrouw, M., Pannecouque, C., De Clercq, E.

“…A new class of aminoadamantane heterocycles has been synthesized and examined for anti-HIV activity. Three compounds proved to be active against the…”
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Spiro[pyrrolidine-2,2′-adamantanes]: synthesis, anti-influenza virus activity and conformational properties by Stylianakis, Ioannis, Kolocouris, Antonios, Kolocouris, Nicolas, Fytas, George, Foscolos, George B, Padalko, Elizaveta, Neyts, Johan, De Clercq, Erik

“…Synthetic spiro[pyrrolidine-2,2′-adamantanes] 2, 3, 11, 15, 12, 16, 18, 20 were evaluated in vitro and found to be active anti-influenza virus A compounds; the…”
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An Effort To Understand the Molecular Basis of Hypertension through the Study of Conformational Analysis of Losartan and Sarmesin Using a Combination of Nuclear Magnetic Resonance Spectroscopy and Theoretical Calculations by Mavromoustakos, Thomas, Kolocouris, Antonios, Zervou, Maria, Roumelioti, Panagiota, Matsoukas, John, Weisemann, Rudiger

“…Losartan is the first recently approved drug against hypertension disease that competes with the biological action of angiotensin II (AII) at the AT1 receptor…”
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Heterocyclic rimantadine analogues with antiviral activity by Stamatiou, George, Foscolos, George B., Fytas, George, Kolocouris, Antonios, Kolocouris, Nicolas, Pannecouque, Christophe, Witvrouw, Myriam, Padalko, Elizaveta, Neyts, Johan, Clercq, Erik De

“…2-(1-Adamantyl)pyrrolidines 6, 7, 2-(1-adamantyl)piperidines 10, 12a– c, 15a, b and 2-(1-adamantyl)hexahydroazepines 19, 21, 22 were synthesized and tested for…”
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Interaction between an Amantadine Analogue and the Transmembrane Portion of the Influenza A M2 Protein in Liposomes Probed by super(1)H NMR Spectroscopy of the Ligand by Kolocouris, A, Hansen, R K, Broadhurst, R W

“…super(1)H NMR spectroscopy of a fluoroamantadine ligand was used to probe the pH dependence of binding to the transmembrane peptide fragment of the influenza A…”
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A simple and rapid method for the differentiation of C-13 manoyl oxide epimers in biologically important samples using GC–MS analysis supported with NMR spectroscopy and computational chemistry results by Demetzos, Costas, Kolocouris, Antonios, Anastasaki, Thalia

“…There is confusion in the literature related to the characterization of biologically important C13 manoyl oxide epimers by using their mass spectrometric data…”
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New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones–thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation by Kolocouris, Antonios, Dimas, Kostas, Pannecouque, Christophe, Witvrouw, Myriam, Foscolos, George B., Stamatiou, George, Fytas, George, Zoidis, Grigoris, Kolocouris, Nicolas, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik

“…The new thiosemicarbazones and thiocarbonohydrazones 4a– d, 5a– d derived from 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane were synthesized and…”
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Synthesis and Antiviral Activity Evaluation of Some New Aminoadamantane Derivatives. 2 by Kolocouris, Nicolas, Kolocouris, Antonios, Foscolos, George B, Fytas, George, Neyts, Johan, Padalko, Elisabeth, Balzarini, Jan, Snoeck, Robert, Andrei, Graciela, De Clercq, Erik

“…The synthesis of some new aminoadamantane derivatives is described. The new compounds were evaluated against a wide range of viruses [influenza A H1N1,…”
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Thermal rearrangement of spiro[naphthalene(naphthopyranofurazan)]oxides to spiro[naphthalene(phenalenofurazan)oxides. A probable furazan oxide triggered tandem isomerisation process by Supsana, Paraskevi, Liaskopoulos, Theodoros, Skoulika, Stavroula, Kolocouris, Antonios, Tsoungas, Petros G., Varvounis, George

“…Thermal rearrangement of (±)-spiro{naphthalene-1(2 H),4′-(naphtho-[2′,1′:2,3]pyrano[4,5- c]furazan)}-2-one-11′-oxides in DMF or acetic anhydride at 140 °C gave…”
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Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles by Setaki, Despina, Tataridis, Dimitris, Stamatiou, George, Kolocouris, Antonios, Foscolos, George B., Fytas, George, Kolocouris, Nicolas, Padalko, Elizaveta, Neyts, Johan, Clercq, Erik De

“…Several compounds between 2-(2-adamantyl)piperidines, 3-(2-adamantyl)pyrrolidines and 2-(2-adamantylmethyl)piperidines were potent against influenza A H 3N 2…”
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Synthesis and Antiviral Activity Evaluation of Some Aminoadamantane Derivatives by Kolocouris, Nicolas, Foscolos, George B, Kolocouris, Antonios, Marakos, Panayotis, Pouli, Nicole, Fytas, George, Ikeda, Satoru, De Clercq, Erik

“…The synthesis of some spiro[cyclopropane-1,2'-adamantan]-2-amines and methanamines and some spiro[pyrrolidine-2,2'-adamantanes] is described. The title…”
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