Search Results - "KOLM, Irene"

Preclinical pharmacokinetics, pharmacodynamics, and efficacy of RG7116: a novel humanized, glycoengineered anti-HER3 antibody by Meneses-Lorente, Georgina, Friess, Thomas, Kolm, Irene, Hölzlwimmer, Gabriele, Bader, Sabine, Meille, Christophe, Thomas, Marlene, Bossenmaier, Birgit

“…Purpose RG7116 is a novel anti-HER3 therapeutic antibody that inhibits HER3 signalling and induces antibody-dependent cellular cytotoxicity of tumor cells due…”
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RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation by MIRSCHBERGER, Christian, SCHILLER, Christian B, HOPFNER, Karl-Peter, NIEDERFELLNER, Gerhard, BOSSENMAIER, Birgit, SCHRÄML, Michael, DIMOUDIS, Nikolaos, FRIESS, Thomas, GERDES, Christian A, REIFF, Ulrike, LIFKE, Valeria, HOELZLWIMMER, Gabriele, KOLM, Irene

“…The EGF receptor (EGFR) HER3 is emerging as an attractive cancer therapeutic target due to its central position in the HER receptor signaling network. HER3…”
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Abstract 2508: GE-huMab-HER3, a novel humanized, glycoengineered HER3 antibody with enhanced ADCC and superior preclinical in vitro and in vivo efficacy by Bossenmaier, Birgit, Friess, Thomas, Gerdes, Christian, Kolm, Irene, Dimoudis, Nikolaos, Lifke, Valeria, Reiff, Ulrike, Moessner, Ekkehard, Hoelzlwimmer, Gabriele, von Hirschheydt, Thomas, Burtscher, Helmut, Niederfellner, Gerhard

“…Abstract HER3 is a member of the Human Epidermal Growth Factor Receptor (HER) family. HER3 is a kinase dead receptor, but by forming heterodimers with other…”
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